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Chemical Structure| 57764-46-2 Chemical Structure| 57764-46-2

Structure of 57764-46-2

Chemical Structure| 57764-46-2

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Product Details of [ 57764-46-2 ]

CAS No. :57764-46-2
Formula : C7H5NO2
M.W : 135.12
SMILES Code : N#CC1=C(O)C=CC=C1O

Safety of [ 57764-46-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 57764-46-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57764-46-2 ]

[ 57764-46-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 16932-49-3 ]
  • [ 57764-46-2 ]
YieldReaction ConditionsOperation in experiment
43.0% With boron tribromide; In [(2)H6]acetone; dichloromethane; Example 1 Synthesis of 2,6-Dihydroxybenzonitrile (2-Cyanoresorcinol) One potential method utilizes boron tribromide to demethylate <strong>[16932-49-3]2,6-dimethoxybenzonitrile</strong> (1 in ) to generate 2,6-dihydroxybenzonitrile (2). Into a 250 mL 3-neck round bottom flask equipped with stir bar, nitrogen inlet, thermometer, and addition funnel was charged <strong>[16932-49-3]2,6-dimethoxybenzonitrile</strong> (3.99 g, 24.5 mmol) and methylene chloride (27 mL). The solution was cooled to -78 C. by submerging the flask in a dry ice/acetone bath. A solution of boron tribromide (25 g, 99.8 mmol) in methylene chloride (27 mL) was added dropwise via the addition funnel over a period of 1 hour. The temperature was maintained at -78 C. for 2 hours. The mixture was allowed to rise to room temperature. The reaction was then stirred at room temperature overnight and refluxed at 55 C. for 10 hours. Excess boron tribromide was decomposed carefully by the addition of moist methylene chloride. Upon removal of the solvent, the crude product was passed through a column of silica gel using 5% acetone in methylene chloride as eluent to afford 1.42 g (43.0%) of a light brown solid, m.p. 197.5-199.6 C. 1H-NMR (DMSO-d6): 6.39-6.41 (d, 2H, Ar-H), 7.20-7.24 (t, 1H), 10.78 (s, 2H, Ar-O-H).
 

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