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Chemical Structure| 66376-36-1 Chemical Structure| 66376-36-1

Structure of Alendronic acid
CAS No.: 66376-36-1

Chemical Structure| 66376-36-1

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Alendronate is a bisphosphonate drug used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

Synonyms: Alendronate

4.5 *For Research Use Only !

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Product Details of Alendronic acid

CAS No. :66376-36-1
Formula : C4H13NO7P2
M.W : 249.10
SMILES Code : OC(P(O)(O)=O)(P(O)(O)=O)CCCN
Synonyms :
Alendronate
MDL No. :MFCD00868112

Safety of Alendronic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1759
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human peripheral blood mononuclear cells 10^-10 M 15 days To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-10 M ALN promoted cell proliferation and osteoclast-like cell formation. PMC8035832
Human peripheral blood mononuclear cells 10^-8 M 15 days To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-8 M ALN promoted cell proliferation and osteoclast-like cell formation. PMC8035832
Human peripheral blood mononuclear cells 10^-6 M 15 days To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-6 M ALN was cytotoxic and inhibited cell proliferation. PMC8035832
Rat peripheral blood mononuclear cells 10^-10 M 15 days To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-10 M ALN promoted cell proliferation and osteoclast-like cell formation. PMC8035832
Rat peripheral blood mononuclear cells 10^-8 M 15 days To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-8 M ALN promoted cell proliferation and osteoclast-like cell formation. PMC8035832
Rat peripheral blood mononuclear cells 10^-6 M 15 days To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-6 M ALN was cytotoxic and inhibited cell proliferation. PMC8035832
RAW264.7 cells 0.1 μM, 0.2 μM, 0.4 μM 5 days To evaluate the effect of EA on osteoclast differentiation, results showed that EA concentration-dependently inhibited RANKL-induced osteoclastogenesis. PMC11330075

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar rats Osteoporosis model (bilateral ovariectomy) Oral 3.5 mg/kg Once a week for 6 weeks Evaluate the effect of scaffolds with local ALN release on bone defect healing in osteoporotic and control rats, results showed ALN supported peri-implant bone formation, but systemic ALN administration did not show a positive effect. PMC9901358
Wistar rats Ovariectomy-induced osteoporosis model Oral 2.5 mg/kg Daily administration for 90 days To evaluate the therapeutic effect of ALN on osteoporosis, results showed that ALN significantly alleviated osteoporosis. PMC11330075

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00666627 Post-menopausal Osteoporosis Phase 2 Completed - United Kingdom ... More >> Academic Unit of Bone Metabolism (Sheffield) Sheffield, South Yorkshire, United Kingdom, S5 7AU Less <<
NCT00061256 HIV Infections Phase 2 Completed - -
NCT00051558 Osteoporosis Phase 3 Completed - United States, California ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Loma Linda, California, United States For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Palo Alto, California, United States United States, Colorado For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Aurora, Colorado, United States United States, North Dakota For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Fargo, North Dakota, United States For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Jamestown, North Dakota, United States United States, Wisconsin For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Milwaukee, Wisconsin, United States Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Graz, Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Vienna, Austria Belgium For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Brussels, Belgium For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Gent, Belgium For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Leuven, Belgium Denmark For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Aarhus, Denmark Norway For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Oslo, Norway Puerto Rico For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Carolina, Puerto Rico For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Ponce, Puerto Rico Less <<
NCT00503113 Post-Menopausal Osteoporosis Phase 4 Completed - -
NCT00398606 Osteoporosis, Postmenopausal Phase 3 Completed - -
NCT00503113 - Completed - -
NCT02516111 Chronic Periodontitis Phase 2 Phase 3 Completed - -
NCT00000400 Osteoporosis Phase 2 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT00130403 Osteoporosis, Postmenopausal Phase 4 Completed - United States, New Jersey ... More >> sanofi-aventis, US Bridgewater, New Jersey, United States, 08807 Australia, New South Wales sanofi-aventis, Australia Cove, New South Wales, Australia Belgium sanofi-aventis, Belgium Diegem, Belgium Canada, Quebec sanofi-aventis, Canada Laval, Quebec, Canada France sanofi-aventis, France Paris, France Netherlands sanofi-aventis, Netherlands Gouda, Netherlands United Kingdom sanofi-aventi, UK Guildford, Surrey, United Kingdom Less <<
NCT00000430 Osteopenia Os... More >>teoporosis Less << Phase 3 Terminated - United States, Nebraska ... More >> Creighton University Osteoporosis Research Center Omaha, Nebraska, United States, 68131 Less <<
NCT01648686 Alveolar Bone Healing After De... More >>ntal Extraction Less << Not Applicable Completed - France ... More >> Hotel-Dieu Hospital Nantes, France, 44042 Less <<
NCT03396315 IOP Osteoporo... More >>sis Less << Phase 2 Recruiting January 1, 2024 United States, Nebraska ... More >> Creighton University Not yet recruiting Omaha, Nebraska, United States, 68131 Contact    402-280-4470       Principal Investigator: Robert Recker, MD          Sub-Investigator: Joan Lappe, MD          United States, New York Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Mariana Bucovsky, BA    212-305-7225       Principal Investigator: Elizabeth Shane, MD          Sub-Investigator: Adi Cohen, MD Less <<
NCT00138983 Rheumatoid Arthritis ... More >> Polymyalgia Rheumatica Giant Cell Arteritis Polymyositis Wegener’s Granulomatosis Less << Phase 3 Completed - Netherlands ... More >> UMC Utrecht Utrecht, Netherlands, 3584 CX Less <<
NCT00051558 - Completed - -
NCT00019695 Stage IV Prostate Cancer ... More >> Bone Metastases Adenocarcinoma of the Prostate Recurrent Prostate Cancer Less << Phase 2 Terminated - United States, Maryland ... More >> Medicine Branch Bethesda, Maryland, United States, 20892 Less <<
NCT02609061 Furcation Defects Phase 2 Phase 3 Completed - India ... More >> Government Dental College and Research Institute Bangalore, Karnataka, India, 560002 Less <<
NCT01020253 Bone Density ... More >>Arthroplasty, Replacement, Hip Less << Not Applicable Unknown - Japan ... More >> Department of orthopaedic surgery, Yokohama City University Yokohama, Kanagawa, Japan Less <<
NCT00641771 Osteoporosis Phase 1 Completed - -
NCT00221312 - Completed - United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94143 Less <<
NCT01631214 Postmenopausal Women With Oste... More >>oporosis Less << Phase 3 Completed - -
NCT01588509 Osteoporosis Phase 1 Completed - United States, Arizona ... More >> Research Site Tucson, Arizona, United States, 85711 United States, California Research Site Walnut Creek, California, United States, 94598 United States, Georgia Research Site Gainesville, Georgia, United States, 30501 United States, Hawaii Research Site Honolulu, Hawaii, United States, 96813 United States, Maryland Research Site Bethesda, Maryland, United States, 20817 United States, New Mexico Research Site Albuquerque, New Mexico, United States, 87106 United States, New York Research Site West Haverstraw, New York, United States, 10993 United States, Pennsylvania Research Site Wyomissing, Pennsylvania, United States, 19610 United States, Washington Research Site Seattle, Washington, United States, 98144 Less <<
NCT01128257 - Completed - Germany ... More >> Marburg, Germany, 35043 Less <<
NCT00400530 Osteoporosis Phase 3 Completed - -
NCT00001720 Osteoporosis Phase 2 Completed - United States, Maryland ... More >> National Institute of Child Health and Human Development (NICHD) Bethesda, Maryland, United States, 20892 Less <<
NCT01631214 - Completed - -
NCT01968850 HIV Phase 2 Completed - Canada, Ontario ... More >> St. Michael's Hospital Toronto, Ontario, Canada, M5B 1W8 Toronto General Hospital Toronto, Ontario, Canada, M5G 2N2 Less <<
NCT00001728 Polyostotic Fibrous Dysplasia Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01350934 Osteoporosis, Postmenopausal Phase 4 Completed - -
NCT00005005 Osteoporosis Phase 2 Completed - United States, Maine ... More >> Maine Center for Osteoporosis Bangor, Maine, United States, 04401 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55415 United States, New York Columbia University New York, New York, United States, 10032 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT01350934 - Completed - -
NCT02455869 Chronic Periodontitis Phase 2 Phase 3 Completed - -
NCT00346190 Osteoporosis Phase 3 Unknown April 2007 Canada, Quebec ... More >> Mcgill University Health center Recruiting Montreal, Quebec, Canada, H3A 1A1 Contact: Richard Kremer, MD PhD    514-934-1934 ext 32857       Principal Investigator: Richard Kremer, MD PhD FRCP(c) Less <<
NCT00120757 Osteoporosis ... More >>HIV Infections Less << Phase 3 Completed - France ... More >> Service de Medecine Interne hopital Avicenne Bobigny, France, 93009 cedex Service de Rhumatologie hopital Pitie-Salpetriere Paris, France, 75013 Hôpital Necker service des Maladies Infectieuses Paris, France, 75015 Less <<
NCT00518531 Osteoporosis Phase 3 Completed - -
NCT00330460 Osteoporosis ... More >>Osteopenia Less << Phase 3 Completed - -
NCT00330460 - Completed - -
NCT00293813 Postmenopausal Osteoporosis Phase 2 Completed - -
NCT00293813 - Completed - -
NCT00404820 Osteoporosis Phase 3 Completed - Germany ... More >> For site information contact Novartis Pharmaceuticals Multiple Cities, Germany Less <<
NCT00518531 - Completed - -
NCT00404820 - Completed - -
NCT00092014 Postmenopausal Osteoporosis Phase 3 Completed - -
NCT03623633 Osteoporosis, Postmenopausal ... More >> Osteoporosis Less << Phase 4 Not yet recruiting December 1, 2021 -
NCT00377819 - Completed - -
NCT00377819 Postmenopausal Osteoporosis Phase 3 Completed - -
NCT00122356 Breast Cancer Phase 3 Completed - Australia, New South Wales ... More >> Sydney South West Area Health Service Sydney, New South Wales, Australia, 2050 Tweed Hospital Tweed Heads, New South Wales, Australia, 2485 Australia, Victoria Box Hill Hospital Box Hill, Victoria, Australia, 3128 Maroondah Breast Clinic East Ringwood, Victoria, Australia, 3135 St Vincent's Health Fitzroy, Victoria, Australia, 3065 Barwon Health Geelong, Victoria, Australia, 3220 St John of God Healthcare Geelong, Victoria, Australia, 3220 South West Healthcare Warrnambool, Victoria, Australia, 3280 Less <<
NCT00265252 Non-Traumatic Osteonecrosis Phase 4 Unknown June 2008 Taiwan ... More >> Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung, Taiwan, 807 Less <<
NCT01770106 Rheumatoid Arthritis Phase 4 Completed - Hong Kong ... More >> Prince of Wales Hospital Shatin, N.t., Hong Kong Less <<
NCT01460654 Hypogonadism ... More >>Osteopenia Osteoporosis Less << Phase 2 Suspended June 2019 United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT02518152 Chronic Periodontitis Phase 2 Phase 3 Completed - India ... More >> Government Dental College and Research Institute Bangalore, Karnataka, India, 560002 Less <<
NCT01065779 - Completed - -
NCT00299572 Peritoneal Dialysis Phase 4 Unknown - Taiwan ... More >> Far Eastern Memorial Hospital Not yet recruiting Taipei, Taiwan, 220 Less <<
NCT00391404 Osteoporosis Phase 3 Unknown October 2008 Hong Kong ... More >> Prince of Wales Hospital, Shatin, N.T. Recruiting Hong Kong, Hong Kong Sub-Investigator: Patrick MP Yuen, MD, FRCPC          Sub-Investigator: Chi Kong Li, MBBS, MD          Sub-Investigator: Christopher WK Lam, PhD          Sub-Investigator: Vincent Lee, MBChB Less <<
NCT00277251 Glucocorticoid-Associated Oste... More >>openia and Osteoporosis Less << Phase 2 Phase 3 Completed - -
NCT00729651 Osteoporosis Postmenopausal Phase 4 Completed - -
NCT01065779 - Completed - -
NCT00729651 - Completed - -
NCT00983996 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Insitute Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT00778154 - Completed - United States, California ... More >> Warner Chilcott Research Facility Palm Desert, California, United States, 92269 United States, Colorado Warner Chilcott Research Facility Lakewood, Colorado, United States, 80227 United States, Georgia Warner Chilcott Research Facility Decatur, Georgia, United States, 30033 Warner Chilcott Research Facility Gainesville, Georgia, United States, 30501 United States, Nebraska Warner Chilcott Research Facility Omaha, Nebraska, United States, 68131 United States, Ohio Warner Chilcott Research Facility Cincinnati, Ohio, United States, 45219 United States, Pennsylvania Warner Chilcott Research Facility Wyomissing, Pennsylvania, United States, 19610 Canada, Quebec Warner Chilcott Research Facility Montreal, Quebec, Canada, H2X 1P1 Less <<
NCT02416271 Osteoporosis Phase 4 Completed - -
NCT01552122 Osteoporosis ... More >>Postmenopausal Osteoporosis Less << Phase 3 Withdrawn February 2015 -
NCT01012934 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Insitute Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT00005006 Osteoporosis Phase 2 Completed - United States, New York ... More >> Helen Hayes Hospital, Clinical Research Center West Haverstraw, New York, United States, 10993 Less <<
NCT00327990 Osteoporosis Phase 4 Completed - Netherlands ... More >> GSK Investigational Site Bennebroek, Netherlands, 2121 BB GSK Investigational Site Breda, Netherlands, 4834 AD GSK Investigational Site Damwoude, Netherlands, 9104 GJ GSK Investigational Site Den Haag, Netherlands, 2544 KM GSK Investigational Site Den Haag, Netherlands, 2582 LJ GSK Investigational Site Den Haag, Netherlands, 2584 HV GSK Investigational Site Driebergen-rijsenburg, Netherlands, 3972 WG GSK Investigational Site Easterein, Netherlands, 8734 CG GSK Investigational Site Eersel, Netherlands, 5521 CD GSK Investigational Site Eindhoven, Netherlands, 5613 BE GSK Investigational Site Enschede, Netherlands, 7544 NZ GSK Investigational Site Etten-leur, Netherlands, 4872 LA GSK Investigational Site Geleen, Netherlands, 6163 GC GSK Investigational Site Groesbeek, Netherlands, 6561 CM GSK Investigational Site Heerlen, Netherlands, 6417 BR GSK Investigational Site Hengelo, Netherlands, 7255 AM GSK Investigational Site Hoogvliet, Netherlands, 3192 JN GSK Investigational Site Hoogwoud, Netherlands, 1718 BG GSK Investigational Site Hulst, Netherlands, 4561 CJ GSK Investigational Site Landgraaf, Netherlands, 6373 JS GSK Investigational Site Losser, Netherlands, 7581 BV GSK Investigational Site Midwoud, Netherlands, 1679 GJ GSK Investigational Site Nijverdal, Netherlands, 7442 LS GSK Investigational Site Nunspeet, Netherlands, 8071 LX GSK Investigational Site Oldebroek, Netherlands, 8096 AV GSK Investigational Site Oudenbosch, Netherlands, 4731 MA GSK Investigational Site Poortvliet, Netherlands, 4693 BT GSK Investigational Site Prinsenbeek, Netherlands, 4841 RR GSK Investigational Site Raalte, Netherlands, 8101 ZW GSK Investigational Site Ridderkerk, Netherlands, 2985 VG GSK Investigational Site Rotterdam, Netherlands, 3082 DC GSK Investigational Site Spijkenisse, Netherlands, 3207 NB GSK Investigational Site Tilburg, Netherlands, 5038 DE GSK Investigational Site Voerendaal, Netherlands, 6367 ED GSK Investigational Site Wassenaar, Netherlands, 2241 KE GSK Investigational Site Wildervank, Netherlands, 9648 BE GSK Investigational Site Woerden, Netherlands, 3443 GG GSK Investigational Site Zaandam, Netherlands, 1504 JA Less <<
NCT00580047 Renal Insufficiency Not Applicable Completed - United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less <<
NCT00739466 Coronary Artery Stenosis Phase 2 Completed - Israel ... More >> Hillel Yaffe Medical Center Hadera, Israel, 38100 Bnei Zion Medical Center Haifa, Israel, 31048 Rambam Health Care Campus Haifa, Israel, 31096 Lady Davis Carmel Medical Center Haifa, Israel, 34362 Shaare Zedek Medical Center Jerusalem, Israel, 91031 Meir Medical Center Kfar Saba, Israel, 44281 Western Galilee Hospital, Nahariya Nahariya, Israel, 22100 Rabin Medical Center Petah Tikva, Israel, 49100 The Baruch Padeh Medical Center, Poriya Poriya, Israel, 15218 Sheba Medical Center, Tel Hashomer Ramat Gan, Israel, 52521 Kaplan Medical Center Rehovot, Israel, 76100 The Tel Aviv Sourasky Medical Center Tel Aviv, Israel, 64239 Less <<
NCT03204097 Chronic Periodontitis Phase 2 Phase 3 Completed - -
NCT03197623 Osteopenia Os... More >>teoporosis Osteonecrosis Less << Phase 1 Recruiting June 2020 United States, California ... More >> West Coast Clinical Trials (WCCT) Recruiting Cypress, California, United States, 92626 Contact: Kacie Hale, BS    714-252-0700    kacie.hale@wcct.com    Principal Investigator: Bonnie Bock, MD          Diablo Clinical Research Recruiting Walnut Creek, California, United States, 94598 Contact: Lana Norman    925-930-7267    lnorman@Diabloclinical.com    Contact: Ava Paulazzo    (925) 930-7267    apaulazzo@Diabloclinical.com    Principal Investigator: Mark Christiansen, MD          United States, Pennsylvania Altoona Center for Clinical Research Recruiting Duncansville, Pennsylvania, United States, 16635 Contact: Lisa Claycomb    814-696-7053    altoonaresearch@gmail.com    Principal Investigator: Alan Kivitz, MD          United States, Texas Metroplex Clinical Research Center Recruiting Dallas, Texas, United States, 75231 Contact: Michael Johnson    214-879-6737    mjohnson@mcrcdallas.com    Principal Investigator: Roy Fleischmann, MD Less <<
NCT00463268 Osteopenia Phase 3 Completed - Belgium ... More >> University (UCL) Louvain Hospital in Mont-Godinne Yvoir, Namur, Belgium, 5530 Less <<
NCT00261625 End-Stage Renal Disease ... More >> Osteoporosis Less << Phase 4 Completed - -
NCT01512446 Osteoporosis Phase 3 Terminated(low recruitment rat... More >>e) Less << - Germany ... More >> Department of Internal Medicine III, Alfried Krupp Krankenhaus Essen Steele Essen, Germany, 45276 Less <<
NCT00580047 - Completed - -
NCT02598440 Postmenopausal Osteoporosis Phase 4 Completed - -
NCT00806416 Osteoporosis Phase 1 Completed - -
NCT00236002 Osteoporosis Phase 3 Terminated(Slow accrual than a... More >>nticipated.) Less << - -
NCT00713258 Back Pain Phase 4 Terminated(Slow enrolment) - Denmark ... More >> Nycomed Roskilde, Denmark, 4000 Less <<
NCT01889134 Primary Hyperparathyroidism Not Applicable Completed - Poland ... More >> Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University Wroclaw, Poland, 50-367 Less <<
NCT01437111 Osteoporosis Phase 3 Completed - -
NCT01812551 Osteoporosis ... More >>Cystic Fibrosis Less << Phase 3 Completed - Holy See (Vatican City State) ... More >> CRR Fibrosi Cistica, Divisione Gastroenterologia, Ospedale Bambin Gesù Città del Vaticano, Holy See (Vatican City State) Italy CRR Fibrosi Cistica, Unità Operativa di Pediatria, Ospedale Misericordia Grosseto, Italy CRR Fibrosi Cistica, Clinica Pediatrica, Policlinico Universitario di Messina Messina, Italy Istituto Auxologico Italiano IRCCS Milano, Italy, 20145 Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano Milano, Italy CRR Fibrosi Cistica, Dipartimento Pediatria, Università Federico II Napoli, Italy CRR Fibrosi Cistica Adulti, Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano, Italy CRR Fibrosi Cistica, Ospedale dei Bambini, ARNAS Civico Palermo, Italy CRR Fibrosi Cistica, Dipartimento di Pediatria, Policlinico Umberto I Roma, Italy CRR Fibrosi Cistica, Divisione di Pediatria, Istituto Burlo Garofolo Trieste, Italy CRR Fibrosi Cistica, Azienda Ospedalierouniversitaria di Verona Verona, Italy Less <<
NCT00395382 Vascular Calcification ... More >> Arteriosclerosis Less << Phase 4 Completed - Australia, Victoria ... More >> Department of Nephrology, Monash Medical Centre Clayton, Victoria, Australia, 3168 Less <<
NCT00010439 - Completed - -
NCT00806416 - Completed - -
NCT00010439 Osteoporosis Phase 2 Completed - United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT00713258 - Terminated(Slow enrolment) - -
NCT00297830 Heart Transplantation ... More >> Liver Transplantation Bone Resorption Less << Phase 2 Phase 3 Completed - United States, New York ... More >> Columbia University Medical Center New York, New York, United States, 10032 Less <<
NCT00835406 - Completed - -
NCT01131884 - Terminated(Only 1 participant ... More >>enrolled since the beginning of this study) Less << - -
NCT01437111 - Completed - -
NCT01131884 Spinal Cord Injury ... More >> Osteoporosis Less << Not Applicable Terminated(Only 1 participant ... More >>enrolled since the beginning of this study) Less << - United States, New York ... More >> University of Rochester Physical Medicine and Rehabilitation Rochester, New York, United States, 14642 University of Rochester Rochester, New York, United States, 14642 Less <<
NCT00835406 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Less <<
NCT02795546 Intrabony Periodontal Defect Phase 4 Completed - -
NCT00803790 Osteoporosis Phase 1 Completed - -
NCT00297830 - Completed - -
NCT02230332 Asthma Phase 2 Phase 3 Completed - United States, Arizona ... More >> University of Arizona College of Medicine Tucson, Arizona, United States, 85724 United States, California University of California - San Francisco San Francisco, California, United States, 94143 United States, Colorado National Jewish Health Denver, Colorado, United States, 80206 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 University of Illinois at Chicago Chicago, Illinois, United States, 60612 University of Chicago Chicago, Illinois, United States, 60637 United States, Massachusetts Brigham & Women's Hospital Boston, Massachusetts, United States, 02115 United States, Missouri Washington University Saint Louis, Missouri, United States, 63110 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53972 Less <<
NCT02230332 - Completed - -
NCT02944799 Rheumatoid Arthritis ... More >> Osteoporosis Less << Phase 2 Recruiting July 2021 Denmark ... More >> Aalborg University Hospital Recruiting Aalborg, Denmark, 9000 Principal Investigator: Salome Kristensen, PhD          Aarhus University Hospital Recruiting Aarhus, Denmark, 8000 Sub-Investigator: Anne-Birgitte Blavnsfeldt, MD          Hjørring Hospital Not yet recruiting Hjørring, Denmark, 9800 Principal Investigator: Norah Thomsen, MD          Odense University Hospital Recruiting Odense, Denmark, 5000 Principal Investigator: Hanne Lindegaard, PhD          Silkeborg Regional Hospital Active, not recruiting Silkeborg, Denmark, 8600 Vejle Hospital Active, not recruiting Vejle, Denmark, 7100 Less <<
NCT00577850 Osteopenia Os... More >>teoporosis Less << Phase 1 Completed - United States, Florida ... More >> Research Facility Gainesville, Florida, United States United States, Louisiana Research Site New Orleans, Louisiana, United States Less <<
NCT00921557 HIV Infection Phase 2 Completed - United States, California ... More >> David Geffen School of Medicine at UCLA NICHD CRS Los Angeles, California, United States, 90095-1752 United States, Florida Pediatric Perinatal HIV Clinical Trials Unit CRS Miami, Florida, United States, 33136 USF - Tampa NICHD CRS Tampa, Florida, United States, 33606 United States, Illinois Lurie Children's Hospital of Chicago (LCH) CRS Chicago, Illinois, United States, 60614-3393 United States, Maryland Johns Hopkins Univ. Baltimore NICHD CRS Baltimore, Maryland, United States, 21287 United States, Massachusetts WNE Maternal Pediatric Adolescent AIDS CRS Worcester, Massachusetts, United States, 01605 United States, Tennessee St. Jude Children's Research Hospital CRS Memphis, Tennessee, United States, 38105 Brazil SOM Federal University Minas Gerais Brazil NICHD CRS Belo Horizonte, Minas Gerais, Brazil, 30130-100 Univ. of Sao Paulo Brazil NICHD CRS Sao Paulo, Brazil, 14049-900 Puerto Rico San Juan City Hosp. PR NICHD CRS San Juan, Puerto Rico, 00936 Less <<
NCT00803790 - Completed - -
NCT02303873 Osteogenesis Imperfecta Phase 4 Completed - -
NCT00259857 Osteoporosis Phase 2 Completed - United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT02057263 Hepatitis B Phase 1 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT00157690 Cystic Fibrosis ... More >> Osteoporosis Bone Diseases, Metabolic Less << Phase 4 Completed - Canada, Alberta ... More >> Dr. Harvey Rabin - Health Sciences Centre Calgary, Alberta, Canada, T2N 4N1 Canada, Ontario McMaster University Hamilton, Ontario, Canada London Health Sciences Centre London, Ontario, Canada, N6A 4G5 Canada, Quebec Centre de Recherche - CHUM Montreal, Quebec, Canada, H2W 1T7 Montreal Chest Institute Montreal, Quebec, Canada, H2X 2P4 CHUL Hospital Sainte-Foy, Quebec, Canada, G1V 4G2 Less <<
NCT00936260 Osteoporosis Not Applicable Completed - Spain ... More >> University San Carlos Hospital Madrid, Spain, 28040 Less <<
NCT00921557 - Completed - -
NCT02195895 Spinal Cord Injury ... More >> Bone Loss Osteoporosis Less << Phase 2 Completed - United States, Illinois ... More >> Northwestern University Feinberg School of Medicine Chicago, Illinois, United States, 60611 Less <<
NCT00504166 Osteopenia Os... More >>teoporosis Less << Phase 4 Completed - United States, California ... More >> University of California Department of Radiology San Francisco, California, United States, 94107 Less <<
NCT00504166 - Completed - -
NCT00460057 Osteoporosis Phase 4 Completed - -
NCT02322099 Bone Demineralization Phase 4 Unknown October 2018 Ireland ... More >> Mater Misericordiae University Hospital Recruiting Dublin, Ireland, 7 Contact: Tara McGinty, MB, BCh, BAO       tara.mcginty@ucd.ie    Contact: Patrick WG Mallon, MB BCh, PhD, FRCPI       paddy.mallon@ucd.ie    Sub-Investigator: John Lambert, MD, PhD          Sub-Investigator: Gerard Sheehan, MB BCh BAO, FRCPI          Beaumont Hospital Recruiting Dublin, Ireland, 9 Contact: Samuel McConkey, MB BCh, MD,MRCPI       smcconkey@rcsi.ie    Contact: Nora McNally, MD Less <<
NCT03005678 Osteoporosis Phase 4 Recruiting February 2020 China ... More >> Department of Medicine, Tuen Mun Hospital Recruiting Hong Kong, China, 000 Contact: Chi Chiu Mok, MD, FRCP    (852) 2468 5386    ccmok2006@gmail.com    Principal Investigator: Chi Chiu Mok, MD, FRCP Less <<
NCT00259857 - Completed - -
NCT01104987 - Completed - Sweden ... More >> Department of Rheumatology, Sahlgrenska University Hospital Gothenburg, Sweden, S-413 45 Less <<
NCT02470611 Periodontitis ... More >> Bone Resorption Less << Phase 4 Completed - Brazil ... More >> Dental clinic of pontifical catholic university Belo Horizonte, Minas Gerais, Brazil Less <<
NCT02195895 - Completed - -
NCT02168543 Chronic Periodontitis Phase 2 Completed - -
NCT02781805 Breast Neoplasms Phase 1 Recruiting August 1, 2019 United States, Wisconsin ... More >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53705 Contact: Cancer Connect    800-622-8922    cancerconnect@uwcarbone.wisc.edu    Principal Investigator: Lee Wilke Less <<
NCT00920075 - Completed - United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT03435094 - Not yet recruiting August 1, 2019 Switzerland ... More >> Endokrinologische Praxis & Labor Not yet recruiting Basel, BS, Switzerland, 4055 Contact: Christian Meier, Prof          Hôpital Universitaire de Genève, Service des maladies osseuses Not yet recruiting Genève, GE, Switzerland, 1211 Contact: Serge Ferrari, Prof Less <<
NCT01133496 Healthy Phase 1 Completed - India ... More >> GVK Biosciences Pvt. Ltd., Hyderabad, Andhra Pradesh, India, 500038 Less <<
NCT02461667 Chronic Periodontitis Phase 2 Phase 3 Completed - -
NCT02371252 Osteoporosis Phase 4 Unknown October 2017 Thailand ... More >> Siriraj Hospital Recruiting Bangkok Noi, Bangkok, Thailand, 10700 Contact: Aasis Unnanuntana, MD    +66-2419-7968    uaasis@gmail.com    Contact: Atthakorn Jarusriwanna, MD    +66-2419-7968    wonton2ton@hotmail.com Less <<
NCT03542695 Breast Carcinoma ... More >> Calcification Less << Early Phase 1 Not yet recruiting December 7, 2020 United States, California ... More >> City of Hope Medical Center Not yet recruiting Duarte, California, United States, 91010 Contact: Veronica C. Jones, MD    626-471-7100    vjones@coh.org    Principal Investigator: Veronica C. Jones, MD Less <<
NCT00359385 Hyperparathyroidism Phase 4 Withdrawn(incomplete enrollmen... More >>t) Less << - United States, New York ... More >> CUMC New York, New York, United States, 10032 Less <<
NCT03051620 - Active, not recruiting July 1, 2019 Denmark ... More >> Department of Endocrinology and Internal Medicine, Aarhus University Hospital Aarhus, Denmark, 8000 Less <<
NCT00920075 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.07mL

4.01mL

2.01mL

40.14mL

8.03mL

4.01mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

Historical Records

Categories