Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	3348-03-6
Formula :	C₂₅H₁₆O₉
M.W :	460.39
SMILES Code :	O=C(C1=CC(C2(C3=C(OC4=C2C=CC(OC(C)=O)=C4)C=C(OC(C)=O)C=C3)O5)=C(C=C1)C5=O)O
Synonyms :	6-Carboxyfluorescein diacetate
English Name :	6-Carboxyfluorescein diacetate
MDL No. :	MFCD00036871
InChI Key :	QMOGCCYGOPYYNT-UHFFFAOYSA-N
Pubchem ID :	151095

GHS Pictogram:
Signal Word:
Hazard Statements:
Precautionary Statements:
Class:
UN#:
Packing Group:

Yield	Reaction Conditions	Operation in experiment
	Stage #1: recorcinol; trimellitic Anhydride With zinc dibromide at 180℃; for 1.33333h; Stage #2: acetic anhydride for 2h; Reflux; Overall yield = 4.3 g;
1: 161 mg 2: 152 mg	Stage #1: recorcinol; trimellitic Anhydride With methanesulfonic acid at 80℃; for 24h; Stage #2: acetic anhydride With pyridine at 80℃; for 0.0833333h;	5 4. SYNTHESIS OF 5-CARBOXYFLUORESCEIN DIPIVALATE (16) Trimellitic anhydride (436 mg, 1 equiv) and resorcinol (500 mg, 2 equiv) were stirred in methanes ulfonic acid (12 mL) at 80 °C for 24 h. The resulted mixture was poured into ice water (thO). The precipitate was collected and washed with water to yield the crude 5 (6) -carboxy fluorescein (15) (820 mg).5(6)-carboxyfluorescein (15): yellow powder; 'H NMR (500 MHz, methanol -d 8.59 (d, J = 1.5 Hz, 1H), 8.37 (dd, J = 8.0, 1.5 Hz, 1H), 8.31 (dd, J = 8.0, 1.5 Hz, 1H), 8.09 (d, J = 8.0 Hz, lH), 7.74 (s, 1H), 7.30 (d, J = 8.0 Hz, 1H), 6.70-6.72 (d, J = 9.7 Hz, 4H), 6.60- 6.42 (br s, 4H), 6.53-6.57 (m, 4H). 5. SYNTHESIS OF 5-CARBOXYFLUORESCEIN DIACETATE (17)5(6)-carboxyfluorescein (15) (320 mg) and pyridine (260 pL) were stirred in acetic anhydride (5 mL) at 80 °C for 5 min. The solvents were removed in vacuo and the residue was purified by preparative HPLC using a Luna 5 pm C18 column (isocratic, 50% MeCN in 0.1% formic acid) to yield 5-carboxyfluorescein diacetate (17) (161 mg) and 6- carboxy fluorescein diacetate (152 mg).[0487] 5-carboxyfluorescein diacetate (17): yellow powder; 'H NMR (400 MHz, methanol-iL): d 8.61 (s, lH), 8.37 (d, J = 8.0 Hz, lH), 7.32 (d, J = 8.0 Hz, lH), 7.18 (br s, 2H), 6.88 (br s, 4H), 2.28 (s, 6H).

Precautionary Statements-General
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P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
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P233	Keep container tightly closed.
P234	Keep only in original container.
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P285	In case of inadequate ventilation wear respiratory protection.
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P321
P322
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P378
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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P401
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Disposal
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P501	Dispose of contents/container to ...
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CAS No.: 3348-03-6

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CAS No.: 3348-03-6

Alternative Products

Product Details of 6-CFDA

Safety of 6-CFDA

Application In Synthesis of 6-CFDA

[ 3348-03-6 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed