[ CAS No. 60093-05-2 ]

Name: 60093-05-2|Methyl 4-amino-2-(methylthio)thiazole-5-carboxylate|98%
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Product Details of [ 60093-05-2 ]

CAS No. :	60093-05-2	MDL No. :	MFCD00799293
Formula :	C₆H₈N₂O₂S₂	Boiling Point :	359.5°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	204.27 g/mol	Pubchem ID :	-
Synonyms :

Calculated chemistry of of [ 60093-05-2 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	5
Fraction Csp3 :	0.33
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	49.52
TPSA :	118.75 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.99 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.88
Log Po/w (XLOGP3) :	2.19
Log Po/w (WLOGP) :	1.24
Log Po/w (MLOGP) :	0.11
Log Po/w (SILICOS-IT) :	1.78
Consensus Log Po/w :	1.44

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.6
Solubility :	0.517 mg/ml ; 0.00253 mol/l
Class :	Soluble
Log S (Ali) :	-4.32
Solubility :	0.00983 mg/ml ; 0.0000481 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-1.52
Solubility :	6.23 mg/ml ; 0.0305 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.56

Safety of [ 60093-05-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 60093-05-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 60093-05-2 ]
Downstream synthetic route of [ 60093-05-2 ]

[ 60093-05-2 ] Synthesis Path-Upstream 1~2

1
[ 60093-05-2 ]
[ 278183-10-1 ]

Yield	Reaction Conditions	Operation in experiment
24%	With hydrogen In ethanol; water for 168 h;	A suspension of methyl 4-amino-2-methylthio-1, 3-thiazole-5-carboxylate (6.74 g, 33 mmol) and Raney-Nickel (commercially available slurry in water, ca. 15 ml, added in 5 portions throughout the reaction) in ethanol (200 ml) was hydrogenated at 45 psi for 1 week. The catalyst was removed by filtration, washed with ethyl acetate and ethanol and the filtrate evaporated. The resulting solid was purified by flash column chromatography [eluant: ethyl acetate/ isohexane (1: 4) ] to give the title compound as a bright yellow solid (1.23 g,24 percent).oh NMR (400 MHz,CDCl3)8 8.54(1H, s), 5.90 (2H, brs), 3.84 (3H, s). M/z (ES+) 159 (M+H+).

Reference： [1] Patent: WO2005/49613, 2005, A1, . Location in patent: Page/Page column 42

2
[ 60093-05-2 ]
[ 74-93-1 ]
[ 278183-10-1 ]

Yield	Reaction Conditions	Operation in experiment
34%	With hydrogenchloride; zinc In methanol; water for 1.5 h;	This material was prepared using the general procedure of Baldwin, John J.; Engelhardt, Edward L.; Hirschmann, Ralph; Ponticello, Gerald S.; Atkinson, Joseph G.; Wasson, Burton K.; Sweet, Charles S.; Scriabine, Alexander. Heterocyclic analogs of the antihypertensive β-adrenergic blocking agent (S)-2-[3-(fe/t-butylamino)-2- hydroxypropoxy]-3-cyanopyridine. Journal of Medicinal Chemistry (1980), 23(1), 65-70, which is hereby incorporated by reference, as follows: A mixture of methyl 4-amino-2- (methylthio)-l,3-thiazole-5-carboxylate (2.55 g, 12.5 mmol) in methanol (50 mL) was stirred with warming until all material was dissolved and then allowed to cool to ambient temperature before zinc dust (4.90 g, 75 mmol) was added. A 3 N hydrochloric acid solution in methanol was prepared by cautiously adding the appropriate quantity of concentrated aqueous HCl to methanol. The reaction flask with a rapidly stirred suspension of zinc and starting material in methanol was continuously flushed with nitrogen as 2.5 mL portions of the HCl solution were added at 10-minute intervals. During this addition, rapid evolution of gas ensued which was passed from the reaction flask into a bubbler of bleach to capture evolved methanethiol. Periodic HPLC analysis EPO <DP n="32"/>indicated that 1.5 h after the last of ten portions of HCl was added, most of the starting material was gone. The reaction mixture was slowly poured into a rapidly stirred suspension of Celite.(R). in 200 mL saturated aqueous sodium carbonate. The resulting mixture was filtered and the solids were rinsed with minimal methanol. Water (100 mL) was added to the filtrate that was then extracted three times with dichloromethane. Combined extracts were washed with saturated brine, dried (Na₂SO₄) and evaporated in vacuo to yield technical grade title compound (684 mg, 34percent) which appeared reasonably pure by NMR and HPLC analysis and was used directly in the next reaction.¹H NMR (300 MHz, DMSO-J₆) δ 8.93 (s, IH), 7.00 (bs, 2H) and 3.72 ppm (s, 3H); HPLC RT (min) 1.43.

Reference： [1] Patent: WO2006/96338, 2006, A1, . Location in patent: Page/Page column 30-31

[ 60093-05-2 ] Synthesis Path-Downstream 1~14

1
[ 10191-61-4 ]
[ 96-34-4 ]
[ 60093-05-2 ]

Yield	Reaction Conditions	Operation in experiment
	In acetone

Reference： [1]Walek,W. et al. [Tetrahedron, 1976, vol. 32, p. 623 - 627]

2
[ 905434-97-1 ]
[ 60093-05-2 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In N,N-dimethyl-formamide

Reference： [1]Johnson, Sigmond G.; Connolly, Peter J.; Murray, William V. [Tetrahedron Letters, 2006, vol. 47, # 28, p. 4853 - 4856]

3
[ 4637-24-5 ]
[ 60093-05-2 ]
4-(dimethylamino-methyleneamino)-2-methylsulfanyl-thiazole-5-carboxylic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	In N,N-dimethyl-formamide

Reference： [1]Johnson, Sigmond G.; Connolly, Peter J.; Murray, William V. [Tetrahedron Letters, 2006, vol. 47, # 28, p. 4853 - 4856]

4
[ 10191-61-4 ]
[ 96-34-4 ]
[ 60093-05-2 ]

Yield	Reaction Conditions	Operation in experiment
68%	With triethylamine In acetone

Reference： [1]Johnson, Sigmond G.; Connolly, Peter J.; Murray, William V. [Tetrahedron Letters, 2006, vol. 47, # 28, p. 4853 - 4856]

5
4-(dimethylamino-methyleneamino)-2-methylsulfanyl-thiazole-5-carboxylic acid methyl ester [ No CAS ]
[ 60093-05-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: LiHMDS / acetonitrile; tetrahydrofuran 2: Et₃N / dimethylformamide

Reference： [1]Johnson, Sigmond G.; Connolly, Peter J.; Murray, William V. [Tetrahedron Letters, 2006, vol. 47, # 28, p. 4853 - 4856]

6
[ 60093-05-2 ]
[ 278183-10-1 ]

Yield	Reaction Conditions	Operation in experiment
24%	With hydrogen;nickel; In ethanol; water; under 2327.23 Torr; for 168h;	A suspension of methyl 4-amino-2-methylthio-1, 3-thiazole-5-carboxylate (6.74 g, 33 mmol) and Raney-Nickel (commercially available slurry in water, ca. 15 ml, added in 5 portions throughout the reaction) in ethanol (200 ml) was hydrogenated at 45 psi for 1 week. The catalyst was removed by filtration, washed with ethyl acetate and ethanol and the filtrate evaporated. The resulting solid was purified by flash column chromatography [eluant: ethyl acetate/ isohexane (1: 4) ] to give the title compound as a bright yellow solid (1.23 g,24 %).oh NMR (400 MHz,CDCl3)8 8.54(1H, s), 5.90 (2H, brs), 3.84 (3H, s). M/z (ES+) 159 (M+H+).

Reference： [1]Patent: WO2005/49613,2005,A1 .Location in patent: Page/Page column 42

7
[ 60093-05-2 ]
[ 74-93-1 ]
[ 278183-10-1 ]

Yield	Reaction Conditions	Operation in experiment
34%	With hydrogenchloride; zinc; In methanol; water; for 1.5h;	This material was prepared using the general procedure of Baldwin, John J.; Engelhardt, Edward L.; Hirschmann, Ralph; Ponticello, Gerald S.; Atkinson, Joseph G.; Wasson, Burton K.; Sweet, Charles S.; Scriabine, Alexander. Heterocyclic analogs of the antihypertensive beta-adrenergic blocking agent (S)-2-[3-(fe/t-butylamino)-2- hydroxypropoxy]-3-cyanopyridine. Journal of Medicinal Chemistry (1980), 23(1), 65-70, which is hereby incorporated by reference, as follows: A mixture of methyl 4-amino-2- (methylthio)-l,3-thiazole-5-carboxylate (2.55 g, 12.5 mmol) in methanol (50 mL) was stirred with warming until all material was dissolved and then allowed to cool to ambient temperature before zinc dust (4.90 g, 75 mmol) was added. A 3 N hydrochloric acid solution in methanol was prepared by cautiously adding the appropriate quantity of concentrated aqueous HCl to methanol. The reaction flask with a rapidly stirred suspension of zinc and starting material in methanol was continuously flushed with nitrogen as 2.5 mL portions of the HCl solution were added at 10-minute intervals. During this addition, rapid evolution of gas ensued which was passed from the reaction flask into a bubbler of bleach to capture evolved methanethiol. Periodic HPLC analysis EPO <DP n="32"/>indicated that 1.5 h after the last of ten portions of HCl was added, most of the starting material was gone. The reaction mixture was slowly poured into a rapidly stirred suspension of Celite in 200 mL saturated aqueous sodium carbonate. The resulting mixture was filtered and the solids were rinsed with minimal methanol. Water (100 mL) was added to the filtrate that was then extracted three times with dichloromethane. Combined extracts were washed with saturated brine, dried (Na2SO4) and evaporated in vacuo to yield technical grade title compound (684 mg, 34%) which appeared reasonably pure by NMR and HPLC analysis and was used directly in the next reaction.1H NMR (300 MHz, DMSO-J6) delta 8.93 (s, IH), 7.00 (bs, 2H) and 3.72 ppm (s, 3H); HPLC RT (min) 1.43.

Reference： [1]Patent: WO2006/96338,2006,A1 .Location in patent: Page/Page column 30-31

8
[ 407-25-0 ]
[ 60093-05-2 ]
[ 1078789-22-6 ]

Yield	Reaction Conditions	Operation in experiment
94%	With N-ethyl-N,N-diisopropylamine at 0℃; for 1h;	2.a Trifluoroacetic anhydride (7.35 g, 35.0 mmol) was added to a solution of 4-amino-2-methylthio-5- thiazolecarboxylic acid methyl ester (6.50 g, 31.8 mmol, commercially available from Fluorochem Products, West Columbia, SC) and N,N- diisopropylethylamine (4.52 g, 35.0 mmol) at O0C and the ice bath was removed. The mixture was then stirred for 1 hour, diluted with water, and the layers were separated. The organic layer was dried over MgSO4, concentrated in vacuo, and purified by column chromatography (EtOAc/hexane) to give the title compound in 94% yield. 1H NMR (400 MHz, CDCl3) δ ppm 10.78 (1 H, s), 3.91 (3 H, s), 2.76 (3 H, s).

Reference： [1]Current Patent Assignee: AMGEN INC - WO2008/137060, 2008, A1 Location in patent: Page/Page column 40

9
[ 1189-71-5 ]
[ 60093-05-2 ]
[ 1137279-03-8 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: isocyanate de chlorosulfonyle; thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methylester In dichloromethane at -78 - 0℃; for 0.5h; Stage #2: With hydrogenchloride; water at 100℃; for 0.5h; Stage #3: With water; sodium hydrogencarbonate; sodium carbonate at 20℃;	64 Example 64; 5-(2,7-Dimoφholinothiazolo[4,5-d]pyrimidin-5-yl)pyrimidin-2- amine 139[00379] In 150 mL methylene chloride, 4-amino-2-methylthio-5-thiazolcarboxylic acid methyl ester (0.05 mol) was dissolved and cooled to -78 °C under nitrogen gas. Stirring, 0.07 mol (1.4 eq) of chlorosulfonyl isocyanate was added slowly to give a brown solution. The reaction was warmed slowly to 0 °C and a white precipitate forms. After 30 minutes, the solution was evaporated under vacuum, resuspended in 40 mL of 6N hydrochloric acid (4 eq) and heated to 100 0C. After 30 minutes, the solution was cooled to room temp, neutralized with saturated sodium carbonate followed by saturated sodium bicarbonate. The white solid was isolated by filtration to give methyl 2-(methylthio)-4-ureidothiazole-5-carboxylate 76.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2009/42607, 2009, A1 Location in patent: Page/Page column 94

10
[ 60093-05-2 ]
[ 951804-64-1 ]

Yield	Reaction Conditions	Operation in experiment
43%	With Oxone In methanol; water at 5 - 20℃;	69A Example 69A; Methyl 4-amino-2-(methylsulphonyl)-1,3-thiazole-5-carboxylate 5.12 g (8.32 mmol) of Oxone are dissolved in 170 ml of water and cooled to 5° C. A solution of 1 g (4.90 mmol) of methyl 4-amino-2-(methylsulphanyl)-1,3-thiazole-5-carboxylate in 18 ml of methanol is then added dropwise, and the solution is stirred at RT for 3 h. The major amount of methanol is removed and extracted three times with dichloromethane. The combined organic phases are dried with sodium sulphate. After removal of the solvent and drying of the residue under high vacuum, the resulting solid (824 mg (43% of theory)) is employed without further purification.LCMS (method 3): Rt=1.52 min. (m/z=237 (M+H)+)1H-NMR (400 MHz, DMSO-d6): δ=7.36 (s, br, 2H), 3.79 (s, 3H), 3.45 (s, 3H).
43%	With Oxone In methanol; water at 5 - 20℃;	43A Methyl 4-amino-2-(methylsulfonyl)-1,3-thiazole-5-carboxylate Example 43A Methyl 4-amino-2-(methylsulfonyl)-1,3-thiazole-5-carboxylate 5.12 g (8.32 mmol) of Oxone were dissolved in 170 ml of water and cooled to 5° C. A solution of 1 g (4.90 mmol) of methyl 4-amino-2-(methylsulfanyl)-1,3-thiazole-5-carboxylate in 18 ml of methanol was then added dropwise, and the solution was stirred at RT for 3 h. Most of the methanol was removed, and the remainder was extracted three times with dichloromethane. The combined organic phases were dried with sodium sulfate. Following removal of the solvent and drying of the residue under high vacuum, the solid obtained (824 mg (43% of theory)) was used without further purification. LCMS (method 3): Rt=1.52 min. (m/z=237 (M+H)+). 1H-NMR (400 MHz, DMSO-d6): δ=7.36 (s, br, 2H), 3.79 (s, 3H), 3.45 (s, 3H).
	With Oxone In methanol; water at 20℃; for 24.5h;	2a 4-Amino-2-methanesulfonylthiazole-5-carboxylic Acid Methyl Ester 4-Amino-2-methanesulfonylthiazole-5-carboxylic Acid Methyl Ester After adding 45.2 g of 4-amino-2-methylsulfanylthiazole-5-carboxylic acid methyl ester [CAS No. 60093-05-2] to 2 l of a water:methanol=1:1 mixed solvent at room temperature, 408 g of Oxone was gradually added over a period of 30 minutes while stirring. Stirring was continued for 24 hours at room temperature, and then the reaction mixture was poured into a mixture of 10 l of ethyl acetate and 10 l of water. The organic layer was washed with 5 l of brine and dried over anhydrous magnesium sulfate. The desiccant was filtered out and the filtrate was concentrated under reduced pressure to obtain the target compound (37.6 g) as a colorless solid. 1H-NMR (CDCl3) δ 3.29 (s, 3H) 3.90 (s, 3H) 6.00 (br.s, 2H)

Reference： [1]Current Patent Assignee: BAYER AG - US2010/113441, 2010, A1 Location in patent: Page/Page column 41
[2]Current Patent Assignee: BAYER AG - US2011/53929, 2011, A1 Location in patent: Page/Page column 24
[3]Current Patent Assignee: EISAI CO LTD - US2009/270433, 2009, A1 Location in patent: Page/Page column 27

11
[ 42518-98-9 ]
[ 60093-05-2 ]
[ 929214-88-0 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; dmap In tetrahydrofuran at 55℃; Reflux;	28.A Methyl 4-[(5-chloro-2-thienyl)carbonyl]amino}-2-(methylthio)-1,3-thiazole-5-carboxylate Example 28A Methyl 4-[(5-chloro-2-thienyl)carbonyl]amino}-2-(methylthio)-1,3-thiazole-5-carboxylate 4.0 g (19.6 mmol) of methyl 4-amino-2-(methylthio)-1,3-thiazole-5-carboxylate are initially charged in 25 ml of THF and warmed to 55° C. 3.2 ml (3.1 g, 2.0 eq.) of pyridine and 239 mg (2.0 mmol, 0.1 eq.) of 4-N,N-dimethylaminopyridine are added to the solution. 5.3 g (29.4 mmol, 1.5 eq.) of the compound of Example 1A, dissolved in 25 ml of THF, are then added dropwise. The mixture is heated under reflux for 18 hours. After cooling to room temperature, 250 ml of water are added. The precipitate is separated off, washed with water, triturated with acetonitrile, filtered again, washed with cyclohexane and dried under reduced pressure. Yield: 5.7 g (72% purity, 60% of theory) LC-MS (Method 3): Rt=2.60 min; MS (ESIpos): m/z=349 [M+H]+.

Reference： [1]Current Patent Assignee: BAYER AG - US2010/4292, 2010, A1 Location in patent: Page/Page column 25

12
[ 1679-18-1 ]
[ 60093-05-2 ]
[ 515141-56-7 ]

Yield	Reaction Conditions	Operation in experiment
69%	With copper(I) salicylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ In tetrahydrofuran at 50℃; for 70h;

Reference： [1]McCoull, William; Barton, Peter; Broo, Anders; Brown, Alastair J. H.; Clarke, David S.; Coope, Gareth; Davies, Robert D. M.; Dossetter, Alexander G.; Kelly, Elizabeth E.; Knerr, Laurent; MacFaul, Philip; Holmes, Jane L.; Martin, Nathaniel; Moore, Jane E.; Morgan, David; Newton, Claire; Oesterlund, Krister; Robb, Graeme R.; Rosevere, Eleanor; Selmi, Nidhal; Stokes, Stephen; Svensson, Tor S.; Ullah, Victoria B. K.; Williams, Emma J. [MedChemComm, 2013, vol. 4, # 2, p. 456 - 462]

13
[ 60093-05-2 ]
[ 1078789-23-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / 1 h / 0 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C 3: methanol; sodium methylate / 1 h

Reference： [1]Current Patent Assignee: AMGEN INC - WO2008/137060, 2008, A1

14
[ 60093-05-2 ]
[ 1078789-98-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / 1 h / 0 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

Reference： [1]Current Patent Assignee: AMGEN INC - WO2008/137060, 2008, A1

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P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 60093-05-2 ]

Quality Control of [ 60093-05-2 ]

Related Doc. of [ 60093-05-2 ]

Product Details of [ 60093-05-2 ]

Calculated chemistry of of [ 60093-05-2 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 60093-05-2 ]

Application In Synthesis of [ 60093-05-2 ]

[ 60093-05-2 ] Synthesis Path-Upstream 1~2

[ 60093-05-2 ] Synthesis Path-Downstream 1~14

Related Functional Groups of [ 60093-05-2 ]

Sulfides

Amines

Esters

Related Parent Nucleus of [ 60093-05-2 ]

Thiazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 60093-05-2 ]

Related Parent Nucleus of
[ 60093-05-2 ]