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Product Details of [ 6809-70-7 ]

CAS No. :6809-70-7 MDL No. :MFCD26793839
Formula : C22H46O12 Boiling Point : -
Linear Structure Formula :- InChI Key :PSVXZQVXSXSQRO-UHFFFAOYSA-N
M.W : 502.59 Pubchem ID :81260
Synonyms :
Chemical Name :3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontane-1,32-diol

Safety of [ 6809-70-7 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 6809-70-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6809-70-7 ]

[ 6809-70-7 ] Synthesis Path-Downstream   1~36

  • 1
  • undecaethylene glycol bis(allyl ether) [ No CAS ]
  • [ 6809-70-7 ]
YieldReaction ConditionsOperation in experiment
87% With water; toluene-4-sulfonic acid In methanol Heating;
  • 3
  • [ 124-63-0 ]
  • [ 6809-70-7 ]
  • [ 928211-39-6 ]
YieldReaction ConditionsOperation in experiment
With triethylamine In dichloromethane at 23℃; for 2h;
  • 4
  • [ 57671-28-0 ]
  • [ 6809-70-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 23 °C 1.2: 32 percent / tetrahydrofuran / 12 h / 23 °C 2.1: 89 percent / H2 / Pd/C / ethanol / 2 h / 23 °C
  • 5
  • [ 6809-70-7 ]
  • [ 928211-42-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C 3.1: 99 percent / H2 / Pd/C / ethanol / 2 h / 23 °C
  • 6
  • [ 6809-70-7 ]
  • 1,2-bis-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethane [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 2 h / 23 °C 2: NaN3 / dimethylformamide / 16 h / 50 °C
  • 7
  • [ 6809-70-7 ]
  • 2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethylamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 2 h / 23 °C 2: NaN3 / dimethylformamide / 16 h / 50 °C 3: H2; HCl / Pd/C / ethanol
  • 8
  • [ 6809-70-7 ]
  • [ 928211-36-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: Et3N / CH2Cl2 / 2 h / 23 °C 2: NaN3 / dimethylformamide / 16 h / 50 °C 3: H2; HCl / Pd/C / ethanol 4: 35 percent / EDC*HCl; DIEA / dimethylformamide / 23 °C
  • 9
  • [ 6809-70-7 ]
  • 1,2-bis-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethane [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C 3.1: 99 percent / H2 / Pd/C / ethanol / 2 h / 23 °C 4.1: Et3N / CH2Cl2 / 2 h / 23 °C 5.1: NaN3 / dimethylformamide / 16 h / 50 °C
  • 10
  • [ 6809-70-7 ]
  • C43H71N5O15S3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: Et3N / CH2Cl2 / 2 h / 23 °C 2: NaN3 / dimethylformamide / 16 h / 50 °C 3: H2; HCl / Pd/C / ethanol 4: 35 percent / EDC*HCl; DIEA / dimethylformamide / 23 °C 5: 36 percent / aq. NaHCO3 / acetone / 2 h / 23 °C
  • 11
  • [ 6809-70-7 ]
  • C44H90O26S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C 3.1: 99 percent / H2 / Pd/C / ethanol / 2 h / 23 °C 4.1: Et3N / CH2Cl2 / 2 h / 23 °C
  • 12
  • [ 6809-70-7 ]
  • C56H98O22 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C
  • 13
  • [ 6809-70-7 ]
  • C42H88N2O20*2ClH [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C 3.1: 99 percent / H2 / Pd/C / ethanol / 2 h / 23 °C 4.1: Et3N / CH2Cl2 / 2 h / 23 °C 5.1: NaN3 / dimethylformamide / 16 h / 50 °C 6.1: H2; HCl / Pd/C / ethanol
  • 14
  • [ 6809-70-7 ]
  • [ 928211-44-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C 3.1: 99 percent / H2 / Pd/C / ethanol / 2 h / 23 °C 4.1: Et3N / CH2Cl2 / 2 h / 23 °C 5.1: NaN3 / dimethylformamide / 16 h / 50 °C 6.1: H2; HCl / Pd/C / ethanol 7.1: 31 percent / 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride; DIEA / dimethylformamide / 23 °C
  • 15
  • [ 6809-70-7 ]
  • C63H111N5O25S3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: Et3N / CH2Cl2 / 2 h / 23 °C 2.1: NaH / tetrahydrofuran / 23 °C 2.2: 724 mg / tetrahydrofuran / 12 h / 23 °C 3.1: 99 percent / H2 / Pd/C / ethanol / 2 h / 23 °C 4.1: Et3N / CH2Cl2 / 2 h / 23 °C 5.1: NaN3 / dimethylformamide / 16 h / 50 °C 6.1: H2; HCl / Pd/C / ethanol 7.1: 31 percent / 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride; DIEA / dimethylformamide / 23 °C 8.1: 31 percent / aq. NaHCO3 / acetone / 2 h / 23 °C
  • 16
  • [ 112-60-7 ]
  • [ 6809-70-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: NaH / tetrahydrofuran / 3 h / 100 °C 2: aq. NaOH / tetrahydrofuran / 20 h / 20 °C 3: 66 percent / NaH / tetrahydrofuran / 24 h / Heating 4: 97 percent / hydrogen / Pd/C / ethanol / 24 h / 100 °C / 6080 Torr
Multi-step reaction with 4 steps 1.1: sodium hydride / tetrahydrofuran / 3 h / 66 - 67 °C 2.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Cooling with ice 3.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 3.2: 0 - 20 °C 4.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 11251.1 - 15001.5 Torr / Autoclave
  • 17
  • [ 86259-87-2 ]
  • [ 6809-70-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: aq. NaOH / tetrahydrofuran / 20 h / 20 °C 2: 66 percent / NaH / tetrahydrofuran / 24 h / Heating 3: 97 percent / hydrogen / Pd/C / ethanol / 24 h / 100 °C / 6080 Torr
Multi-step reaction with 3 steps 1.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Cooling with ice 2.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 2.2: 0 - 20 °C 3.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 11251.1 - 15001.5 Torr / Autoclave
  • 18
  • [ 89346-82-7 ]
  • [ 6809-70-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 66 percent / NaH / tetrahydrofuran / 24 h / Heating 2: 97 percent / hydrogen / Pd/C / ethanol / 24 h / 100 °C / 6080 Torr
Multi-step reaction with 2 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 1.2: 0 - 20 °C 2.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 11251.1 - 15001.5 Torr / Autoclave
  • 19
  • [ 6809-70-7 ]
  • C38H78O20 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 1.2: 0 - 20 °C 2.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 11251.1 - 15001.5 Torr / Autoclave
  • 20
  • [ 6809-70-7 ]
  • C48H98O24 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 1.2: 0 - 20 °C 2.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 11251.1 - 15001.5 Torr / Autoclave 3.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 3.2: 0 - 20 °C
  • 21
  • [ 89346-82-7 ]
  • [ 6809-70-7 ]
  • C52H90O20 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70.8% Stage #1: 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol With potassium <i>tert</i>-butylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate In tetrahydrofuran at 0 - 20℃;
  • 22
  • [ 111-77-3 ]
  • [ 6809-70-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Cooling with ice 2.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 0 °C 2.2: 0 - 20 °C 3.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 11251.1 - 15001.5 Torr / Autoclave
  • 23
  • [ 6809-70-7 ]
  • [4-[2-[4-(hydroxymethyl)phenoxy]undecaethoxy]phenyl]methanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine; dmap / dichloromethane / 3 h / Cooling with ice 2: potassium carbonate / acetonitrile / Reflux
  • 24
  • [ 6809-70-7 ]
  • 1-(chloromethyl)-4-[2-[4-(chloromethyl)phenoxy]undecaethoxy]benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine; dmap / dichloromethane / 3 h / Cooling with ice 2: potassium carbonate / acetonitrile / Reflux 3: thionyl chloride; 1,2,3-Benzotriazole / dichloromethane / 24 h
  • 25
  • [ 98-59-9 ]
  • [ 6809-70-7 ]
  • 3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% With dmap; triethylamine In dichloromethane for 3h; Cooling with ice; 13a Example 13a. 2-[2-(p-Tolylsulfonyloxy)undecaethoxy ]ethyl 4-methylbenzenesulfonate. A mixture of NEt3 (0.57 mL, 4.12 mmol), TsCl (697 mg, 3.66 mmol) and DMAP (22 mg,0.18 mmol) were combined in CH2Ch (4 mL). This solution was cooled in an ice bath andto it was added undecaethylene glycol (500 mg, 0.91 mmol). The reaction was stirred for3h and was then concentrated in vacuum. Purification of the crude by flashchromatography using as eluent a mixture of cHex/ CH2ClVMeOH (100/0/0 to 0/94/4)gave the desired product as a colorless oil (m = 737 mg, 94%). 1H NMR (300 MHz,CD2Ch): o (ppm) 2.44 (s, 6H), 3.54- 3.60 (m, 40H), 3.64 (t, J = 4.7 Hz, 4H), 4.12 (t, J =4.7 Hz, 4H), 7.37 (d, J = 8.3 Hz, 4H), 7.78 (d, J = 8.3 Hz, 4H). MS: [M+N~t m/z = 872.
  • 26
  • [ 6809-70-7 ]
  • C51H100O26 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: sulfuric acid / 24 h / 25 °C 2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 0.25 h / Molecular sieve 2.2: 48 h / 20 °C / Molecular sieve
  • 27
  • [ 6809-70-7 ]
  • C47H96O24 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: sulfuric acid / 24 h / 25 °C 2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 0.25 h / Molecular sieve 2.2: 48 h / 20 °C / Molecular sieve 3.1: potassium carbonate; water / methanol / 25 °C
  • 28
  • [ 6809-70-7 ]
  • C54H102O26S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: sulfuric acid / 24 h / 25 °C 2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 0.25 h / Molecular sieve 2.2: 48 h / 20 °C / Molecular sieve 3.1: potassium carbonate; water / methanol / 25 °C 4.1: triethylamine / dichloromethane / 20 °C
  • 29
  • [ 6809-70-7 ]
  • C47H95N3O23 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sulfuric acid / 24 h / 25 °C 2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 0.25 h / Molecular sieve 2.2: 48 h / 20 °C / Molecular sieve 3.1: potassium carbonate; water / methanol / 25 °C 4.1: triethylamine / dichloromethane / 20 °C 5.1: sodium azide / N,N-dimethyl-formamide / 80 °C
  • 30
  • [ 6809-70-7 ]
  • C47H97NO23 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sulfuric acid / 24 h / 25 °C 2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 0.25 h / Molecular sieve 2.2: 48 h / 20 °C / Molecular sieve 3.1: potassium carbonate; water / methanol / 25 °C 4.1: triethylamine / dichloromethane / 20 °C 5.1: sodium azide / N,N-dimethyl-formamide / 80 °C 6.1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C
  • 31
  • [ 64-19-7 ]
  • [ 6809-70-7 ]
  • C24H48O13 [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% Stage #1: acetic acid; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol With sulfuric acid at 25℃; for 24h; Stage #2: With sodium hydrogencarbonate 3.1 The first step, the synthesis of compound H1: Weigh eleven ethylene glycol (50.2g, 100mmol) and acetic acid (2g, 33.3mmol) in a 250ml single-necked flask stirring 0.04ml concentrated sulfuric acid was added dropwise in the reaction,Stirring at 25 degrees 24h, adding 8ml saturated sodium bicarbonate solution and stirring overnight,To the reaction was added 20 ml of water and extracted with dichloromethane 50 * 8,The organic layer was dried over anhydrous sodium sulfate,The solvent was removed by chromatography on a column of DCM: MeOH 20: 1 to give 11.412 g of pure product. Yield 63%.
  • 32
  • [ 6809-70-7 ]
  • C42H60N2O16 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 °C 2.1: sodium periodate; ruthenium(III) chloride trihydrate / dichloromethane; acetonitrile; water / 0 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C 3.2: 3 h / Reflux
  • 33
  • [ 6809-70-7 ]
  • C22H44O14S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 °C 2: sodium periodate; ruthenium(III) chloride trihydrate / dichloromethane; acetonitrile; water / 0 °C
  • 34
  • [ 6809-70-7 ]
  • C22H44O13S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; thionyl chloride; triethylamine In dichloromethane at 0℃; General procedure for the synthesis of macrocyclic sulfate (MCS). General procedure: (Using the synthesis of macrocyclic sulfate 6a as an example). To a stirring solution of tetra(ethylene glycol) 5a (40.0 g, 205.95 mmol), triethylamine (100.73 g, 988.56 mmol), and DMAP (1.26 g, 10.30 mmol) in CH2Cl2 (3 L) at 0 °C was slowly added a solution of SOCl2 (50.30 g, 411.90 mmol, in 50 mL CH2Cl2). After the addition, the stirring mixture was warmed to 25 °C and monitored with TLC until the complete consumption of tetra(ethylene glycol). The reaction was quenched with 1.5 L water. The organic layer was collected, filtrated through a pad of silica gel, and concentrated under vacuum to provide the macrocyclic sulfite intermediate as brownish oil which was used directly in the next step. To the solution of macrocyclic sulfite in a mixture of CH2Cl2 (200 mL), CH3CN (200 mL), and water (300 mL) at 0 °C was added NaIO4 (52.86 g, 247.14 mmol) and RuCl3•3H2O (0.27 g, 1.03 mmol). The stirring mixture was gradually warmed to 25 °C and monitored with TLC. Upon complete consumption of the macrocyclic sulfite, the reaction mixture was filtered through a pad of Celite. Organic layer was collected, washed with brine, concentrated under vacuum, and recrystallized in methanol at -20 °C to afford the macrocyclic sulfate 6a as clear crystal (25.14 g, 47% yield).
  • 35
  • [ 53123-88-9 ]
  • [ 6809-70-7 ]
  • (21E,23E,25E,26E,50R,51S,52R,53R,55S,57S,60S,61R,62R,71R)-61,71-dihydroxy-59-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-60-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-62-methoxy-50,51,52,53,63,64-hexamethyl-82,83-dioxa-72-azatricyclohexatriaconta-21,23,25(63),26(64)-tetraene-65,66,67,68,69-pentone [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% With toluene-4-sulfonic acid In tetrahydrofuran at 0 - 20℃; for 2h; 45.1 Step 1: Synthesis of (21E,23E,25E,26E,50R,51S,52R,53R,55S,57S,60S,61R,62R,71R)- 61,71-dihydroxy-59-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy] ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-60-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3- methoxy-cyclohexyl]-1-methyl-ethyl]-62-methoxy-50,51,52,53,63,64-hexamethyl-82,83- dioxa-72-azatricyclohexatriaconta-21,23,25(63),26(64)-tetraene-65,66,67,68,69-pentone (I- 96): To a solution of rapamycin (0.2 g, 0.22 mmol) and 4-methylbenzenesulfonic acid (0.19 g, 1.09 mmol) in THF (6 mL) was added 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2- hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol (1.10 g, 2.19 mmol) at 0 °C and the reaction was stirred at 20 °C for 2 h then poured into sat. NaHCO3 (30 mL) and extracted with EtOAc (40 mL× 3). The combined organic layers were washed with water (40 mL), brine (40 mL), dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by reverse phase chromatography (C18, CH3CN: H2O = 51:49) to obtain (21E,23E,25E,26E,50R,51S,52R,53R,55S,57S,60S,61R,62R,71R)-61,71- dihydroxy-59-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy] ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-60-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3- methoxy-cyclohexyl]-1-methyl-ethyl]-62-methoxy-50,51,52,53,63,64-hexamethyl-82,83- dioxa-72-azatricyclohexatriaconta-21,23,25(63),26(64)-tetraene-65,66,67,68,69-pentone (I- 96: 61 mg, 20% yield) as a colorless oil. ESI-MS (EI+, m/z): 1408.0 [M+Na]+. 1H NMR (500 MHz, CDCl3) d 6.41- 5.84 (m, 4H), 5.61- 5.08 (m, 4H), 4.79 (s, 1H), 4.32- 4.05 (m, 1H), 3.89- 3.46 (m, 44H), 3.46- 3.16 (m, 12H), 2.98- 2.50 (m, 7H), 2.32 (s, 2H), 2.15- 1.89 (m, 4H), 1.82- 1.68 (m, 8H), 1.56- 1.16 (m, 14H), 1.12- 0.82 (m, 18H), 0.74- 0.56 (m, 1H).
  • 36
  • [ 7693-46-1 ]
  • [ 6809-70-7 ]
  • C36H52N2O20 [ No CAS ]
YieldReaction ConditionsOperation in experiment
8% With dmap; triethylamine In dichloromethane at 0 - 20℃;
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