[ CAS No. 67730-09-0 ]

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Quality Control of [ 67730-09-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 67730-09-0 ]

Product Details of [ 67730-09-0 ]

CAS No. :	67730-09-0	MDL No. :	MFCD00023438
Formula :	C₇H₉N₃O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	167.17 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 67730-09-0 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501	UN#:
Hazard Statements:	H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 67730-09-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 67730-09-0 ]

[ 67730-09-0 ] Synthesis Path-Downstream 1~11

1
[ 4548-45-2 ]
[ 75-04-7 ]
[ 67730-09-0 ]

Yield	Reaction Conditions	Operation in experiment
71.1%	In dimethyl sulfoxide for 5h; Ambient temperature;
	In ethanol	16 Stage 1: 2-ethyl-amino-5-nitro-pyridine Stage 1: 2-ethyl-amino-5-nitro-pyridine 10 g of 2-chloro-5-nitropyridine are mixed with 30 ml of ethyl amine. After a few minutes an exothermic reaction starts. On its completion stirring is continued for 30 minutes. The mixture is poured on 150 g of ice and filtered with suction from the precipitated crystals. On recrystallizing from ethanol 9.6 g of yellow crystals having a melting point of 118° C. are obtained. 1 H-NMR Spectrum (in CDCl3): 9.01 (d, J=3 Hz, 6-H), 8.18 (dd, J1 =3 Hz, J2 =10 Hz, 4-H), 6.37 (d, J2 =10 Hz, 3-H), 5.5 (broad, NH), 3.46 (dq, J1 =6 Hz, NH-coupling; J2 =7 Hz, CH2), 1.31 (t, J=7 Hz, --CH3).
	In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate	I.N.T.23 Ethyl-(5-nitro-pyridin-2-yl)-amine EXAMPLE INT23 Ethyl-(5-nitro-pyridin-2-yl)-amine 395 mg of 2-chloro-5-nitro-pyridine and 2.5 ml of a 1 M solution of ethylamine in tetrahydrofuran are dissolved in 10 ml of DMSO and stirred for 4 hours at 50° C. The reaction mixture is mixed with ethyl acetate and washed three times with semi-saturated sodium bicarbonate solution. The organic phase is dried on sodium sulfate. After purification by chromatography on silica gel, 430 mg of the title compound is obtained. 1H-NMR (DMSO-d6): δ=1.17 (t, 3H); 3.40 (m, 2H); 6.53 (d, 1H); 8.00-8.23 (m, 2H); 8.91 (d, 1H) ppm.

In tetrahydrofuran; dimethyl sulfoxide at 50℃; for 4h;

Reference： [1]Kijima, Atsushi; Sekiguchi, Shizen [Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602]
[2]Current Patent Assignee: KKR & CO LP - US4950302, 1990, A
[3]Current Patent Assignee: BAYER AG - US2007/37862, 2007, A1
[4]Current Patent Assignee: BAYER AG - WO2005/42505, 2005, A1 Location in patent: Page/Page column 57

2
[ 108-24-7 ]
[ 67730-09-0 ]
[ 115474-10-7 ]

Yield	Reaction Conditions	Operation in experiment
93%	With acetic acid for 9.5h; Heating;

Reference： [1]Kijima, Atsushi; Sekiguchi, Shizen [Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602]

3
[ 115474-10-7 ]
[ 64-19-7 ]
[ 67730-09-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide In water at 50℃;

Reference： [1]Kijima, Atsushi; Sekiguchi, Shizen [Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602]

4
potassium 5-nitropyridine-2-sulfonate [ No CAS ]
[ 109-89-7 ]
[ 20168-70-1 ]
[ 67730-09-0 ]

Yield	Reaction Conditions	Operation in experiment
1: 27 mg 2: 44 mg	In N,N-dimethyl-formamide for 20h; Heating;

Reference： [1]Bakke, Jan M.; Sletvold, Ingrid [Organic and Biomolecular Chemistry, 2003, vol. 1, # 15, p. 2710 - 2715]

5
[ 5418-51-9 ]
[ 67730-09-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 89.1 percent / PCl₅, POCl₃ / 3 h / 110 °C 2: 71.1 percent / dimethylsulfoxide / 5 h / Ambient temperature

Reference： [1]Kijima, Atsushi; Sekiguchi, Shizen [Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602]

6
[ 4214-76-0 ]
[ 67730-09-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 51.2 percent / conc. H₂SO₄, NaNO₂ / H₂O / 0.5 h / 0 °C 2: 89.1 percent / PCl₅, POCl₃ / 3 h / 110 °C 3: 71.1 percent / dimethylsulfoxide / 5 h / Ambient temperature

Reference： [1]Kijima, Atsushi; Sekiguchi, Shizen [Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602]

7
[ 67730-09-0 ]
2-(N-ethylamino)-5-aminopyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	With palladium 10% on activated carbon; hydrogen In ethyl acetate for 5h;
	With hydrogen In ethanol at 20℃; for 4h;

Reference： [1]Kelly, Brendan; McMullan, Michela; Muguruza, Carolina; Ortega, Jorge E.; Meana, J. Javier; Callado, Luis F.; Rozas, Isabel [Journal of Medicinal Chemistry, 2015, vol. 58, # 2, p. 963 - 977]
[2]Current Patent Assignee: BAYER AG - WO2005/42505, 2005, A1 Location in patent: Page/Page column 58

8
[ 37059-57-7 ]
[ 67730-09-0 ]

Yield	Reaction Conditions	Operation in experiment
50%	With sulfuric acid; potassium nitrate In water at 20℃; for 5h;

9
[ 67730-09-0 ]
1-[6-(ethylamino)pyridin-3-yl]-2,3-di(tert-butoxycarbonyl)guanidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 2280.15 Torr 2: triethylamine; mercury dichloride / dichloromethane / 0 - 20 °C

10
[ 67730-09-0 ]
C₂₀H₃₁N₅O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 2280.15 Torr 2: triethylamine; mercury dichloride / dichloromethane / 0 - 20 °C

11
[ 67730-09-0 ]
C₁₀H₁₅N₅*ClH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 2280.15 Torr 2: triethylamine; mercury dichloride / dichloromethane / 0 - 20 °C 3: hydrogenchloride / isopropyl alcohol; dichloromethane; 1,4-dioxane / 55 °C

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[ CAS No. 67730-09-0 ]

Quality Control of [ 67730-09-0 ]

Related Doc. of [ 67730-09-0 ]

Product Details of [ 67730-09-0 ]

Safety of [ 67730-09-0 ]

Application In Synthesis of [ 67730-09-0 ]

[ 67730-09-0 ] Synthesis Path-Downstream 1~11

Precautionary Statements-General

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Health hazards

Environmental hazards

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