Home Cart 0 Sign in  
X

[ CAS No. 67475-56-3 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
3d Animation Molecule Structure of 67475-56-3
Chemical Structure| 67475-56-3
Chemical Structure| 67475-56-3
Structure of 67475-56-3 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Bulk Inquiry Add To Cart

Quality Control of [ 67475-56-3 ]

Related Doc. of [ 67475-56-3 ]

Alternatived Products of [ 67475-56-3 ]

Product Details of [ 67475-56-3 ]

CAS No. :67475-56-3 MDL No. :MFCD03618459
Formula : C7H6ClFO3S Boiling Point : -
Linear Structure Formula :- InChI Key :LUEBMKPHZDSPFH-UHFFFAOYSA-N
M.W :224.64 Pubchem ID :2783409
Synonyms :

Safety of [ 67475-56-3 ]

Signal Word:Danger Class:8
Precautionary Statements:P280-P305+P351+P338-P310 UN#:3261
Hazard Statements:H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 67475-56-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 67475-56-3 ]
  • Downstream synthetic route of [ 67475-56-3 ]

[ 67475-56-3 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 459-60-9 ]
  • [ 67475-56-3 ]
YieldReaction ConditionsOperation in experiment
84.6% at 0 - 20℃; l-fluoro-4-methoxybenzene (10.0 g, 0.079mol) was added dropwise to sulfurochloridic acid (31.4ml, 0.474mol) at 00C, The mixture was stirred at room temperature for about 6h, after which it was added dropwise into ice water. The mixture was extracted with CH2Cl2 three times. The combined extracts were washed with brine, dried over sodium sulfate and concentrated in vacuo to give the title product (15.Og, 84.6percentyield).1H NMR (300 MHz, DMSO-d6) δ 3.74 (s, 3H), 6.97 (dd, J= 4.3, 8.9 Hz, IH), 7.13 (dt, J= 3.4, 8.6 Hz, IH), 7.41 (dd, J= 3.3, 8.8 Hz, IH)
70% With chlorosulfonic acid In dichloromethane at 0 - 5℃; for 3 h; Inert atmosphere General procedure: A solution of the respective anisole (175 mmol) in CH2Cl2 (50 mL) was added dropwise to a 0 °C chlorosulfonic acid (100 mL) so as to maintain the reaction temperature below 5 °C. After the addition was complete, the reaction mixture was stirred for 3 h and poured over ice. The organic phase was separated, washes with water, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by short-path chromatography on silica gel using 10percent ethyl acetate in hexanes as eluent to provide the analytically pure target compound.
56% at 25℃; for 3 h; To a stirred CISO3H (50 mL) was added l-fiuoro-4-methoxy-benzene (10.0 g, 79.4 mmol) dropwise at 25°C. The mixture was stirred at this temperature for 3 hours. The mixture was poured into ice water (200 mL) and extracted with EtOAc (200 mL). The organic layer was wshed with brine (100 mL), dried over Na2S04 and evaporated in vacuum to give 12 g of crude product. The crude was purifed by silica gel column chromatography (PE/EtOAc, 20/1) to give 10.0 g of 5-fluoro-2-methoxy-benzenesulfonyl chloride (yield: 56percent) as yellow oil
Reference: [1] Patent: WO2010/31, 2010, A1, . Location in patent: Page/Page column 86
[2] Tetrahedron, 2016, vol. 72, # 47, p. 7570 - 7578
[3] Patent: WO2013/126608, 2013, A1, . Location in patent: Paragraph 00812
[4] Patent: WO2005/18529, 2005, A2, . Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 8, p. 1735 - 1746
[6] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 1, p. 31 - 34
[7] Patent: WO2005/18529, 2005, A2, . Location in patent: Page/Page column 54
  • 2
  • [ 371-41-5 ]
  • [ 67475-56-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 8, p. 1735 - 1746
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 67475-56-3 ]

Fluorinated Building Blocks

Chemical Structure| 1261825-36-8

[ 1261825-36-8 ]

4,5-Difluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.97

Chemical Structure| 887344-39-0

[ 887344-39-0 ]

2-(4-Fluorophenoxy)benzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1214377-19-1

[ 1214377-19-1 ]

4-Fluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1208074-96-7

[ 1208074-96-7 ]

2,3-Difluoro-6-methoxybenzene-1-sulfonyl chloride

Similarity: 0.90

Aryls

Chemical Structure| 1261825-36-8

[ 1261825-36-8 ]

4,5-Difluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.97

Chemical Structure| 887344-39-0

[ 887344-39-0 ]

2-(4-Fluorophenoxy)benzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1214377-19-1

[ 1214377-19-1 ]

4-Fluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1208074-96-7

[ 1208074-96-7 ]

2,3-Difluoro-6-methoxybenzene-1-sulfonyl chloride

Similarity: 0.90

Sulfonyl Chlorides

Chemical Structure| 1261825-36-8

[ 1261825-36-8 ]

4,5-Difluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.97

Chemical Structure| 887344-39-0

[ 887344-39-0 ]

2-(4-Fluorophenoxy)benzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1214377-19-1

[ 1214377-19-1 ]

4-Fluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1208074-96-7

[ 1208074-96-7 ]

2,3-Difluoro-6-methoxybenzene-1-sulfonyl chloride

Similarity: 0.90

Chlorides

Chemical Structure| 1261825-36-8

[ 1261825-36-8 ]

4,5-Difluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.97

Chemical Structure| 887344-39-0

[ 887344-39-0 ]

2-(4-Fluorophenoxy)benzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1214377-19-1

[ 1214377-19-1 ]

4-Fluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1208074-96-7

[ 1208074-96-7 ]

2,3-Difluoro-6-methoxybenzene-1-sulfonyl chloride

Similarity: 0.90

Ethers

Chemical Structure| 1261825-36-8

[ 1261825-36-8 ]

4,5-Difluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.97

Chemical Structure| 887344-39-0

[ 887344-39-0 ]

2-(4-Fluorophenoxy)benzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1214377-19-1

[ 1214377-19-1 ]

4-Fluoro-2-methoxybenzene-1-sulfonyl chloride

Similarity: 0.96

Chemical Structure| 1208074-96-7

[ 1208074-96-7 ]

2,3-Difluoro-6-methoxybenzene-1-sulfonyl chloride

Similarity: 0.90