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Chemical Structure| 675112-01-3 Chemical Structure| 675112-01-3

Structure of 675112-01-3

Chemical Structure| 675112-01-3

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Product Details of [ 675112-01-3 ]

CAS No. :675112-01-3
Formula : C16H22N4O3
M.W : 318.37
SMILES Code : O=C(C1=CN=C(N(CC)N=C2)C2=C1NC3CCOCC3)OCC

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Application In Synthesis of [ 675112-01-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 675112-01-3 ]

[ 675112-01-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33024-60-1 ]
  • [ 30720-25-3 ]
  • [ 675112-01-3 ]
YieldReaction ConditionsOperation in experiment
Intermediate 1 (2. [5G)] was dissolved in acetonitrile [(15ML).] 4-Aminotetrahydropyran hydrochloride [(1.] [LG)] and N, N-diisopropylethylamine (9. [4ML)] were added and the mixture stirred under nitrogen at [85°C] for 16h. A trace of starting material remained, so an additional portion of 4-aminotetrahydropyran hydrochloride [(O.] [L] lg) was added and stirring continued at [85°C] for a further [16H.] The mixture was then concentrated in vacuo. The residue was partitioned between DCM and water. The layers were separated and the organic layer was washed with further water [(2X20ML)] then dried [(NA2S04)] and concentrated in vacuo. The residue was further purified by chromatography using Biotage (silica, 90g), eluting with cyclohexane: ethyl acetate to afford Example 3 (2.45g). LCMS showed MH+ [= 319] ; TRET = 2. [90MIN.]
 

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