Select Region or Location
Americas
  • Argentina
  • Brazil
  • Canada
  • Mexico
  • United States
  • Other Americas
Europe
  • Austria
  • Belgium
  • Bulgaria
  • Croatia/Hrvatska
  • Cyprus
  • Czech Republic
  • Denmark
  • Estonia
  • Finland
  • France
  • Germany
  • Greece
  • Hungary
  • Ireland
  • Italy
  • Latvia
  • Liechtenstein
  • Lithuania
  • Luxembourg
  • Malta
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Romania
  • Slovak Republic
  • Slovenia
  • Spain
  • Sweden
  • Switzerland
  • Turkey
  • United Kingdom
  • Other Europe
Asia Pacific
  • Australia
  • China
  • India
  • Indonesia
  • Japan
  • Korea, Republic of
  • Malaysia
  • New Zealand
  • Philippines
  • Singapore
  • Thailand
  • Vietnam
  • Other Asia Pacific
Africa And Middle East
  • Egypt
  • Israel
  • Other Africa And Middle East
USD
Home Cart Sign in  
Chemical Structure| 58455-98-4 Chemical Structure| 58455-98-4

Structure of 58455-98-4

Chemical Structure| 58455-98-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]}{[ size_append_text(item.pr_size, proInfo.prAm, 'list') ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}
    {[ size_append_text(item.pr_size, proInfo.prAm, 'list') ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 58455-98-4 ]

CAS No. :58455-98-4
Formula : C19H29NO5
M.W : 351.44
SMILES Code : O=C(OC(C)(C)C)[C@@H](NC(OCC1=CC=CC=C1)=O)COC(C)(C)C
English Name :Z-Ser(tBu)-OtBu

Safety of [ 58455-98-4 ]

Application In Synthesis of [ 58455-98-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 58455-98-4 ]

[ 58455-98-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 58455-98-4 ]
  • [ 48067-24-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogen In ethanol
With hydrogen
With hydrogen In methanol
With 10% Pd/C; hydrogen In dichloromethane General procedure: A THF solution (15 mL) of Z-Sar-OH (3.10 mmol, see Supplementary Information) is treatedwith NMM(1 equiv), cooled to-15 °C, and then treated with IBCF (1 equiv) under stirring. After 10 min, a cold suspension of H-L-Ser(t-Bu)-O(t-Bu) (4.61 mmol, obtained by previous catalytic hydrogenation in CH2Cl2 of the corresponding Z-protected derivative, see Supplementary Information) in CHCl3 (10 mL) is added and the pH adjusted to ca. 8 with NMM. After being stirred overnight at room temperature, the reaction mixture is concentrated under reduced pressure, the residue taken up with AcOEt, washed with 10% KHSO4, H2O, 5% NaHCO3, H2O, and dried over Na2SO4. The organic layer is then concentrated to dryness and the product purified by flash chromatography using petroleum ether/AcOEt 3:2 as eluent, to obtain Z-Sar-L-Ser(t-Bu)-O(t-Bu). Such intermediate is subsequently Z-deprotected by catalytic hydrogenation inMeOH, and an ether solution ofH-Sar-L-Ser(t-Bu)-O(t-Bu) is dropwise treated with 1 equiv of a dilute ether solution of HCl under stirring. Eventually, the solvent is evaporated to dryness, the residue taken up with fresh ether and filtered, and the solvent removed by evaporation, yielding the corresponding hydrochloride HCl·H-Sar-LSer( t-Bu)-O(t-Bu) as a white powder.

 

Historical Records