Alternatived Products of [ 66373-63-5 ]
Product Details of [ 66373-63-5 ]
| CAS No. : | 66373-63-5 |
MDL No. : | N/A |
| Formula : |
C15H11N3
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
233.27
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 66373-63-5 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 66373-63-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 66373-63-5 ]
- 1
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[ 5805-39-0 ]
-
[ 78-39-7 ]
-
[ 66373-63-5 ]
| Yield | Reaction Conditions | Operation in experiment |
| 92% |
In N,N-dimethyl-formamide at 100℃; for 12h; |
4.1.3. Typical experimental procedure for the synthesis ofbenzimidazoquinazoline. Synthesis of 6a [60]
General procedure: The magnetically stirred mixture of 4a (0.41 g, 2.5 mmol) and triethyl orthoformate (0.3 g, 5 mmol, 2 equiv) in DMF (2.5 mL) was treated at 100 °C (oil bath) for 12 h. The crude reaction mixture was poured into crushed ice (10 g) and the precipitated solid was filtered to obtain 6a as white solid. |
| 89% |
In N,N-dimethyl acetamide for 0.1h; Irradiation; |
|
| 82% |
for 0.1h; Microwave irradiation; Neat (no solvent); |
|
Reference：
[1]Chakraborti, Asit K.; Dhameliya, Tejas M.; Jadhavar, Pradeep S.; Krishna, Vagolu Siva; Patel, Kshitij I.; Saha, Nirjhar; Sriram, Dharmarajan; Vaja, Maulikkumar D.
[Bioorganic Chemistry, 2020, vol. 99]
[2]Khajavi, Mohammad S.; Rad-Moghadam, Kurosh; Hazarkhani, Hasan
[Synthetic Communications, 1999, vol. 29, # 15, p. 2617 - 2624]
[3]Location in patent: experimental part
Davoodnia
[Asian Journal of Chemistry, 2010, vol. 22, # 2, p. 1591 - 1594]
- 2
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[ 93634-54-9 ]
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[ 5805-39-0 ]
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[ 66373-63-5 ]
-
6-(4-methyl-benzylidene)-5,6-dihydro-benzo[4,5]imidazo[1,2-<i>c</i>]quinazoline
[ No CAS ]
- 3
-
[ 13275-42-8 ]
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[ 124-42-5 ]
-
[ 66373-63-5 ]
- 4
-
[ 13275-42-8 ]
-
ethanimidamide hydrochloride
[ No CAS ]
-
[ 66373-63-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With potassium phosphate; copper(l) iodide; In N,N-dimethyl-formamide; at 100℃; for 16h;Inert atmosphere; |
General procedure: 2-(2-Bromophenyl)benzimidazole (2 mmol), guanidine hydrochloride (3 mmol), CuI (5 mol%) and potassium phosphate (6 mmol) were added to DMF in a 50 mL round bottom flask, and refluxed at 100 C for 16 h under nitrogen atmosphere. The reaction was detected by TLC. After the reaction was completed, cooled to room temperature. Then 50 mL of dichloromethane was added and washed by brine. The organic layer was concentrated with evaporator, and the residue was purified by column chromatography on silica gel to give the target compound (A-1 to A-3). |
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