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Chemistry
Organic Building Blocks
Amines
3-(Isopropylamino)propane-1,2-diol
Chemistry
Organic Building Blocks
Amines
Alcohols Aliphatic Chain Hydrocarbons

[ CAS No. 6452-57-9 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 6452-57-9
Chemical Structure| 6452-57-9
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Quality Control of [ 6452-57-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 6452-57-9 ]

Product Details of [ 6452-57-9 ]

CAS No. :6452-57-9 MDL No. :MFCD00128146
Formula : C6H15NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :133.19 Pubchem ID :-
Synonyms :

Safety of [ 6452-57-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P273-P280-P305+P351+P338-P310 UN#:2735
Hazard Statements:H314-H332-H335-H412 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 6452-57-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6452-57-9 ]

[ 6452-57-9 ] Synthesis Path-Downstream   1~37

  • 1
  • [ 28141-24-4 ]
  • [ 6452-57-9 ]
  • [ 83231-21-4 ]
YieldReaction ConditionsOperation in experiment
62% With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 2
  • [ 25054-53-9 ]
  • [ 6452-57-9 ]
  • [ 90531-36-5 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 3
  • [ 1486-50-6 ]
  • [ 6452-57-9 ]
  • [ 90531-49-0 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 4
  • [ 6452-57-9 ]
  • [ 52542-42-4 ]
  • [ 83230-84-6 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 5
  • [ 6452-57-9 ]
  • [ 54090-36-7 ]
  • [ 83230-87-9 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 6
  • [ 6452-57-9 ]
  • [ 21563-72-4 ]
  • [ 90531-44-5 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 7
  • [ 6452-57-9 ]
  • [ 83230-74-4 ]
  • [ 90531-42-3 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 8
  • [ 6452-57-9 ]
  • [ 90531-74-1 ]
  • [ 83231-33-8 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 9
  • [ 6452-57-9 ]
  • [ 83230-73-3 ]
  • [ 90531-43-4 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 10
  • [ 6452-57-9 ]
  • [ 90531-75-2 ]
  • [ 83231-35-0 ]
YieldReaction ConditionsOperation in experiment
6% With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 11
  • [ 556-52-5 ]
  • [ 75-31-0 ]
  • [ 6452-57-9 ]
YieldReaction ConditionsOperation in experiment
In ethanol for 3h; Ambient temperature;
In isopropyl alcohol 1.) 70 deg C, 1.5 h, 2.) RT, 15 h;
53 g at 25℃;
I.a 3-(Isopropylamino)-1,2-propanediol 3-(Isopropylamino)-1,2-propanediol A mixture of 37 g (0.5 mole) of glycidol and 35.4 g (0.6 mole) of isopropylamine was stirred at 25° C. overnight. Excess isopropylamine was evaporated in vacuo and the mixture was distilled to give 53 g of product: b.p. 80° C./0.1 mm Hg. The NMR and IR spectra were consistent with the assigned structure and the elemental analysis was consistent with the empirical formula C6 H15 O2 N.
XIV 3-(Isopropylamino)-1,2-propanediol 3-(Isopropylamino)-1,2-propanediol A mixture of 37 g (0.5 mole) of glycidol and 35.4 g (0.6 mole) of isopropylamine was stirred at 25° overnight. Excess isopropylamine was evaporated in vacuo and the mixture was distilled to give 53 g of product: b.p. 80° C./0.1 mm Hg. The NMR and IR spectra were consistent with the assigned structure and the elemental analysis was consistent with the empirical formula C6 H15 O2 N.
In ethanol at 20℃; for 5h; 146.A Part A: 3-(isopropylamino)propane-1,2-diol To propan-2-amine (0.399 g, 6.75 mmol) in ethanol (2 mL) was added oxiran- 2-ylmethanol (0.5 g, 6.75 mmol) slowly. The mixture was stirred at room temperature for 5 h. The crude reaction mixture was concentrated under reduced pressure to afford 3-(isopropylamino)propane-l,2-diol (0.82 g, 6.16 mmol, 91 % crude yield) as a brownish color semi-solid which was carried forward without further purification. LC/MS (ESI) m/e 133.9 [(M+H)+, calcd for C6Hi6N02 134.2]; 1H NMR (400MHz, CDC13) δ 3.76 - 3.49 (m, 3H), 2.89 - 2.60 (m, 3H), 2.04 (br s, 3H), 1.08 (d, J=6.4 Hz, 3H), 1.06 (d, J=6.4 Hz, 3H).

Reference： [1]Leclerc, Gerard; Bieth, Nicole; Schwartz, Jean [Journal of Medicinal Chemistry, 1980, vol. 23, # 6, p. 620 - 624]
[2]Baldwin; Denny; Hirschmann; Freedman; Ponticello; Gross; Sweet [Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 950 - 957]
[3]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
[4]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US4402974, 1983, A
[5]Current Patent Assignee: BAXTER INTERNATIONAL INC; BECTON DICKINSON & CO - US4405642, 1983, A
[6]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - WO2015/116060, 2015, A1 Location in patent: Page/Page column 308
  • 12
  • [ 6452-57-9 ]
  • [ 403-43-0 ]
  • [ 90531-46-7 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 13
  • [ 6452-57-9 ]
  • [ 609-65-4 ]
  • [ 85515-32-8 ]
YieldReaction ConditionsOperation in experiment
With pyridine; pyridine hydrochloride for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 14
  • [ 6452-57-9 ]
  • [ 6068-72-0 ]
  • [ 90531-52-5 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 15
  • [ 6452-57-9 ]
  • [ 100-52-7 ]
  • [ 54126-58-8 ]
YieldReaction ConditionsOperation in experiment
With benzoic acid In toluene for 3h; Heating;
Reference： [1]Baldwin; Denny; Hirschmann; Freedman; Ponticello; Gross; Sweet [Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 950 - 957]
  • 16
  • [ 6452-57-9 ]
  • [ 100-07-2 ]
  • [ 90531-48-9 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 17
  • [ 6452-57-9 ]
  • [ 122-04-3 ]
  • [ 90531-51-4 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 18
  • [ 6452-57-9 ]
  • [ 933-88-0 ]
  • [ 90531-39-8 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 19
  • [ 6452-57-9 ]
  • [ 16331-48-9 ]
  • [ 83231-45-2 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 20
  • [ 6452-57-9 ]
  • [ 16106-38-0 ]
  • [ 90531-50-3 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 21
  • [ 6452-57-9 ]
  • [ 1711-07-5 ]
  • [ 90531-40-1 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 22
  • [ 6452-57-9 ]
  • [ 393-52-2 ]
  • [ 90531-38-7 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 23
  • [ 6452-57-9 ]
  • [ 879-18-5 ]
  • [ 90531-53-6 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 24
  • [ 6452-57-9 ]
  • [ 121-90-4 ]
  • [ 90531-45-6 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
  • 25
  • [ 6452-57-9 ]
  • [ 2243-83-6 ]
  • [ 90531-54-7 ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene for 2h; Ambient temperature;
Reference： [1]Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. [Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1007 - 1016]
YieldReaction ConditionsOperation in experiment
1,2-Dihydroxy-3-chlor-propan, i-Propylamin;
  • 27
  • [ 6452-57-9 ]
  • [ 85613-37-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: benzoic acid / toluene / 3 h / Heating 2: pyridine / 3 h / 25 °C 3: 1.) NaH / 1.) DMF, 60 deg C, 0.5 h, 2.) DMF, reflux, 16 h 4: 1 N HCl, NaOAc / 5 h / Ambient temperature
Reference： [1]Baldwin; Denny; Hirschmann; Freedman; Ponticello; Gross; Sweet [Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 950 - 957]
  • 28
  • [ 6452-57-9 ]
  • 3-Isopropyl-2-phenyl-5-[4-(5-thiophen-2-yl-1H-imidazol-2-yl)-phenoxymethyl]-oxazolidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: benzoic acid / toluene / 3 h / Heating 2: pyridine / 3 h / 25 °C 3: 1.) NaH / 1.) DMF, 60 deg C, 0.5 h, 2.) DMF, reflux, 16 h
Reference： [1]Baldwin; Denny; Hirschmann; Freedman; Ponticello; Gross; Sweet [Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 950 - 957]
  • 29
  • [ 6452-57-9 ]
  • [ 90743-11-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: benzoic acid / toluene / 3 h / Heating 2: pyridine / 3 h / 25 °C
Reference： [1]Baldwin; Denny; Hirschmann; Freedman; Ponticello; Gross; Sweet [Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 950 - 957]
  • 30
  • 4'-isopropylaminomethyl-5-bromo-4,5,6,7-tetrahydrobenzothiazole-6-spiro-2'-[1,3]-dioxolane [ No CAS ]
  • aqueous 2.5N-sodium hydroxide [ No CAS ]
  • 6-oxo-5-bromo-4,5,6,7-tetrahydrobenzothiazole [ No CAS ]
  • [ 6452-57-9 ]
  • [ 55982-34-8 ]
YieldReaction ConditionsOperation in experiment
57% With p-toluenesulfonic acid monohydrate In piperidine; toluene VII.a (a) (a) 6-(3-Isopropylamino-2-hydroxypropoxy)benzothiazole STR122 A mixture of 6-oxo-5-bromo-4,5,6,7-tetrahydrobenzothiazole (100 parts), 3-isopropylamino-1,2-propanediol (67 parts), p-toluenesulfonic acid monohydrate (99 parts) and toluene (1550 parts) is heated under reflux for 21 hours while drying the refluxing azeotropic mixture according to the method described in Example I. After cooling, the reaction mixture is adjusted to pH 9 by adding aqueous 2.5N-sodium hydroxide and formed organic layer is separated. The organic layer is washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The remaining 4'-isopropylaminomethyl-5-bromo-4,5,6,7-tetrahydrobenzothiazole-6-spiro-2'-[1,3]-dioxolane (156 parts) is dissolved in piperidine (1560 parts), and stirred for 49 hours on an oil bath heated at 95° to 100° C. The reaction mixture is concentrated under reduced pressure to leave residue which is mixed with ethyl acetate and water, shaken and fractionated to separate formed organic layer. The organic layer is washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Residue (172 parts) is recrystallized from ethanol-hydrochloric acid giving 6-(3-isopropylamino-2-hydroxypropoxy)benzothiazole) (65 parts) in 57% yield. mp. 132°-134° C. (hydrochloride trihydrate).
Reference： [1]Current Patent Assignee: SHIONOGI & CO., LTD. - US4506079, 1985, A
  • 31
  • [ 6452-57-9 ]
  • [ 616-38-6 ]
  • [ 83277-30-9 ]
YieldReaction ConditionsOperation in experiment
With sodium methylate In methanol Industry scale; 1.1 A reactor is charged with 392 kg of isopropylaminopropanediol, approximately 240 L of methanol, 6 to 7L of sodium methoxide (30%) and 270 L of dimethylcarbonate. The contents were heated up to allow reaction to occur. Solvent is removed by distillation.200 L water and ca 450 L of methylisobutylketone (MIBK) are then charged to the reactor. The reactor contents are then cooled down to <25°C. Tetrabutylammoniumhydrogensulphate (ca 2.5kg) and 520 kg of benzenesulphonylchloride are then added to the vessel under cooling. 30% sodium hydroxide is added to the reactorThe reactor contents are heated and phase separation performed, removing the aqueous layer. Solvent is distilled and the product oxazolidone sulphonate is isolated from methyl-tert-butylether (MTBE).Fig. 1 illustrates the infra red spectrum of oxazolidinone sulphate.Purity HPLC >98%
Reference： [1]Current Patent Assignee: INTERNATIONAL CHEMICALS INVESTORS SE - WO2010/61366, 2010, A1 Location in patent: Page/Page column 6-7
  • 32
  • [ 51384-51-1 ]
  • [ 6452-57-9 ]
  • 3-hydroxy-4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}benzaldehyde [ No CAS ]
  • 1-[4-(1-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol [ No CAS ]
  • 2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]-N-(propan-2-yl)propanamide [ No CAS ]
  • 4-(2-methoxyethyl)phenyl 2-hydroxy-3-(propan-2-ylamino)propanoate [ No CAS ]
  • 1-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}-2-methoxyethane-1,2-diol [ No CAS ]
  • [ 29121-23-1 ]
  • [ 110458-45-2 ]
YieldReaction ConditionsOperation in experiment
With titanium(IV) oxide; oxygen UV-irradiation;
Reference： [1]Armaković; Armaković; Finčur; Šibul; Vione; Šetrajčić; Abramović [RSC Advances, 2015, vol. 5, # 67, p. 54589 - 54604]
  • 33
  • [ 51384-51-1 ]
  • [ 6452-57-9 ]
  • 1-[4-(1-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol [ No CAS ]
  • 2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]-N-(propan-2-yl)propanamide [ No CAS ]
  • 4-(2-methoxyethyl)phenyl 2-hydroxy-3-(propan-2-ylamino)propanoate [ No CAS ]
  • 1-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}-2-methoxyethane-1,2-diol [ No CAS ]
  • [ 29121-23-1 ]
  • [ 110458-45-2 ]
YieldReaction ConditionsOperation in experiment
With P25; dihydrogen peroxide; oxygen UV-irradiation;
Reference： [1]Armaković; Armaković; Finčur; Šibul; Vione; Šetrajčić; Abramović [RSC Advances, 2015, vol. 5, # 67, p. 54589 - 54604]
  • 34
  • [ 525-66-6 ]
  • [ 6452-57-9 ]
  • C16H19NO3 [ No CAS ]
  • C16H21NO4 [ No CAS ]
  • C16H23NO4 [ No CAS ]
  • C16H21NO5 [ No CAS ]
  • C16H23NO5 [ No CAS ]
  • [ 84418-31-5 ]
  • [ 88-99-3 ]
YieldReaction ConditionsOperation in experiment
With dihydrogen peroxide In aq. phosphate buffer at 20℃; UV-irradiation; Photolysis;
Reference： [1]Yang, Yi; Cao, Ying; Jiang, Jin; Lu, Xinglin; Ma, Jun; Pang, Suyan; Li, Juan; Liu, Yongze; Zhou, Yang; Guan, Chaoting [Water Research, 2019, vol. 149, p. 543 - 552]
  • 35
  • [ 6452-57-9 ]
  • [ 177034-57-0 ]
  • bisoprolol [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With diamide In dichloromethane at 25℃; Inert atmosphere; 1-3 Example 2 Under the protection of nitrogen, add 500ml of dichloromethane, 100g of 4-isopropoxyethoxymethylphenol, 190g of 3-isopropylamino-1,2-propanediol and 374.7g of triphenylphosphine resin to a 2000ml four-necked flask. , At room temperature 25, add dropwise N,N,N',N'-tetramethylazodicarbonamide (TMAD) 246g for reaction, after the reaction is complete, filter, add 2000ml of water, extract with 1000g of dichloromethane, concentrate the organic Phase, 142.6 g of bisoprolol free base was obtained, the yield was 92%, and the purity was 99.09%.
Reference： [1]Current Patent Assignee: BEIJING JINCHENG TAIER PHARMACEUTICAL; CANGZHOU BRANCH BEIJING JINCHENG TAIER PHARMACEUTI - CN112778142, 2021, A Location in patent: Paragraph 0031; 0038-0043
  • 36
  • 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (2:1) dextro-tartrate salt [ No CAS ]
  • [ 41063-31-4 ]
  • [ 6452-57-9 ]
  • 1-N-Isopropylamino-2-propanon [ No CAS ]
  • [ 16757-32-7 ]
  • [ 32136-81-5 ]
  • C5H13NO2 [ No CAS ]
  • C7H12O2 [ No CAS ]
  • C6H15NO3 [ No CAS ]
  • C10H9NO2 [ No CAS ]
  • C13H17NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1at% Cu-doped TiO2 at 25℃; for 0.583333h; UV-irradiation; 2.4. Photodegradation tests General procedure: The degradation of metoprolol was evaluated by photocatalysis andphoto-Fenton-like processes in a batch reactor with a total volume of 0.1L. The initial metoprolol concentration was 50 mg/L, which correspondsto the actual concentration that may come from some industrial discharges[20]. The catalyst loading was 0.4 g L -1 [21,22] and was keptcompletely dispersed in the photo-reactor by continuous stirring. Thesource of radiation was a UV lamp placed inside the reactor with amonochromatic emission at 254 nm, a power of 8 W and an averageradiation intensity of 166 W m -2. The reactor was a glass cylinder (2.5cm wide) and the lamp was placed at the center. The metoprolol solutionwas maintained at constant temperature (25 °C) by a thermal bath. Theprocedure of a typical experiment was as follows: batch reactor withmetoprolol solution, followed by the addition of photocatalyst andfinally turning on the radiation source (254 nm radiation from a lampplaced at the center of the reactor). For reactions that required hydrogenperoxide, this was incorporated in stoichiometric amount, according tothe reaction of total MET mineralization, just before the lamp wasturned on. All experiments were carried out at natural pH (pH0 ≈ 5.6).
Reference： [1]Avilés-García, Osmín; Espino-Valencia, Jaime; Mendoza-Zepeda, Arisbeht; Donkor, Kingsley; Brewer, Sharon; Romero, Rubi; Natividad, Reyna [Catalysis Today, 2022, vol. 397-399, p. 562 - 573]
  • 37
  • 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (2:1) dextro-tartrate salt [ No CAS ]
  • [ 41063-31-4 ]
  • [ 6452-57-9 ]
  • 1-N-Isopropylamino-2-propanon [ No CAS ]
  • C12H17NO2 [ No CAS ]
  • [ 16757-32-7 ]
  • [ 32136-81-5 ]
  • C5H13NO2 [ No CAS ]
  • C6H11NO3 [ No CAS ]
  • C6H15NO3 [ No CAS ]
  • C10H9NO2 [ No CAS ]
  • C13H17NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1at% Cu-doped TiO2 at 25℃; for 0.583333h; Photolysis; 2.4. Photodegradation tests General procedure: The degradation of metoprolol was evaluated by photocatalysis andphoto-Fenton-like processes in a batch reactor with a total volume of 0.1L. The initial metoprolol concentration was 50 mg/L, which correspondsto the actual concentration that may come from some industrial discharges[20]. The catalyst loading was 0.4 g L -1 [21,22] and was keptcompletely dispersed in the photo-reactor by continuous stirring. Thesource of radiation was a UV lamp placed inside the reactor with amonochromatic emission at 254 nm, a power of 8 W and an averageradiation intensity of 166 W m -2. The reactor was a glass cylinder (2.5cm wide) and the lamp was placed at the center. The metoprolol solutionwas maintained at constant temperature (25 °C) by a thermal bath. Theprocedure of a typical experiment was as follows: batch reactor withmetoprolol solution, followed by the addition of photocatalyst andfinally turning on the radiation source (254 nm radiation from a lampplaced at the center of the reactor). For reactions that required hydrogenperoxide, this was incorporated in stoichiometric amount, according tothe reaction of total MET mineralization, just before the lamp wasturned on. All experiments were carried out at natural pH (pH0 ≈ 5.6).
Reference： [1]Avilés-García, Osmín; Espino-Valencia, Jaime; Mendoza-Zepeda, Arisbeht; Donkor, Kingsley; Brewer, Sharon; Romero, Rubi; Natividad, Reyna [Catalysis Today, 2022, vol. 397-399, p. 562 - 573]

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