Structure of Denosumab
CAS No.: 615258-40-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Denosumab is a humanized IgG2 monoclonal antibody that prevents RANKL from binding to the RANK receptor by binding to RANKL. Denosumab has potential for research in osteoporosis and bone metastases.
Synonyms: Immunoglobulin G2; Ranmark
4.5
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 615258-40-7 |
M.W : | 145.16 kDa |
SMILES Code : | NONE |
Synonyms : |
Immunoglobulin G2; Ranmark
|
MDL No. : | N/A |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319 |
Precautionary Statements: | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02444585 | Arthroplasty, Replacement, Hip | PHASE1 | WITHDRAWN | 2025-12-19 | Keck Medicine of USC, Los Ange... More >>les, California, 90033, United States Less << |
NCT03174366 | Charcot Joint of Foot | PHASE3 | COMPLETED | 2019-03-06 | Western University of Health S... More >>ciences, Pomona, California, 91711, United States Less << |
NCT02613416 | Breast Cancer | PHASE2 | COMPLETED | 2021-08-20 | Stony Brook University Cancer ... More >>Center, Stony Brook, New York, 11794, United States Less << |
NCT01799798 | Osteogenesis Imperfecta | PHASE2 | COMPLETED | 2025-01-15 | University Cologne, Childrens ... More >>Hospital, Cologne, Germany, Cologne, NRW, 50924, Germany Less << |
NCT00838201 | Cancer|Carcinoma|Castrate-Resi... More >>stant Prostate Cancer|Prostate Cancer|Tumors Less << | PHASE3 | COMPLETED | 2012-05-03 | Research Site, Huntsville, Ala... More >>bama, 35801, United States|Research Site, Anaheim, California, 92801, United States|Research Site, Laguna Hills, California, 92653, United States|Research Site, Long Beach, California, 90813, United States|Research Site, San Bernardino, California, 92404, United States|Research Site, San Diego, California, 92103, United States|Research Site, San Diego, California, 92120, United States|Research Site, Santa Monica, California, 90404, United States|Research Site, Middlebury, Connecticut, 06762, United States|Research Site, New Britain, Connecticut, 06052, United States|Research Site, Trinity, Florida, 34655, United States|Research Site, Fort Wayne, Indiana, 46825, United States|Research Site, Greenbelt, Maryland, 20770, United States|Research Site, Sartell, Minnesota, 56377, United States|Research Site, Omaha, Nebraska, 68114, United States|Research Site, Albany, New York, 12208, United States|Research Site, Bay Shore, New York, 11706, United States|Research Site, Garden City, New York, 11530, United States|Research Site, Poughkeepsie, New York, 12601, United States|Research Site, Lancaster, Pennsylvania, 17604, United States|Research Site, East Providence, Rhode Island, 02914, United States|Research Site, Myrtle Beach, South Carolina, 29572, United States|Research Site, Dallas, Texas, 75231, United States|Research Site, Salem, Virginia, 24153, United States|Research Site, Burien, Washington, 98166, United States|Research Site, Seattle, Washington, 98104, United States|Research Site, Tacoma, Washington, 98405, United States|Research Site, Calgary, Alberta, T2V 1P9, Canada|Research Site, Kelowna, British Columbia, V1Y 2H4, Canada|Research Site, Surrey, British Columbia, V3V 1N1, Canada|Research Site, Vancouver, British Columbia, V5Z 1M9, Canada|Research Site, Victoria, British Columbia, V8T 5G1, Canada|Research Site, Victoria, British Columbia, V8V 3N1, Canada|Research Site, Barrie, Ontario, L4M 7G1, Canada|Research Site, Brantford, Ontario, N3R 4N3, Canada|Research Site, Burlington, Ontario, L7N 3V2, Canada|Research Site, Burlington, Ontario, L7S 1V2, Canada|Research Site, Guelph, Ontario, N1H 5J1, Canada|Research Site, Kingston, Ontario, K7L 3J7, Canada|Research Site, Kitchener, Ontario, N2N 2B9, Canada|Research Site, London, Ontario, N6A 4G5, Canada|Research Site, Markham, Ontario, L6B 1A1, Canada|Research Site, Newmarket, Ontario, L3X 1W1, Canada|Research Site, North Bay, Ontario, P1B 7K8, Canada|Research Site, North York, Ontario, M2J 1V1, Canada|Research Site, Oakville, Ontario, L6H 3P1, Canada|Research Site, Oshawa, Ontario, L1H 7K4, Canada|Research Site, Scarborough, Ontario, M1P 2T7, Canada|Research Site, Sudbury, Ontario, P3E 4T3, Canada|Research Site, Toronto, Ontario, M2J 1V1, Canada|Research Site, Toronto, Ontario, M4N 3M5, Canada|Research Site, Toronto, Ontario, M6A 3B5, Canada|Research Site, Greenfield Park, Quebec, J4V 2H3, Canada|Research Site, Montreal, Quebec, H3G 1A4, Canada|Research Site, Seinajoki, 60220, Finland|Research Site, Tampere, 33520, Finland|Research Site, Balatonfured, 8230, Hungary|Research Site, Budapest, 1036, Hungary|Research Site, Budapest, 1204, Hungary|Research Site, Gyor, 9023, Hungary|Research Site, Nyiregyhaza, 4400, Hungary|Research Site, Mexico City, Distrito F, 07760, Mexico|Research Site, Mexico City, Distrito F, 14140, Mexico|Research Site, Toluca, 50120, Mexico|Research Site, Veracruz, 91700, Mexico|Research Site, Bialystok, 15-276, Poland|Research Site, Bydgoszcz, 85-171, Poland|Research Site, Lublin, 20-718, Poland|Research Site, Lublin, 20-954, Poland|Research Site, Opole, 45-086, Poland|Research Site, Siedlce, 08-110, Poland|Research Site, Warszawa, 00-416, Poland|Research Site, Warszawa, 02-781, Poland|Research Site, Wroclaw, 50-088, Poland Less << |
NCT02903446 | Gout | PHASE2 | COMPLETED | 2020-03-01 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States Less << |
NCT02422108 | Testis|Infertility|Sperm | PHASE2 | COMPLETED | 2025-01-19 | Rigshospitalet, Copenhagen, 21... More >>00, Denmark Less << |
NCT05435768 | Metastatic Solid Tumor | NOT_YET_RECRUITING | 2025-08-15 | The Second Affiliated Hospital... More >> of Soochow University, Suzhou, Jiangsu, 215004, China Less << | |
NCT02491515 | Osteoporosis | UNKNOWN | 2025-12-20 | Tomidahama Hospital, Yokkaichi... More >>, Mie, 510-8008, Japan Less << | |
NCT03358212 | Giant Cell Tumor of Bone | UNKNOWN | 2021-06-01 | - | |
NCT05402865 | Giant Cell Tumor of Bone | COMPLETED | 2022-02-18 | Beijing Jishuitan Hospital, Be... More >>ijing, Beijing, 100035, China|Peking University Third Hospital, Beijing, Beijing, 100191, China|West China Hospital of Sichuan University, Beijing, Beijing, 610044, China Less << | |
NCT03301857 | Giant Cell Tumor of Bone | PHASE4 | COMPLETED | 2023-07-27 | Sarcoma Oncology Research Cent... More >>er LLC, Santa Monica, California, 90403, United States|Washington Cancer Institute at MedStar Washington Hospital, Washington, District of Columbia, 20010, United States|University of Minnesota Medical Center Fairview, Minneapolis, Minnesota, 55455, United States|Mount Sinai Beth Israel Downtown, New York, New York, 10003, United States|Abramson Cancer Center at Pennsylvania Hospital, Philadelphia, Pennsylvania, 19106, United States|Royal Prince Alfred Hospital, Camperdown, New South Wales, 2050, Australia|Centre Leon Berard, Lyon CEDEX 08, 69373, France|Institut Gustave Roussy, Villejuif, 94805, France|Istituti Ortopedici Rizzoli, Bologna, 40136, Italy|Instytut Matki i Dziecka, Warszawa, 01-211, Poland|Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie a€" Panstwowy Instytut Badawczy, Warszawa, 02-781, Poland|Hospital Universitari Son Espases, Palma de Mallorca, Baleares, 07010, Spain|Skane Universitetssjukhus, Lund, 221 85, Sweden|Royal Orthopaedic Hospital, Birmingham, B31 2AP, United Kingdom Less << |
NCT02321280 | Crohn Disease | PHASE1|PHASE2 | COMPLETED | 2018-04-20 | University of Manitoba, Winnip... More >>eg, Manitoba, R3A 1R9, Canada Less << |
NCT01464931 | Renal Impairment | PHASE1 | COMPLETED | 2025-03-13 | Research Site, Tempe, Arizona,... More >> 85284, United States|Research Site, Denver, Colorado, 80230, United States|Research Site, Pembroke Pines, Florida, 33028, United States|Research Site, Meridian, Idaho, 83642, United States|Research Site, Detroit, Michigan, 48236, United States|Research Site, Orangeburg, South Carolina, 29118, United States|Research Site, San Antonio, Texas, 78215, United States Less << |
NCT02853539 | Metabolic Bone Disease | PHASE4 | COMPLETED | 2025-07-16 | Stanley Dudrick's Memorial Hos... More >>pital, Skawina, 32-050, Poland Less << |
NCT00680992 | Cancer|Giant Cell Tumors|Giant... More >> Cell Tumor of Bone|Benign Giant Cell Tumors Less << | PHASE2 | COMPLETED | 2018-05-17 | Research Site, Santa Monica, C... More >>alifornia, 90403, United States|Research Site, Stanford, California, 94305, United States|Research Site, Washington, District of Columbia, 20010, United States|Research Site, Gainesville, Florida, 32607, United States|Research Site, Boston, Massachusetts, 02114, United States|Research Site, Boston, Massachusetts, 02215, United States|Research Site, Ann Arbor, Michigan, 48109, United States|Research Site, Minneapolis, Minnesota, 55455, United States|Research Site, New York, New York, 10003, United States|Research Site, Philadelphia, Pennsylvania, 19106, United States|Research Site, Greenville, South Carolina, 29605, United States|Research Site, Camperdown, New South Wales, 2250, Australia|Research Site, Woolloongabba, Queensland, 4102, Australia|Research Site, East Melbourne, Victoria, 3002, Australia|Research Site, Nedlands, Western Australia, 6009, Australia|Research Site, Wien, 1090, Austria|Research Site, Toronto, Ontario, M5G 1X5, Canada|Research Site, Montreal, Quebec, H4A 3J1, Canada|Research Site, Lyon cedex 8, 69373, France|Research Site, Marseille cedex 05, 13385, France|Research Site, Villejuif cedex, 94805, France|Research Site, Bad Saarow, 15526, Germany|Research Site, Stuttgart, 70174, Germany|Research Site, Bologna, 40136, Italy|Research Site, Milano, 20133, Italy|Research Site, Leiden, 2333 ZA, Netherlands|Research Site, Warszawa, 01-211, Poland|Research Site, Warszawa, 02-781, Poland|Research Site, Palma de Mallorca, Baleares, 07010, Spain|Research Site, Barcelona, Catalu?a, 08025, Spain|Research Site, Valencia, Comunidad Valenciana, 46026, Spain|Research Site, Lund, 221 85, Sweden|Research Site, Birmingham, B31 2AP, United Kingdom Less << |
NCT03605199 | Aneurysmal Bone Cysts|Giant Ce... More >>ll Granuloma|Osteoblastoma|Chondroblastoma|Chondromyxoid Fibroma Less << | PHASE2 | UNKNOWN | 2025-06-23 | Centre Léon Bérard, Lyon, Fran... More >>ce|Istituto Ortopedico Rizzoli, Bologna, Italy|Leiden University Medical Center, Leiden, Netherlands Less << |
NCT06357741 | Knee Osteoarthritis | COMPLETED | 2024-03-10 | Wuhan Union Hospital, Wuhan, H... More >>ubei, 430000, China Less << | |
NCT04621318 | Healthy | PHASE1 | COMPLETED | 2022-11-09 | Biotrial, Newark, New Jersey, ... More >>07103, United States|Biotrial Rennes, Rennes, France Less << |
NCT03030196 | Infertility, Male | PHASE2 | COMPLETED | 2025-05-23 | Department of Growth and Repro... More >>duction, Rigshospitalet, Copenhagen, 2100, Denmark Less << |
NCT03259152 | Giant Cell Tumor of Bone | PHASE3 | UNKNOWN | 2019-05-01 | Zhuang Zhou, Shijiazhuang, Heb... More >>ei, 050000, China Less << |
NCT03571191 | Bone Diseases|Pain | PHASE2 | ACTIVE_NOT_RECRUITING | 2030-03-15 | National Institutes of Health ... More >>Clinical Center, Bethesda, Maryland, 20892, United States Less << |
NCT02049866 | Adult Idiopathic Generalized O... More >>steoporosis Less << | PHASE2 | COMPLETED | 2021-12-23 | Creighton University, Omaha, N... More >>ebraska, 68131, United States|Columbia University Medical Center, New York, New York, 10032, United States Less << |
NCT03921060 | Cystic Fibrosis | PHASE4 | RECRUITING | 2025-07-27 | UT Southwestern Medical Center... More >>, Dallas, Texas, 75390, United States Less << |
NCT01952054 | Breast Cancer | PHASE2 | TERMINATED | 2018-10-10 | University of Texas MD Anderso... More >>n Cancer Center, Houston, Texas, 77030, United States Less << |
NCT01545648 | Early Stage Breast Cancer | PHASE2 | TERMINATED | 2016-06-09 | University of California San F... More >>rancisco, San Francisco, California, 94143, United States Less << |
NCT02677246 | Disorder Related to Bone Marro... More >>w Transplantation Less << | PHASE1 | WITHDRAWN | 2018-09-04 | St. Justine 's Hospital, Montr... More >>eal, Quebec, H3T1C5, Canada Less << |
NCT01419717 | Bone Metastases in Men With Ho... More >>rmone-Refractory Prostate Cancer|Bone Metastases in Subjects With Advanced Breast Cancer Less << | PHASE3 | COMPLETED | 2018-08-10 | Research Site, Capital Federal... More >>, Buenos Aires, C1426ANZ, Argentina|Research Site, Quilmes, Buenos Aires, B1878GEG, Argentina|Research Site, Cordoba, Córdoba, X5016KEH, Argentina|Research Site, Rosario, Santa Fe, S2000PBJ, Argentina|Research Site, Wien, 1090, Austria|Research Site, Namur, 5000, Belgium|Research Site, Porto Alegre, Rio Grande Do Sul, 90035-003, Brazil|Research Site, Porto Alegre, Rio Grande Do Sul, 90610-000, Brazil|Research Site, Santo Andre, S?o Paulo, 09060-650, Brazil|Research Site, Sao Paulo, S?o Paulo, 01221-020, Brazil|Research Site, Sao Paulo, S?o Paulo, 01509-900, Brazil|Research Site, Sao Paulo, S?o Paulo, 04262-000, Brazil|Research Site, Sorocaba, S?o Paulo, 18030-200, Brazil|Research Site, Rio de Janeiro, 20551-030, Brazil|Research Site, Rio de Janeiro, 22640-000, Brazil|Research Site, S?o Paulo, 01209-000, Brazil|Research Site, Kromeriz, 767 55, Czechia|Research Site, Olomouc, 775 20, Czechia|Research Site, Praha 1, 110 00, Czechia|Research Site, Praha 4, 140 00, Czechia|Research Site, Praha 4, 140 44, Czechia|Research Site, Praha 5, 150 06, Czechia|Research Site, Saint Cloud, 92210, France|Research Site, Debrecen, 4012, Hungary|Research Site, Dombovar, 7200, Hungary|Research Site, Haifa, 31096, Israel|Research Site, Rehovot, 76100, Israel|Research Site, Tel-Aviv, 64239, Israel|Research Site, Zerifin, 70300, Israel|Research Site, Meldola (FC), 47014, Italy|Research Site, Sora, 03039, Italy|Research Site, Kure-shi, Hiroshima, 737-0023, Japan|Research Site, Kagoshima-shi, Kagoshima, 892-0833, Japan|Research Site, Isehara-shi, Kanagawa, 259-1193, Japan|Research Site, Osaka-shi, Osaka, 540-0006, Japan|Research Site, Kitaadachi-gun, Saitama, 362-0806, Japan|Research Site, Chuo-ku, Tokyo, 104-0045, Japan|Research Site, Tokyo, 135-8550, Japan|Research Site, Daugavpils, 5417, Latvia|Research Site, Riga, 1079, Latvia|Research Site, Kaunas, 50009, Lithuania|Research Site, Vilnius, 08660, Lithuania|Research Site, Panama, Panama|Research Site, Lima, Lima 18, Peru|Research Site, Lima, Lima 27, Peru|Research Site, Bialystok, 15-027, Poland|Research Site, Bydgoszcz, 85-171, Poland|Research Site, Gdansk, 80-952, Poland|Research Site, Lublin, 20-954, Poland|Research Site, Poznan, 61-866, Poland|Research Site, Warszawa, 00-631, Poland|Research Site, Arkhangelsk, 163045, Russian Federation|Research Site, Chelyabinsk, 454087, Russian Federation|Research Site, Krasnogorsky District, 143423, Russian Federation|Research Site, Moscow, 115478, Russian Federation|Research Site, Obninsk, 249036, Russian Federation|Research Site, Omsk, 644013, Russian Federation|Research Site, St Petersburg, 197089, Russian Federation|Research Site, Pretoria, 0081, South Africa|Research Site, Sevilla, Andalucía, 41013, Spain|Research Site, Valencia, Comunidad Valenciana, 46009, Spain|Research Site, Madrid, 28034, Spain|Research Site, Madrid, 28040, Spain|Research Site, Lviv, 79031, Ukraine Less << |
NCT02352753 | Osteogenesis Imperfecta | PHASE3 | TERMINATED | 2022-03-26 | Research Site, Los Angeles, Ca... More >>lifornia, 90027, United States|Research Site, Torrance, California, 90502, United States|Research Site, Aurora, Colorado, 80045, United States|Research Site, New Haven, Connecticut, 06510, United States|Research Site, Wilmington, Delaware, 19803, United States|Research Site, Decatur, Georgia, 30033, United States|Research Site, Indianapolis, Indiana, 46202, United States|Research Site, Iowa City, Iowa, 52242, United States|Research Site, Baltimore, Maryland, 21205, United States|Research Site, Boston, Massachusetts, 02115, United States|Research Site, Omaha, Nebraska, 68114, United States|Research Site, Nashville, Tennessee, 37232, United States|Research Site, Houston, Texas, 77030, United States|Research Site, Westmead, New South Wales, 2145, Australia|Research Site, Subiaco, Western Australia, 6008, Australia|Research Site, Bruxelles, 1200, Belgium|Research Site, Gent, 9000, Belgium|Research Site, Leuven, 3000, Belgium|Research Site, Sofia, 1606, Bulgaria|Research Site, Sofia, 1784, Bulgaria|Research Site, Varna, 9010, Bulgaria|Research Site, Ottawa, Ontario, K1H 8L1, Canada|Research Site, Toronto, Ontario, M5G 1X8, Canada|Research Site, Montreal, Quebec, H4A 0A9, Canada|Research Site, Hradec Kralove, 500 05, Czechia|Research Site, Pardubice, 532 03, Czechia|Research Site, Plzen, 305 99, Czechia|Research Site, Praha 4, 140 59, Czechia|Research Site, Zlin, 762 75, Czechia|Research Site, Bordeaux Cedex, 33076, France|Research Site, Paris Cedex 15, 75743, France|Research Site, Paris, 75012, France|Research Site, Saint Priest en Jarez, 42270, France|Research Site, Toulouse Cedex 9, 31059, France|Research Site, K?ln, 50931, Germany|Research Site, Budapest, 1094, Hungary|Research Site, Roma, 00161, Italy|Research Site, Verona, 37126, Italy|Research Site, Bialystok, 15-274, Poland|Research Site, Lodz, 91-738, Poland|Research Site, Rzeszow, 35-301, Poland|Research Site, Warszawa, 04-730, Poland|Research Site, Esplugues de Llobregat, Catalu?a, 08950, Spain|Research Site, Valencia, Comunidad Valenciana, 46026, Spain|Research Site, Getafe, Madrid, 28905, Spain|Research Site, Birmingham, B4 6NH, United Kingdom|Research Site, Bristol, BS2 8AE, United Kingdom|Research Site, Glasgow, G51 4TF, United Kingdom|Research Site, Sheffield, S10 2TH, United Kingdom Less << |
NCT05091086 | Osteoporosis|Bone Mineral Dens... More >>ity Less << | PHASE4 | RECRUITING | 2030-12-31 | National Taiwan University Hos... More >>pital, Yunlin branch, Douliu, Yunlin County, 640, Taiwan Less << |
NCT03839459 | Smoldering Multiple Myeloma | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-06-01 | University of Rochester, Roche... More >>ster, New York, 14642, United States Less << |
NCT01864798 | Breast Neoplasms | PHASE2 | TERMINATED | 2025-01-17 | Royal Melbourne Hospital, Vict... More >>oria, 3050, Australia|Institute Jules Bordet, Brussels, 1000, Belgium|Hopital Erasme, Brussels, 1070, Belgium|UZ Leuven, Leuven, 3000, Belgium|CHU Ambroise Paré, Mons, 7000, Belgium|CMSE, Namur, 5000, Belgium Less << |
Tags: Denosumab | Immunoglobulin G2 | RANKL /monoclonal antibody | RANKL | NF-κB | NF-κB | Parkinson'S Disease and Alzheimer'S Disease | Cancer Stem Cells | PPAR Signaling Pathway | Wnt Signaling Pathway | Pyroptosis | Human Inhibitory Monoclonal Antibody | 615258-40-7
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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