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CAS No. : | 69661-42-3 | MDL No. : | MFCD09041760 |
Formula : | C8H5FN2OS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GHVBYTWFUWPYDX-UHFFFAOYSA-N |
M.W : | 196.20 | Pubchem ID : | 12448882 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20℃; for 16h; | A suspension of 6-fluoro-2-mercaptoquinazolin-4(3H)-one (0.5 g, 2.55 mmol), 3-bromopropanoic acid (0.390 g, 2.55 mmol) (Ukraine organics) and potassium carbonate (1.057 g, 7.65 mmol) in ACN (8.49 ml) and DMF (2 mL) was stirred at ambient temperature for 16h. The reaction mixture was next acidified with 2 N HCl to pH 2 and extracted with DCM (3X100 mL). The combined organic extracts were passed through a phase separator and concentrated to obtain 3-((6-fluoro-4-oxo-3,4- dihydroquinazolin-2-yl)thio)propanoic acid (99%, inial yield) as white solid. This was used in next step without further purification. |