[ CAS No. 60767-69-3 ]

Name: 4-Chloro-3-formylbenzenesulfonic acid
Brand: Ambeed
SKU: A109348
Rating: 99 (32 reviews)

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Quality Control of [ 60767-69-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 60767-69-3 ]

SDS

Alternatived Products of [ 60767-69-3 ]

Product Details of [ 60767-69-3 ]

CAS No. :	60767-69-3	MDL No. :	MFCD30717632
Formula :	C₇H₅ClO₄S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	220.63	Pubchem ID :	20462856
Synonyms :

Computed Properties of [ 60767-69-3 ]

TPSA :Topological Polar Surface Area	79.8	H-Bond Acceptor Count :	4
XLogP3 :	0.8	H-Bond Donor Count :	1
SP3 :	0.00	Rotatable Bond Count :	2

Safety of [ 60767-69-3 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	2585
Hazard Statements:	H290-H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 60767-69-3 ]

Upstream synthesis route of [ 60767-69-3 ]
Downstream synthetic route of [ 60767-69-3 ]

[ 60767-69-3 ] Synthesis Path-Upstream 1~2

1
[ 89-98-5 ]
[ 60767-69-3 ]

Reference： [1] Chemistry - A European Journal, 2017, vol. 23, # 62, p. 15628 - 15632
[2] Patent: US2006/224003, 2006, A1, . Location in patent: Page/Page column 3-4
[3] Patent: WO2017/118882, 2017, A1, . Location in patent: Page/Page column 9; 11

2
[ 104-88-1 ]
[ 89-98-5 ]
[ 60767-69-3 ]

Reference： [1] Patent: DE98229, , ,

[ 60767-69-3 ] Synthesis Path-Downstream 1~1

1
[ 89-98-5 ]
[ 60767-69-3 ]

Yield	Reaction Conditions	Operation in experiment
50%		100 g of 2-chlorobenzaldehyde was charged to 4 volumes of 20-25% of fuming sulphuric acid over a period of 1-2 hrs at 10-15 C. stirred the reaction mass temperature for 30-40 minutes at 10-15 and gradually raised the temperature to 25-30 C and then to 65-70 C. The obtained reaction mass was further stirred for 5-6 hrs at 65-70 C and quenched in cold water. To this 300 g of sodium chloride was added and stirred for 3-4 hrs at 25-30C. Filtered the precipitated solid and dried under vacuum at below 75C. Yield: 50% Purity: NLT 95%
	With sulfuric acid; sulfur trioxide; at 0 - 85℃; for 8.0h;	Preparation of 2-Chloro-1-formylbenzene-5-sulphonic acid (II) 2-chlorobenzaldehyde 500 g (3.35 moles) was added to 23% oleum 1050 g (1.35 moles), and the contents were cooled to 0 to 5 C. The reaction mixture was stirred for 2.5 hours between 0-15 C. To this stirred solution, 660 g of 65% oleum (2.41 moles) was added over a period of 2.5 hours, maintaining the temperature below 15 C. The reaction mass was stirred and allowed to come to a temperature of 25-30 C. The reaction mass was then heated to 80-85 C. and was maintained at that temperature for 3 hours. The reaction was monitored by HPLC. After completion of the reaction, the mass was quenched with 1500 gms of cold water over a period of two hours, maintaining the temperature below 40 C. It was further cooled to 20-25 C. At this temperature, finely powdered sodium chloride (1200 gms) was added under stirring. The reaction mass was further cooled to 0-5 C. and was stirred for three hours. The precipitated product was filtered and dried to give 1900 gms of the product including inorganics.
	With fuming sulphuric acid; at 10 - 80℃; for 5.0h;	139.2 gm (0.782M) 20% oleum was charged in to a 1L three neck RBF with overhead stirrer, dropping funnel and thermo pocket. lOOgm (0.711M) of 2-Chlorobenzaldehyde was added drop-wise between 10-20C. The reaction mass was stirred and allowed to come to temperature 25-30C. The reaction mass is heated to 70-80C and maintained for 5.0 hrs. The reaction was monitored by HPLC. After completion of reaction, quenched reaction mass in 3 L three neck RBF containing 1000 ml chilled water by maintaining temperature below 30C. To the mass 500 gm powdered sodium chloride was added and precipitated solid was stirred for 2.0 hrs and filtered to give 550 gm wet 2- chlorobenzaldehyde-5- sulfonic acid. It was added to 1400 ml water and pH of the solution was adjusted to 7-8 by using sodium carbonate. Sodium sulfite powder 206 gm (1.634M) was then added, followed by addition of sodium bisulfite 20.6 gm (0.198M) then reaction mass was heated to 100-105C and maintain for 6.0 hrs. The reaction was monitored by HPLC. After completion of reaction water was distilled off under vacuum below 80C. To the residue 500 ml methanol was added and stirred for 2.0 hrs. Filtered solid to obtain 725 g of benzaldehyde2, 5-disulfonic acid disodium salt having HPLC Purity greater than 90.0%

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 15628 - 15632
[2]Patent: WO2018/8040,2018,A1 .Location in patent: Page/Page column 17
[3]Patent: US2006/224003,2006,A1 .Location in patent: Page/Page column 3-4
[4]Patent: WO2017/118882,2017,A1 .Location in patent: Page/Page column 9; 11

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Ghs Precautionary Statements

Precautionary Statements-General
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Code	Phrase
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P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
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P243	Take precautionary measures against static discharge.
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P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
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P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
P402	Store in a dry place.
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P411
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P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 60767-69-3 ]

Quality Control of [ 60767-69-3 ]

Related Doc. of [ 60767-69-3 ]

Product Details of [ 60767-69-3 ]

Computed Properties of [ 60767-69-3 ]

Safety of [ 60767-69-3 ]

Application In Synthesis of [ 60767-69-3 ]

[ 60767-69-3 ] Synthesis Path-Upstream 1~2

[ 60767-69-3 ] Synthesis Path-Downstream 1~1

Related Functional Groups of [ 60767-69-3 ]

Chlorides

Sulfonic Acids

Aldehydes

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 60767-69-3 ]