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Chemical Structure| 664993-53-7 Chemical Structure| 664993-53-7

Structure of JW 55
CAS No.: 664993-53-7

Chemical Structure| 664993-53-7

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JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively.

Synonyms: Tankyrase 1/2 Inhibitor IV

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Product Details of JW 55

CAS No. :664993-53-7
Formula : C25H26N2O5
M.W : 434.48
SMILES Code : O=C(C1=CC=CO1)NC2=CC=C(C(NCC3(C4=CC=C(OC)C=C4)CCOCC3)=O)C=C2
Synonyms :
Tankyrase 1/2 Inhibitor IV
MDL No. :MFCD03863265
InChI Key :ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Pubchem ID :2946601

Safety of JW 55

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of JW 55

epigenetics
DNA

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.51mL

2.30mL

1.15mL

23.02mL

4.60mL

2.30mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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