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[ CAS No. 6967-29-9 ] {[proInfo.proName]}

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Chemical Structure| 6967-29-9
Chemical Structure| 6967-29-9
Structure of 6967-29-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 6967-29-9 ]

CAS No. :6967-29-9 MDL No. :MFCD00124800
Formula : C12H16ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :LBJVHMAYBNQJBK-UHFFFAOYSA-N
M.W : 225.72 Pubchem ID :96338
Synonyms :

Safety of [ 6967-29-9 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P302+P352-P304+P340-P305+P351+P338-P332+P313-P337+P313 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 6967-29-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6967-29-9 ]

[ 6967-29-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 579-66-8 ]
  • [ 79-04-9 ]
  • [ 6967-29-9 ]
YieldReaction ConditionsOperation in experiment
82.72% With triethylamine; In dichloromethane; at 0 - 20℃; for 6h; General procedure: 2-chloroacetyl chloride (1.5 mmol) was added dropwise to a mixture of amine (1 mmol) and triethylamine (3 mmol) in 20 mL dichloromethane originally at 0 C with stirring. Then the resulting mixture was cooled to ambient temperature and stirred for 6 h. After removal of dichloromethane solvents on a rotary evaporator, water was added and extract with ethyl acetate (3 × 30 mL). The organic layer was combined and dried with sodium sulfate. The solution was evaporated to give the crude product, which was purified by Silica gel column chromatography with ethyl acetate-petroleum ether as eluent.
With triethylamine; In chloroform; at 0 - 5℃; for 2h; General procedure: An equimolar solution of ethyl-2-aminoacetate 2 (0.2 M) and triethyl amine (0.2 M) in dry chloroform (50 ml) was stirred at 0-5 C. Chloroacetyl chloride (0.21 M) was added drop wise for a period of about 30-45 min and later stirred for 24-30 h. The reaction was monitored through TLC by staining the plates with Ninhydrin reagent. After completion of the reaction, solvent was distilled off. The solid obtained was washed with NaHCO3, later with water and dried over anhydrous Na2SO4.
With sodium carbonate; In water; toluene; at 20℃; for 2h;Cooling with ice; 10g of sodium carbonate (0.1mol) dissolved in water was added 200ml of toluene to dissolve. To this was added 10g <strong>[579-66-8]2,6-diethylaniline</strong> (0.068mol). It was placed in ice bath and was added dropwise 7.7g chloroacetyl chloride (0.068mol) and was stirred for 2 hours at room temperature. Completion of the reaction was monitored by TLC. The reaction mixture was suction filtered, washed with water, and washed with petroleum ether, giving a pink solid (VII-1).
With triethylamine; In dichloromethane; at 0 - 25℃; for 20h; General procedure: 2-Chloroacetyl chloride (24 mmol) wasslowly added dropwise to a mixture of various anilines(20 mmol) and Et3N (24 mmol) in anhydrous CH2Cl2(20 mL) at 0 C. The reaction mixture was warmed to roomtemperature and stirred for an additional 20 h. After the solventwas removed under reduced pressure, the residue waswashed with ice water, and the precipitate was separatedby filtration. The crude product was purified by crystallizationusing a mixture of ether/hexane (2a-r).

  • 2
  • [ 1486-50-6 ]
  • [ 6967-29-9 ]
  • [ 1429436-83-8 ]
YieldReaction ConditionsOperation in experiment
100.03 mg With potassium carbonate In dichloromethane at 20℃; General procedure for the synthesis of 16a-y General procedure: The acyl chloride (∼0.381 mmol) was added to a mixture of 13a-k (∼0.241 mmol) and potassium carbonate (0.508 mmol) in 10 mL of dichloromethane at room temperature with stirring. The completion of the reaction was monitored by TLC and took 4-8 h. The precipitate was collected by filtration and washed with water to yield the crude product. Each compound was purified by column chromatography on silica gel using dichloromethane/ethyl acetate as eluent or crystallized from suitable solvent to give pure target compounds 16a-y.
  • 3
  • [ 593-71-5 ]
  • [ 20458-99-5 ]
  • [ 6967-29-9 ]
YieldReaction ConditionsOperation in experiment
95% With methyllithium lithium bromide In diethyl ether at -78℃;
95% With methyllithium; lithium bromide In diethyl ether at -78℃; for 0.5h; chemoselective reaction; Chemoselective Addition of Lithium Carbenoids to Isocyanates; General Procedure 1 (GP1) General procedure: To a cooled (-78°C) solution of isocyanate (1.0 equiv) in dry Et2O (1 M concentration) was added the dihalomethane derivative (1.5 equiv). After 2 min, an ethereal solution of 1.5 M MeLi-LiBr (1.25equiv) was added dropwise over 5 min. The resulting solution was stirred for the appropriate time (see Table 1 and Scheme 2) at that temperature. Sat. aq NH4Cl was added (2 mL/mmol substrate) and the cooling bath was removed, the mixture was stirred till it reached r.t., and then it was extracted with additional Et2O (2 × 5 mL) and washed with water (5 mL) and brine (10 mL). The organic phase was dried (anhyd Na2SO4), filtered, and the solvent removed under reduced pressure to give pure samples of haloacetamides.
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