Alternatived Products of [ 6400-14-2 ]
Product Details of [ 6400-14-2 ]
CAS No. : | 6400-14-2 |
MDL No. : | MFCD19203555 |
Formula : |
C6H7ClN2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
142.59
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 6400-14-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 6400-14-2 ]
- 1
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[ 6400-14-2 ]
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[ 56-81-5 ]
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[ 1379334-91-4 ]
Yield | Reaction Conditions | Operation in experiment |
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Stage #1: 2-chloro-1,3-phenylenediamine; glycerol With sulfuric acid; sodium iodide at 150 - 170℃; for 5h;
Stage #2: With sodium hydroxide In water |
3
To a mixture of 2-chlorobenzene-1 ,3-diamine (24 mmol) (CAS 6400-14-2) and Nal (150 mg) in 80% H2SO4 (20 g) was added Glycerol (45 g). The mixture was stirred at 150°C to 170°C for 5 h. The mixture was cooled to room temperature. Aqueous 5N NaOH was used to adjust the pH to alkaline, which was then extracted with EtOAc washed with brine, dried over MgSO and concentrated under reduced vacuum. Flash column chromatography (EtOAc:Hexane) yielded 7-amino-8-chloroquinoline (800 mg), as a pale yellow solid. 1 H NMR (300 MHz, CD3OD) δ: 8.69 (dd, J = 4.4, 1 .8 Hz, 1 H), 8.13 (dd, J = 7.9, 1 .8 Hz, 1 H), 7.61 (d, J = 9.1 Hz, 1 H), 7.14 - 7.29 (m, 2H) |