Alternatived Products of [ 61539-35-3 ]
Product Details of [ 61539-35-3 ]
CAS No. : | 61539-35-3 |
MDL No. : | |
Formula : |
C10H9ClO4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
228.63
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 61539-35-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 61539-35-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 61539-35-3 ]
- 1
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[ 61539-35-3 ]
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[ 37418-88-5 ]
Yield | Reaction Conditions | Operation in experiment |
188.9 g |
Stage #1: 3-chlorophthalic acid dimethyl ester With copper(I) bromide; sodium hydroxide In dimethyl sulfoxide at 100℃; for 5h;
Stage #2: With phosphorus pentoxide In dimethyl sulfoxide at 120℃; for 2h; |
5
3-Chlorophthalic acid methyl ester (229.0 g, L0 mol) and dimethyl sulfoxide (800 mL) were added to a three-necked flask and stirring was started;Sodium hydroxide (140.0g, 3.5mol) and cuprous bromide (1.43g, 0 · Olmol) were added to the reaction, and the temperature was raised to 100 ° C for 5 hours.TLC monitoring (methanol: dichloromethane = 1: 1, v / v) to complete reaction, drop to room temperature, filter;The filtrate with 6. 0mOl / L hydrochloric acid to adjust the pH value of between 1.0 to 2.0, the filtrate transferred to three bottles, stirring, adding phosphorus pentoxide (355. 0g, 2. 5mol), heated to 120 ° C insulation reaction 2 hours;TLC monitoring (methanol: dichloromethane = 1: 1, v / v) to room temperature when the reaction was complete;The organic phase was extracted with ethyl acetate (800 mLX3), dried over anhydrous magnesium sulfate and filtered to give 188. 9 g of 3-hydroxyphthalic anhydride as a white solid. The conversion was 82.5% and HPLC purity was 96 . 2%. |