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CAS No. : | 59769-22-1 | MDL No. : | MFCD00182122 |
Formula : | C11H11ClN2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 238.67 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With sodium hydride In paraffin oil | 8 4.1.8 Ethyl 2-(2-chloro-1H-benzo[d]imidazol-1-yl)acetate 11 Compound 11 was obtained from commercial 2-chlorobenzimidazole 5 (0.500g, 3.30mmol), sodium hydride suspension (60% suspension in paraffin oil) (0.132g, 3.30mmol) and ethyl bromoacetate (0.38mL, 3.30mmol), according to the procedure described for derivatives 9 and 10. Yield: 97%; m.p.=120-122°C; 1H NMR (DMSO-d6, ppm): 1.23 (t, 3H, J=7.2Hz); 4.20 (q, 2H, J=7.2Hz); 5.27 (s, 2H); 7.26-7.34 (m, 2H); 7.62-7.65 (m, 2H). |
93% | With triethanolamine at 20℃; for 0.1h; Sonication; Green chemistry; | |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; | 29.A To a solution of 2-chloro-lH-benzo [d] imidazole (10 g) and NaH (60% in oil, 3.15 g) in DMF (150 mL) was added ethyl bromoacetate (11.0 mL) at 0 °C. After stirring overnight at room temperature, the reaction mixture was quenched with water and extracted with AcOEt. The extract was washed with water and brine, dried over MgSO^, and concentrated under reduced pressure. The precipitate was crystallized from AcOEt/hexane to give the title compound (12 g) .MS (ESI+) , found: 239.1.XH NMR (300 MHz, CDC13) δ 1.27 (3H, t, J = 7.2 Hz), 4.25 (2H, q, J = 7.2 Hz), 4.90 (2H, s) , 7.17-7.25 (1H, m) , 7.27-7.35 (2H, m) , 7.67-7.75 (1H, m) . |