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[ CAS No. 60032-95-3 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 60032-95-3

Chemical Structure| 60032-95-3

Chemical Structure| 60032-95-3

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Quality Control of [ 60032-95-3 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 60032-95-3 ]

CAS No. :	60032-95-3	MDL No. :	MFCD00079727
Formula :	C₉H₉ClO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CHMWIAHMSOASPM-UHFFFAOYSA-N
M.W :	216.62	Pubchem ID :	2757463
Synonyms :

Safety of [ 60032-95-3 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:
Hazard Statements:	H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 60032-95-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 60032-95-3 ]

[ 60032-95-3 ] Synthesis Path-Downstream 1~42

1
[ 60032-95-3 ]
[ 87932-51-2 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen bromide; acetic acid

Reference： [1]Tomita et al. [Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 1122,1125][Chem.Abstr., 1957, p. 3505]

2
[ 18093-05-5 ]
[ 60032-95-3 ]

Reference： [1]Journal of Organic Chemistry,1943,vol. 8,p. 358,363,365

Yield	Reaction Conditions	Operation in experiment
	4, anod. Oxid.;

4
[ 60032-95-3 ]
[ 237384-60-0 ]

Yield	Reaction Conditions	Operation in experiment
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
	With oxalyl dichloride In dichloromethane at 20℃;
	With thionyl chloride at 90℃; for 3h;

With oxalyl dichloride In dichloromethane at 20℃; for 2h;

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]
[2]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]
[3]Location in patent: experimental part Bland, Nicholas D.; Wang, Cuihua; Tallman, Craig; Gustafson, Alden E.; Wang, Zhouxi; Ashton, Trent D.; Ochiana, Stefan O.; McAllister, Gregory; Cotter, Kristina; Fang, Anna P.; Gechijian, Lara; Garceau, Norman; Gangurde, Rajiv; Ortenberg, Ron; Ondrechen, Mary Jo; Campbell, Robert K.; Pollastri, Michael P. [Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 8188 - 8194]
[4]Schrader, Florian C.; Glinca, Serghei; Sattler, Julia M.; Dahse, Hans-Martin; Afanador, Gustavo A.; Prigge, Sean T.; Lanzer, Michael; Mueller, Ann-Kristin; Klebe, Gerhard; Schlitzer, Martin [ChemMedChem, 2013, vol. 8, # 3, p. 442 - 461]

5
[ 60032-95-3 ]
[ 108-39-4 ]
[ 949580-84-1 ]

Yield	Reaction Conditions	Operation in experiment
37%	With pyridine; copper(l) iodide; potassium carbonate In water for 2h; Heating;

Reference： [1]Piazzi, Lorna; Cavalli, Andrea; Belluti, Federica; Bisi, Alessandra; Gobbi, Silvia; Rizzo, Stefano; Bartolini, Manuela; Andrisano, Vincenza; Recanatini, Maurizio; Rampa, Angela [Journal of Medicinal Chemistry, 2007, vol. 50, # 17, p. 4250 - 4254]

6
[ 108-43-0 ]
[ 60032-95-3 ]
2-(3-chlorophenoxy)-4,5-dimethoxybenzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
41%	With copper(l) iodide; copper; potassium carbonate In nitrobenzene at 170 - 180℃; for 8h;

Reference： [1]Piazzi, Lorna; Belluti, Federica; Bisi, Alessandra; Gobbi, Silvia; Rizzo, Stefano; Bartolini, Manuela; Andrisano, Vincenza; Recanatini, Maurizio; Rampa, Angela [Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 1, p. 575 - 585]

7
[ 60032-95-3 ]
[ 949580-65-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 37 percent / K₂CO₃; CuI; pyridine / Cu / H₂O / 2 h / Heating 2: 14 percent / aq. H₃PO₄; P₂O₅ / 4 h / 110 °C

Reference： [1]Piazzi, Lorna; Cavalli, Andrea; Belluti, Federica; Bisi, Alessandra; Gobbi, Silvia; Rizzo, Stefano; Bartolini, Manuela; Andrisano, Vincenza; Recanatini, Maurizio; Rampa, Angela [Journal of Medicinal Chemistry, 2007, vol. 50, # 17, p. 4250 - 4254]

8
[ 60032-95-3 ]
[ 949580-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 37 percent / K₂CO₃; CuI; pyridine / Cu / H₂O / 2 h / Heating 2: 14 percent / aq. H₃PO₄; P₂O₅ / 4 h / 110 °C 3: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 6 h / Heating

Reference： [1]Piazzi, Lorna; Cavalli, Andrea; Belluti, Federica; Bisi, Alessandra; Gobbi, Silvia; Rizzo, Stefano; Bartolini, Manuela; Andrisano, Vincenza; Recanatini, Maurizio; Rampa, Angela [Journal of Medicinal Chemistry, 2007, vol. 50, # 17, p. 4250 - 4254]

9
[ 60032-95-3 ]
C₂₄H₂₃NO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 37 percent / K₂CO₃; CuI; pyridine / Cu / H₂O / 2 h / Heating 2: 14 percent / aq. H₃PO₄; P₂O₅ / 4 h / 110 °C 3: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 6 h / Heating 4: 40 mg / toluene / 15 h / Heating

Reference： [1]Piazzi, Lorna; Cavalli, Andrea; Belluti, Federica; Bisi, Alessandra; Gobbi, Silvia; Rizzo, Stefano; Bartolini, Manuela; Andrisano, Vincenza; Recanatini, Maurizio; Rampa, Angela [Journal of Medicinal Chemistry, 2007, vol. 50, # 17, p. 4250 - 4254]

10
[ 60032-95-3 ]
2-chloro-4,5-dimethoxy-benzoyl isothiocyanate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

11
[ 60032-95-3 ]
3-(2-chloro-4,5-dimethoxy-benzoyl)-1-(1-phenyl-butyl)-1-propyl-thiourea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating 3: Na₂CO₃ / CH₂Cl₂; tetrahydrofuran; acetone / Heating

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

12
[ 60032-95-3 ]
3-(2-Chloro-4,5-dimethoxy-benzoyl)-1-((S)-1-phenyl-butyl)-1-propyl-thiourea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating 3: tetrahydrofuran / 20 °C

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

13
[ 60032-95-3 ]
[5-(2-chloro-4,5-dimethoxy-phenyl)-1-methyl-1<i>H</i>-[1,2,4]triazol-3-yl]-(1-phenyl-butyl)-propyl-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating 3: Na₂CO₃ / CH₂Cl₂; tetrahydrofuran; acetone / Heating 4: tetrahydrofuran; CH₂Cl₂; acetone / Heating 5: 3.9 mg / 100 °C

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

14
[ 60032-95-3 ]
(S)-1-methyl-3-[N-(1-phenylbutyl)-N-propylamino]-5-(2-chloro-4,5-dimethoxyphenyl)-1H-[1,2,4]triazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating 3: tetrahydrofuran / 20 °C 4: Na₂CO₃ / tetrahydrofuran / 70 °C 5: 100 °C

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

15
[ 60032-95-3 ]
3-(2-chloro-4,5-dimethoxy-benzoyl)-2-methyl-1-(1-phenyl-butyl)-1-propyl-isothiourea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating 3: Na₂CO₃ / CH₂Cl₂; tetrahydrofuran; acetone / Heating 4: tetrahydrofuran; CH₂Cl₂; acetone / Heating

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

16
[ 60032-95-3 ]
3-(2-Chloro-4,5-dimethoxy-benzoyl)-2-methyl-1-((S)-1-phenyl-butyl)-1-propyl-isothiourea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: (COCl)2 / CH₂Cl₂ / 20 °C 2: tetrahydrofuran; acetone / Heating 3: tetrahydrofuran / 20 °C 4: Na₂CO₃ / tetrahydrofuran / 70 °C

Reference： [1]Lowe, Richard F.; Nelson, Jodene; Dang, Trunghau N.; Crowe, Paul D.; Pahuja, Anil; McCarthy, James R.; Grigoriadis, Dimitri E.; Conlon, Paul; Saunders, John; Chen, Chen; Szabo, Thomas; Chen, Ta Kung; Bozigian, Haig [Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1540 - 1549]

17
[ 60032-95-3 ]
2-chloro-4,5-dimethoxy-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

18
[ 60032-95-3 ]
2-chloro-4,5-dimethoxy-<i>N</i>-thioacetyl-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

19
[ 60032-95-3 ]
2-chloro-4,5-dimethoxy-<i>N</i>-(1-methylsulfanyl-ethylidene)-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

20
[ 60032-95-3 ]
2-chloro-<i>N</i>-(1-dimethylamino-ethylidene)-4,5-dimethoxy-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

21
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-7-ethyl-2-methyl-8-(1-methyl-butyl)-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: 4-(dimethylamino)pyridine / dioxane / 15 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

22
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-8-cyclobutyl-7-ethyl-2-methyl-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C 6: dioxane / 2 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

23
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-7-ethyl-8-(1-ethyl-propyl)-2-methyl-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C 6: dioxane / 2 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

24
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-7-ethyl-8-(1-methoxymethyl-butyl)-2-methyl-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: 4-(dimethylamino)pyridine / dioxane / 15 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

25
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-8-cyclopentyl-7-ethyl-2-methyl-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C 6: dioxane / 2 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

26
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-7-ethyl-2-methyl-8-(tetrahydro-pyran-4-yl)-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C 6: dioxane / 2 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

27
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-7-ethyl-2-methyl-8-(1-propyl-butyl)-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: 4-(dimethylamino)pyridine / dioxane / 15 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

28
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-8-(1-cyclobutyl-3-methoxy-propyl)-7-ethyl-2-methyl-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C 6: dioxane / 2 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

29
[ 60032-95-3 ]
4-(2-chloro-4,5-dimethoxy-phenyl)-7-ethyl-8-[3-methoxy-1-(tetrahydro-furan-3-yl)-propyl]-2-methyl-pyrazolo[1,5-<i>a</i>][1,3,5]triazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: (COCl)2; DMF / CH₂Cl₂ 2: ammonium hydroxide / dioxane 3: Heating 4: hydrogen sulfide; acetic acid 5: K₂CO₃ / acetonitrile / 2.5 h / 20 °C 6: dioxane / 2 h / Heating

Reference： [1]Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 18, p. 4093 - 4102]

30
[ 120-14-9 ]
[ 60032-95-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: chloroform; chlorine / 40 - 50 °C 2: pyridine; aqueous potassium permanganate solution

Reference： [1]Raiford; Floyd [Journal of Organic Chemistry, 1943, vol. 8, p. 358,363,365]

31
PCl [ No CAS ]
[ 60032-95-3 ]
[ 237384-60-0 ]
[ 237384-61-1 ]

Yield	Reaction Conditions	Operation in experiment
0.52 g (96%)		45.a 4-[4(2-Chloro-4,5-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine a) Methyl 4-[4-(2-chloro-4,5-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate 2-Chloro-4,5-dimethoxybenzoic acid (0.5 g, 2.3 mmol) and PCl (0.54 g, 2.6 mmol) were placed in a round bottomed flask fitted with a reflux condenser. The mixture was heated in an oil bath at 120° C. for 70 min. The mixture was allowed to cool and the formed phosphorus oxychloride was removed under vacuum to give 0.52 g (96%) of 2-chloro-4,5-dimethoxybenzoyl chloride as a solid. 2-Chloro-4,5-dimethoxybenzoyl chloride (0.52 g, 2.2 mmol) was treated in a manner similar to that for Example 32 step (a) to give 2-bromo-1-(2-chloro-4,5-dimethoxyphenyl) ethan-1-one. The dry solid (0.65 g, 2.2 mmol) was dissolved in acetone (25 ml).

Reference： [1]Current Patent Assignee: JOHNSON & JOHNSON INC - US2002/37915, 2002, A1

32
[ 60032-95-3 ]
[ 237384-60-0 ]
[ 237384-61-1 ]

Yield	Reaction Conditions	Operation in experiment
0.52 g (96%)	With phosphorus pentachloride	45.a 4-[4-(2-Chloro-4,5-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine a) Methyl 4-[4-(2-chloro-4,5-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate 2-Chloro-4,5-dimethoxybenzoic acid (0.5 g, 2.3 mmol) and PCl5 (0.54 g, 2.6 mmol) were placed in a round bottomed flask fitted with a reflux condenser. The mixture was heated in an oil bath at 120° C. for 70 min. The mixture was allowed to cool and the formed phosphorus oxychloride was removed under vacuum to give 0.52 g (96%) of 2-chloro-4,5-dimethoxybenzoyl chloride as a solid. 2-Chloro-4,5-dimethoxybenzoyl chloride (0.52 g, 2.2 mmol) was treated in a manner similar to that for Example 32 step (a) to give 2-bromo-1-(2-chloro-4,5-dimethoxyphenyl)ethan-1-one. The dry solid (0.65 g, 2.2 mmol) was dissolved in acetone (25 ml).

Reference： [1]Current Patent Assignee: JOHNSON & JOHNSON INC - US6291514, 2001, B1

33
[ 60032-95-3 ]
[ 115279-57-7 ]
[ 1067191-52-9 ]

Yield	Reaction Conditions	Operation in experiment
17%		A mixture of <strong>[115279-57-7]2-(4-amino-phenyl)-2-methyl-propionitrile</strong> (160 mg; 0.50 mmol), prepared as in l(B), 2-chloro-4,5-dimethoxy-benzoic acid (108 mg, 0.50 mmol), HOBt (77.0 mg; 0.50 mmol), EDC (144 mg; 0.75 mmol) and TEA (140 uL; 1.00 mmol) in dioxane (6 mL) was warmed at 100C for 2 hours. Then, the reaction was diluted with DCM and washed with IN HCl and 5% NaHCO3. The organic phase was collected, dried (Na2SO4), filtered and evaporated to dryness. The crude product was purified by chromatography [SiO2, Petroleum ether/EtOAc (1/1)] to give the title compound as a white solid (30.0 mg; 17% yield).IH NMR (300 MHz, CDC13-d) delta(ppm): 8.33 (br. s., 1 H), 7.70 (m, 2 H), 7.50 (m, 2 H), 7.48 (s, 1 H), 6.91 (s, 1 H), 3.94-3.97 (m, 3 H), 3.95 (d, 3 H), 1.76 (s, 6 H).LCMS (RT): 2.24 min (Method G); MS (ES+) gave m/z: 359.18 (MH+). MP: 142-144 C.

Reference： [1]Patent: WO2008/117175,2008,A2 .Location in patent: Page/Page column 157

34
[ 60032-95-3 ]
[ 1463965-25-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 2 h / 20 °C 2: triethylamine / tetrahydrofuran / 2 h / 20 °C

Reference： [1]Schrader, Florian C.; Glinca, Serghei; Sattler, Julia M.; Dahse, Hans-Martin; Afanador, Gustavo A.; Prigge, Sean T.; Lanzer, Michael; Mueller, Ann-Kristin; Klebe, Gerhard; Schlitzer, Martin [ChemMedChem, 2013, vol. 8, # 3, p. 442 - 461]

35
[ 1131-62-0 ]
[ 60032-95-3 ]
[ 93-07-2 ]

Yield	Reaction Conditions	Operation in experiment
1: 61.4% 2: 20.3%	With sodium hypochlorite; sodium hydroxide In water at 40℃; for 1h;

Reference： [1]Bjorsvik, Hans-Rene; Norman, Kristine [Organic Process Research and Development, 1999, vol. 3, # 5, p. 341 - 346]

36
[ 60032-95-3 ]
N<SUP>5</SUP>-(4-aminophenyl)-N<SUP>4</SUP>-methyl-1H-imidazole-4,5-dicarboxamide [ No CAS ]
N₅-{4-[(2-chloro-4,5-dimethoxybenzoyl)amino]phenyl}-N₄-methyl-1H-imidazole4,5-dicarboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45.5 mg	With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	240 N5-f4-[ (2-ch loro-4, 5-dimethoxybenzoyl)amino]phenyl}-N4-methyl- I H-imidazole4, 5-dicarboxamide 0.34 mL (0.58 mmo[, 1.5 equiv., 50% so[ution in DMF) 1-propanephosphonic anhydride (T3P) was added to a mixture of 100 mg (0.386 mmo[, 1.0 equiv.) N5-(4-aminopheny[)-N4-methy[-1H-imidazo[e-4, 5-dicarboxamide (Intermediate 003), 109mg (0.501 mmo[, 1.3 equiv.) 2-ch[oro-4,5-dimethoxybenzoic acid (CAS No. 60032- 95-3) and 0.35 mL (1.9 mmo[, 5.0 equiv.) N,N-diisopropy[ethy[amine in 2.5 mL DMF and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated and the residue was purified by preparative HPLC to give thetit[e compound (45.5 mg).1H-NMR (400 MHz, DMSO-d6): 6 [ppm] = 13.67 (br. s., 1H), 13.31-12.08 (m, 1H),10.36 (s, 1H), 8.84 (br. s., 1H), 7.93 (s, 1H), 7.83-7.60 (m, 4H), 7.18 (s, 1H), 7.12(s, 1H), 3.84 (s, 3H), 3.82 (s, 3H), 2.88 (d, 3H).LC-MS (Method 8): R = 0.87 mm; MS (ESipos) m/z = 458.2 [M+H]÷.

Reference： [1]Current Patent Assignee: BAYER AG - WO2015/150449, 2015, A2 Location in patent: Page/Page column 402; 403

37
[ 60032-95-3 ]
4,5,2'-tris(N,N-dimethylformoyloxy)-2,5'-dichlorobenzophenone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 6 h / 78 °C 1.2: 4 h / 20 °C 2.1: boron tribromide / dichloromethane / 2 h / 20 °C 3.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C

Reference： [1]Current Patent Assignee: SHANXI MEDICAL UNIVERSITY - CN105884657, 2016, A

38
[ 60032-95-3 ]
4,5,2'-trihydroxy-2,5'-dichlorobenzophenone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 6 h / 78 °C 1.2: 4 h / 20 °C 2.1: boron tribromide / dichloromethane / 2 h / 20 °C

Reference： [1]Current Patent Assignee: SHANXI MEDICAL UNIVERSITY - CN105884657, 2016, A

39
[ 623-12-1 ]
[ 60032-95-3 ]
4,5,2'-trimethoxy-2,5'-dichlorobenzophenone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.22 g	Stage #1: 2-chloro-4,5-dimethoxybenzoic acid With thionyl chloride In N,N-dimethyl-formamide at 78℃; for 6h; Stage #2: 4-chloromethoxybenzene With aluminum (III) chloride In dichloromethane at 20℃; for 4h;	1 1.20 g (5.55 mmol) of 2-chloro-4,5-dimethoxybenzoic acid were dissolved in 1.5 mL of anhydrous thionyl chloride,A solution of N, N-dimethylformamide (DMF)And refluxed at 78 ° C for 6 h.After removal of the solvent under reduced pressure,The residual thionyl chloride was removed in two portions with 4 mL of anhydrous methylene chloride,To give a white solid,Was dissolved in 5 mL of anhydrous dichloromethane,Ice bath in batches0.77 g (5.80 mmol) of anhydrous aluminum chloride and 0.85 g (6.0 mmol) of 4-chloroanisole,The reaction was stirred at room temperature for 4 h.Add appropriate amount of ice water to terminate the reaction,The aqueous phase was extracted twice with 10 mL of dichloromethane,The organic phases were combined, washed with saturated brine to neutral, and dried over anhydrous sodium sulfate. Column chromatography was carried out with petroleum ether / ethyl acetate (8/2) as eluant. The solvent was removed under reduced pressure and dried to give 0.22 g of a white solid.

Reference： [1]Current Patent Assignee: SHANXI MEDICAL UNIVERSITY - CN105884657, 2016, A Location in patent: Paragraph 0046; 0047; 0048

40
[ 60032-95-3 ]
[ 189999-35-7 ]
[ 17825-74-0 ]

Yield	Reaction Conditions	Operation in experiment
57%	With palladium diacetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 17h;

Reference： [1]Yang, Shuai; Wang, Feng; Wu, Yanqi; Hua, Wenkai; Zhang, Fengzhi [Organic Letters, 2018, vol. 20, # 6, p. 1491 - 1495]

41
[ 60032-95-3 ]
[ 1600505-68-7 ]
6-(tert-butyl)-2,3-dimethoxytriphenylene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With palladium diacetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 17h;

Reference： [1]Yang, Shuai; Wang, Feng; Wu, Yanqi; Hua, Wenkai; Zhang, Fengzhi [Organic Letters, 2018, vol. 20, # 6, p. 1491 - 1495]

42
[ 60032-95-3 ]
C₂₅H₃₉N₃O₁₀P^(1-)*Na⁽¹⁺⁾ [ No CAS ]
C₃₄H₄₆ClN₃O₁₃P^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃;

Reference： [1]Yuhas, Shelby C.; Laverty, Daniel J.; Lee, Huijin; Majumdar, Ananya; Greenberg, Marc M. [Journal of the American Chemical Society, 2021, vol. 143, # 21, p. 8099 - 8107]

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Isomers

Technical Information

• Acetal Formation • Acid-Catalyzed α -Halogenation of Ketones • Acidity of Phenols • Acids Combine with Acyl Halides to Produce Anhydrides • Acyl Chloride Hydrolysis • Addition of a Hydrogen Halide to an Internal Alkyne • Alcohols from Haloalkanes by Acetate Substitution-Hydrolysis • Alcohols React with PX3 • Alkyl Halide Occurrence • Alkylation of an Alkynyl Anion • Amide Hydrolysis • Amide Hydrolysis • An Alkane are Prepared from an Haloalkane • Anhydride Hydrolysis • Arndt-Eistert Homologation • Benzylic Oxidation • Birch Reduction • Birch Reduction of Benzene • Blanc Chloromethylation • Carbonation of Organometallics • Carboxylate Salt Formation • Carboxylic Acids React with Alcohols to Form Esters • Chan-Lam Coupling Reaction • Chloroalkane Synthesis with SOCI2 • Complete Benzylic Oxidations of Alkyl Chains • Complete Benzylic Oxidations of Alkyl Chains • Conjugate Additions of p-Benzoquinones • Conversion of Amino with Nitro • Convert Haloalkanes into Alcohols by SN2 • Decarboxylation of Substituted Propanedioic • Decomposition of Arenediazonium Salts to Give Phenols • Deprotection of Cbz-Amino Acids • Deprotonation of Methylbenzene • Diazo Coupling • Directing Electron-Donating Effects of Alkyl • Electrophilic Chloromethylation of Polystyrene • Electrophilic Substitution of the Phenol Aromatic Ring • Esters Are Reduced by LiAlH4 to Give Alcohols • Esters Hydrolyze to Carboxylic Acids and Alcohols • Ether Synthesis by Oxymercuration-Demercuration • Etherification Reaction of Phenolic Hydroxyl Group • Ethers Synthesis from Alcohols with Strong Acids • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Friedel-Crafts Alkylation of Benzene with Acyl Chlorides • Friedel-Crafts Alkylation of Benzene with Carboxylic Anhydrides • Friedel-Crafts Alkylation of Benzene with Haloalkanes • Friedel-Crafts Alkylation Using Alkenes • Friedel-Crafts Alkylations of Benzene Using Alkenes • Friedel-Crafts Alkylations Using Alcohols • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Grignard Reagents Transform Esters into Alcohols • Groups that Withdraw Electrons Inductively Are Deactivating and Meta Directing • Halogenation of Alkenes • Halogenation of Benzene • Halogenation of Phenols • Hiyama Cross-Coupling Reaction • Hunsdiecker-Borodin Reaction • Hydrogenation to Cyclohexane • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kolbe-Schmitt Reaction • Kumada Cross-Coupling Reaction • Methylation of Ammonia • Nitration of Benzene • Nitriles Hydrolyze to Carboxylic Acids • Nomenclature of Ethers • Nucleophilic Aromatic Substitution • Nucleophilic Aromatic Substitution with Amine • Oxidation of Aldehydes Furnishes Carboxylic Acids • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Oxidation of Phenols • Oxidation of Primary Alcohols Furnishes Carboxylic Acids • Passerini Reaction • Pechmann Coumarin Synthesis • Peptide Bond Formation with DCC • Periodic Acid Degradation of Sugars • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Carboxylic Acids • Preparation of Ethers • Primary Ether Cleavage with Strong Nucleophilic Acids • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reactions of Dihalides • Reactions of Ethers • Reduction of Carboxylic Acids by LiAlH4 • Reduction of Carboxylic Acids by Lithium Aluminum Hydride • Reduction of Carboxylic Acids by Lithium Aluminum Hydride • Reductive Removal of a Diazonium Group • Reimer-Tiemann Reaction • Reverse Sulfonation——Hydrolysis • Ring Opening of Oxacyclopropane • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Sulfonation of Benzene • Suzuki Coupling • Synthesis of Alcohols from Tertiary Ethers • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Conversion of Carboxylic Acids into Acyl Halides • The Nitro Group Conver to the Amino Function • The Nucleophilic Opening of Oxacyclopropanes • Ugi Reaction • Vilsmeier-Haack Reaction

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[ 60032-95-3 ]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
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P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
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Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
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P310	Immediately call a POISON CENTER or doctor/physician.
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P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
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P363	Wash contaminated clothing before reuse.
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P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
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P411
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P411 + P235	Keep cool.
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P501	Dispose of contents/container to ...
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Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
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H220	Extremely flammable gas
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
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Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
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H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
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H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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