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Chemical Structure| 666842-36-0 Chemical Structure| 666842-36-0

Structure of KGA-2727
CAS No.: 666842-36-0

Chemical Structure| 666842-36-0

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KGA-2727 is a highly selective and orally active SGLT1 inhibitor with significant high affinity. Its selectivity for SGLT1 is much higher than that for SGLT2, showing significant effects in anti-diabetes treatment.

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Product Details of KGA-2727

CAS No. :666842-36-0
Formula : C26H40N4O8
M.W : 536.62
SMILES Code : O=C(N)CCNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(C)=C1
MDL No. :MFCD32701917

Safety of KGA-2727

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
KGA-2727 stands as the first selective, potent, and orally active inhibitor of SGLT1, with Ki values of 97.4 nM for humans and 43.5 nM for rats. Its selectivity ratios (Ki for SGLT2/Ki for SGLT1) reach 140 for humans and 390 for rats, showcasing antidiabetic effectiveness[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.32mL

1.86mL

0.93mL

18.64mL

3.73mL

1.86mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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