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Chemical Structure| 601514-19-6 Chemical Structure| 601514-19-6

Structure of TWS119
CAS No.: 601514-19-6

Chemical Structure| 601514-19-6

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TWS119 is inhibitor of glycogen synthase kinase-3β with IC50 of 30 nM.

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Product Details of TWS119

CAS No. :601514-19-6
Formula : C18H14N4O2
M.W : 318.33
SMILES Code : OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1
MDL No. :MFCD09037535
InChI Key :VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Pubchem ID :9549289

Safety of TWS119

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Related Pathways of TWS119

PI3K-AKT
Hedgehog

Isoform Comparison

Biological Activity

Target
  • GSK-3β

    GSK-3β, IC50:30 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL

References

[1]Muralidharan S, Hanley PJ, et al. Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes. J Immunol. 2011 Nov 15;187(10):5221-32.

[2]Kordes C, Sawitza I, et al. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun. 2008 Feb 29;367(1):116-23.

[3] Wang W. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. doi: 10.1007/s12035-015-9607-2. Epub 2015 Dec 15.

[4]Wnt signaling pathway

[5] Ding S. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7. doi: 10.1073/pnas.0732087100. Epub 2003 Jun 6.

[6] Song D. Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke. J Neuroinflammation. 2019 Dec 6;16(1):256. doi: 10.1186/s12974-019-1660-8.

[7] Tang YY. Effects of Glycogen Synthase Kinase-3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer. J Immunother. 2018 Sep;41(7):319-328. doi: 10.1097/CJI.0000000000000234.

[8] Sun A. GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. Prostate. 2016 Feb;76(2):172-83. doi: 10.1002/pros.23106. Epub 2015 Oct 6.

[9] Chen YQ. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2018 Jan 1;362(1):63-71. doi: 10.1016/j.yexcr.2017.11.003. Epub 2017 Nov 16.

[10] Muralidharan S, Hanley PJ. Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes. J Immunol. 2011 Nov 15;187(10):5221-32. doi: 10.4049/jimmunol.1101585. Epub 2011 Oct 19.

 

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