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[ CAS No. 66990-30-5 ] {[proInfo.proName]}

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Chemical Structure| 66990-30-5
Chemical Structure| 66990-30-5
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Product Details of [ 66990-30-5 ]

CAS No. :66990-30-5 MDL No. :MFCD00041683
Formula : C23H38O2 Boiling Point : -
Linear Structure Formula :- InChI Key :DIEDVCMBPCRJFQ-UHFFFAOYSA-N
M.W : 346.55 Pubchem ID :538457
Synonyms :

Safety of [ 66990-30-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 66990-30-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66990-30-5 ]

[ 66990-30-5 ] Synthesis Path-Downstream   1~49

  • 1
  • [ 2777-65-3 ]
  • [ 60705-20-6 ]
  • [ 66990-30-5 ]
YieldReaction ConditionsOperation in experiment
(i) aq. NH2OH*HCl, CuCl2, EtNH2, KOH, (ii) /BRN= 1758339/, MeOH; Multistep reaction;
  • 2
  • [ 2777-65-3 ]
  • [ 118869-25-3 ]
  • [ 66990-30-5 ]
YieldReaction ConditionsOperation in experiment
48% With potassium hydroxide; methylamine; copper(l) chloride In tetrahydrofuran; methanol; water 1) 20 deg C, 4 h, 2) 40 deg C, 1 h;
  • 4
  • [ 67-56-1 ]
  • [ 56119-82-5 ]
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid (S)-3-(ethoxy-methoxy-phosphoryl)-1-tricosa-10,12-diynoyloxymethyl-propyl ester [ No CAS ]
  • Tricosa-10,12-diynoic acid (S)-3-(diethoxy-phosphoryl)-1-tricosa-10,12-diynoyloxymethyl-propyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide 2.) CH2Cl2, RT, 14 h; Multistep reaction. Title compound not separated from byproducts;
  • 5
  • [ 56119-82-5 ]
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid (S)-3-phosphono-1-tricosa-10,12-diynoyloxymethyl-propyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With methanol; dmap; trimethylsilyl bromide; water; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide Multistep reaction;
  • 6
  • [ 56119-82-5 ]
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid (S)-3-(ethoxy-methoxy-phosphoryl)-1-tricosa-10,12-diynoyloxymethyl-propyl ester [ No CAS ]
  • Tricosa-10,12-diynoic acid (S)-3-(diethoxy-phosphoryl)-1-tricosa-10,12-diynoyloxymethyl-propyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With methanol; dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide 2.) CH2Cl2, RT, 14 h; Multistep reaction. Title compound not separated from byproducts;
  • 7
  • [ 6066-82-6 ]
  • [ 66990-30-5 ]
  • 2,5-dioxopyrrolidin-1-yl tricosa-10,12-diynoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
98% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; Darkness;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane
  • 8
  • [ 66990-30-5 ]
  • [ 20439-47-8 ]
  • Tricosa-10,12-diynoic acid ((1R,2R)-2-tricosa-10,12-diynoylamino-cyclohexyl)-amide [ No CAS ]
YieldReaction ConditionsOperation in experiment
49.7% With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane
  • 9
  • [ 66990-30-5 ]
  • [ 160539-04-8 ]
  • [N5'-(2',2''-bipyridyl)]-10,12-tricosadiyne-1-amide [ No CAS ]
  • 10
  • [ 64-17-5 ]
  • [ 66990-30-5 ]
  • ethyl tricosa-10,12-diynoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With sulfuric acid for 5h; Heating;
  • 11
  • [ 66990-30-5 ]
  • [ 23737-49-7 ]
  • [ 406207-29-2 ]
YieldReaction ConditionsOperation in experiment
70.4% With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;
  • 12
  • [ 66990-30-5 ]
  • poly(10,12-tricosadiynoic acid), chiral [ No CAS ]
YieldReaction ConditionsOperation in experiment
UV-irradiation; circularly polarized light;
  • 13
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid (2R,4aR,6S,7R,8R,8aR)-7-hydroxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl chloride / CH2Cl2 / 20 °C 2: 11 percent / pyridine / CH2Cl2 / 24 h / 20 °C
  • 14
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid (2R,4aR,6S,7R,8S,8aS)-8-hydroxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl chloride / CH2Cl2 / 20 °C 2: 56 percent / pyridine / CH2Cl2 / 24 h / 20 °C
  • 15
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid (2R,4aR,6S,7R,8S,8aR)-6-methoxy-2-phenyl-7-tricosa-10,12-diynoyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl chloride / CH2Cl2 / 20 °C 2: 4 percent / pyridine / CH2Cl2 / 24 h / 20 °C
  • 16
  • [ 66990-30-5 ]
  • 6-(docosa-9,11-diynyl)-2,4-diamino-1,3,5-triazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 81 percent / H2SO4 / 5 h / Heating 2: 59 percent / methanol / 20 h / 40 °C
  • 17
  • [ 66990-30-5 ]
  • 10,12-tricosadiynohydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2 2: hydrazine hydrate / CH2Cl2
  • 18
  • [ 66990-30-5 ]
  • 1-((S)-3,4-bis(10,12-tricosadiynoyloxy)butyl)phosphonic acid 2-(N,N,N-trimethylammonium)ethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1.) aq. p-TsOH, MeOH, 2.) DMAP, DCC, 3.) TMSBr, 4.) H2O 2: pyridine / various solvent(s) / 20 h / 60 °C
  • 19
  • [ 66990-30-5 ]
  • Tricosa-10,12-diynoic acid pyridin-2-ylamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: SOCl2, DMF / pentane / Heating 2: benzene / 1) 20 deg C, 3 h, 2) 60 deg C, 1 h
  • 20
  • [ 79-37-8 ]
  • [ 112-60-7 ]
  • [ 66990-30-5 ]
  • [ 145703-53-3 ]
YieldReaction ConditionsOperation in experiment
1.50 g (41%) With pyridine In tetrahydrofuran 11 Tetraethylene glycol mono- 10,12-tricosadiynoate EXAMPLE 11 Tetraethylene glycol mono- 10,12-tricosadiynoate 10,12-Tricosadiynoic acid (2.50 g, 0.007 mol) in tetrahydrofuran (30 ml) was reacted with oxalyl chloride (2.25 g, 0.017 mol) to obtain the corresponding acid chloride. This acid chloride (2.45 g, 0.007 mol) dissolved in anhydrous tetrahydrofuran (10 ml) was added dropwise to a mixture of tetraethylene glycol (1.32 g, 0.007 mol) and anhydrous pyridine (0.83 g, 0.01 mol) in anhydrous tetrahydrofuran (40 ml). The mixture was stirred overnight at room temperature. The precipitated pyridinium salt was filtered off and the solvent removed under vacuum. The resulting liquid was purified by flash chromatography (silica gel/ethyl acetate) to give 1.50 g (41%) of the title compound as a colour less oil. 1 H NMR (60 MHz, CDCl3): δ 0.88 (m, 3H, CH3 CH2), 1.30 (m, 28H, CH2), 2.20 (m, 6H, CH2), 3.65 (s, 11H, 7*CH2 O), 4.20 (m, 2H, CH2 CO).
1.50 g (41%) With pyridine In tetrahydrofuran 11 Tetraethylene glycol mono-10,12-tricosadiynoate EXAMPLE 11 Tetraethylene glycol mono-10,12-tricosadiynoate 10,12-Tricosadiynoic acid (2.50 g, 0.007 mol) in tetrahydrofuran (30 ml) was reacted with oxalyl chloride (2.25 g, 0.017 mol) to obtain the corresponding acid chloride. This acid chloride (2.45 g, 0.007 mol) dissolved in anhydrous tetrahydrofuran (10 ml) was added dropwise to a mixture of tetraethylene glycol (1.32 g, 0.007 mol) and anhydrous pyridine (0.83 g, 0.01 mol) in anhydrous tetrahydrofuran (40 ml). The mixture was stirred overnight at room temperature. The precipitated pyridinium salt was filtered off and the solvent removed under vacuum. The resulting liquid was purified by flash chromatography (silica gel/ethyl acetate) to give 1.50 g (41%) of the title compound as a colourless oil. 1 H NMR (60 MHz, CDCl3): δ0.88 (m, 3H, CH3 CH2), 1.30 (m, 28H, CH2), 2.20 (m, 6H, CH2), 3.65 (s, 14H, 7*CH2 O), 4.20 (m, 2H, CH2 CO).
  • 21
  • [ 66990-30-5 ]
  • [ 145609-79-6 ]
YieldReaction ConditionsOperation in experiment
2.68 g (74%) With sulfuric acid In methanol 13.a a a Methyl 10,12-tricosadiynoate 10,12- Tricosadiynoic acid (3.0 g, 0.0084 mol), methanol (15 ml) and concentrated sulfuric acid (0.8 ml) were heated to reflux and stirred for 1 hour. The cooled mixture was taken up in either (40 ml) and washed with 10% NaHCO3 (20 ml) and water (20 ml), and the organic phase was dried (MgSO4). Evaporation of the solvent gave 2.68 g (74%) of the title compound. 1 H NMR (60 MHz, CDCl3): δ 0.98 (m, 3H, CH3 CH2), 1.28 (m, 28H, CH2), 2.25 (m, 6H, CH2), 3.70 (s, 3H, CH2 O).
2.68 g (74%) With sulfuric acid In methanol 13.a a a Methyl 10,12-tricosadiynoate 10,12-Tricosadiynoic acid (3.0 g, 0.0084 mol), methanol (15 ml) and concentrated sulfuric acid (0.8 ml) were heated to reflux and stirred for 1 hour. The cooled mixture was taken up in ether (40 ml) and washed with 10% NaHCO3 (20 ml) and water (20 ml), and the organic phase was dried (MgSO4). Evaporation of the solvent gave 2.68 g (74%) of the title compound. 1 H NMR (60 MHz, CDCl3): δ0.98 (m, 3H, CH3 CH2), 1.28 (m, 28H, CH2), 2.25 (m, 6H, CH2), 3.70 (s, 3H, CH3 O).
YieldReaction ConditionsOperation in experiment
2 (2) (2) Tricosa-10,12-diynoic acid 10-Undecynoic acid (21.8 g, 0.120 mol) was neutralized with a solution of 57 mL 10 percent KOH in water and hydroxylamine hydrochloride (0.380 g) was added. Then a catalyst consisting of a solution of 1.9 g cuprous chloride in 16 g 70 percent aqueous ethylamine was added. A yellow precipitate formed immediately.
  • 23
  • [ 66990-30-5 ]
  • polymer, polymerisation with left-handed circularly polarized UV light; monomer(s): 10,12-tricosadiynoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
UV-irradiation;
  • 24
  • [ 66990-30-5 ]
  • polymer, polymerisation with right-handed circularly polarized UV light; monomer(s): 10,12-tricosadiynoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
UV-irradiation;
  • 25
  • [ 66990-30-5 ]
  • Polymer; Monomer(s): 10,12-tricosadiynoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
for 0.166667h; UV-irradiation;
  • 26
  • [ 66990-30-5 ]
  • poly(10,12-tricosadiynoic acid); monomer(s): 10,12-tricosadiynoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
In various solvent(s) at 10℃;
  • 27
  • [ 66990-30-5 ]
  • [ 1093785-54-6 ]
  • [ 1187652-24-9 ]
YieldReaction ConditionsOperation in experiment
57.8% Stage #1: tricosa-10,12-diynoic acid With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1h; Inert atmosphere; Cooling with ice; Stage #2: hexa-tert-butyl 10,10'-(6-((2-aminoethyl)amino)-1,3,5-triazine-2,4-diyl)bis(1,4,7,10-tetraazacyclo-dodecane-1,4,7-tricarboxylate) In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Cooling with ice;
  • 28
  • [ 4117-33-3 ]
  • [ 66990-30-5 ]
  • [ 1229722-32-0 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h;
  • 29
  • [ 66990-30-5 ]
  • [ 51094-17-8 ]
  • C136H174N4O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With dmap; dicyclohexyl-carbodiimide In dichloromethane at -10 - 20℃;
  • 30
  • [ 66990-30-5 ]
  • [ 1310799-65-5 ]
  • [ 71989-26-9 ]
  • C69H110N12O9*4ClH [ No CAS ]
YieldReaction ConditionsOperation in experiment
38.9% Stage #1: Fmoc-Lys(tert-butoxycarbonyl) In dichloromethane; N,N-dimethyl-formamide at 45 - 55℃; for 0.333333h; Microwave irradiation; solid phase reaction; Stage #2: With piperidine In dichloromethane; N,N-dimethyl-formamide at 45 - 55℃; for 0.0833333h; Microwave irradiation; solid phase reaction; Stage #3: tricosa-10,12-diynoic acid; N-α-Fmoc-(4-morpholine-1,8-naphthalimido)-Lysine Further stages;
  • 31
  • [ 66990-30-5 ]
  • Nα-(Fluoren-9-ylmethoxycarbonyl)-N(im)-(tert-butyloxycarbonyl)-L-histidine [ No CAS ]
  • C29H46N4O2*ClH [ No CAS ]
YieldReaction ConditionsOperation in experiment
58.2% Stage #1: Nα-(Fluoren-9-ylmethoxycarbonyl)-N(im)-(tert-butyloxycarbonyl)-L-histidine In dichloromethane; N,N-dimethyl-formamide at 45 - 55℃; for 0.333333h; Microwave irradiation; solid phase reaction; Stage #2: With piperidine In dichloromethane; N,N-dimethyl-formamide at 45 - 55℃; for 0.0833333h; Microwave irradiation; solid phase reaction; Stage #3: tricosa-10,12-diynoic acid Further stages;
  • 32
  • [ 66990-30-5 ]
  • [ 1351161-74-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: thionyl chloride / dichloromethane / 16 h / 20 - 25 °C / Inert atmosphere 1.2: 24.5 h / 20 °C / Inert atmosphere 2.1: N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere 2.2: 6 h / 50 °C / Inert atmosphere
  • 33
  • [ 66990-30-5 ]
  • [ 107-15-3 ]
  • [ 113377-10-9 ]
YieldReaction ConditionsOperation in experiment
76% Stage #1: tricosa-10,12-diynoic acid With thionyl chloride In dichloromethane at 20 - 25℃; for 16h; Inert atmosphere; Stage #2: ethylenediamine In dichloromethane at 20℃; for 24.5h; Inert atmosphere;
Stage #1: tricosa-10,12-diynoic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Stage #2: ethylenediamine In dichloromethane for 1h;
  • 34
  • [ 66990-30-5 ]
  • [ 1332704-95-6 ]
  • [ 1535665-82-7 ]
YieldReaction ConditionsOperation in experiment
78% With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 96h; Inert atmosphere; Darkness;
  • 35
  • [ 66990-30-5 ]
  • C37H55NO6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h 2: pyridine / dichloromethane / 5 h / 0 - 20 °C / Darkness; Inert atmosphere
  • 36
  • [ 66990-30-5 ]
  • C23H37NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
With diphenyl phosphoryl azide; triethylamine In tetrahydrofuran at 60℃; for 2h; Darkness;
  • 37
  • [ 66990-30-5 ]
  • C37H56N2O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: diphenyl phosphoryl azide; triethylamine / tetrahydrofuran / 2 h / 60 °C / Darkness 2: tetrahydrofuran / 6 h / 20 °C / Darkness
  • 38
  • [ 67-56-1 ]
  • [ 66990-30-5 ]
  • [ 145609-79-6 ]
YieldReaction ConditionsOperation in experiment
1.56 g With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃;
  • 39
  • [ 109-86-4 ]
  • [ 66990-30-5 ]
  • 2-methoxyethyl tricosa-10,12-diynoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃;
  • 40
  • [ 66990-30-5 ]
  • 1,1,1,3,3,3-hexafluoropropan-2-yl tricosa-10,12-diynoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: triethylamine / dichloromethane / 20 °C
  • 41
  • [ 66990-30-5 ]
  • 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl tricosa-10,12-diynoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: triethylamine / dichloromethane / 20 °C
  • 42
  • [ 66990-30-5 ]
  • (3-(tricosa-10,12-diynoyloxy)phenyl)boronic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: triethylamine / dichloromethane; tetrahydrofuran / 18 h / 20 °C
  • 43
  • [ 66990-30-5 ]
  • N,N,N-trimethyl-2-(tricosa-10,12-diynamido)ethan-1-aminium iodide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere; Darkness 2: dichloromethane / 24 h / 20 °C 3: potassium carbonate / acetonitrile / 24 h / 20 °C
  • 44
  • [ 66990-30-5 ]
  • N-(2-(dimethylamino)ethyl)tricosa-10,12-diynamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere; Darkness 2: dichloromethane / 24 h / 20 °C
  • 45
  • [ 66990-30-5 ]
  • methyl tricosa-10,12-diynoylphenylalaninate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere; Darkness 2: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere; Darkness
  • 46
  • [ 66990-30-5 ]
  • methyl tricosa-10,12-diynoylleucinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere; Darkness 2: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere; Darkness
  • 47
  • [ 66990-30-5 ]
  • 2,2,2-trifluoroethyl tricosa-10,12-diynoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: triethylamine / dichloromethane / 6 h / 20 °C
  • 48
  • [ 66990-30-5 ]
  • 10,12-tricosadiyn-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: tricosa-10,12-diynoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; Inert atmosphere; Stage #2: With ammonium hydroxide In tetrahydrofuran Inert atmosphere; Cooling with ice; Stage #3: With lithium aluminium tetrahydride In diethyl ether Inert atmosphere; Cooling with ice;
  • 49
  • [ 2777-65-3 ]
  • [ 66990-30-5 ]
YieldReaction ConditionsOperation in experiment
30% With copper(l) iodide; hydroxylamine hydrochloride; ethylamine; potassium hydroxide In tetrahydrofuran; methanol; water at 0 - 20℃; for 24h;
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