Home Cart Sign in  
Chemical Structure| 72580-54-2 Chemical Structure| 72580-54-2
Chemical Structure| 72580-54-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Synonyms: (R)-Pyrrolidine-3-carboxylic acid

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of H-D-β-Pro-OH

CAS No. :72580-54-2
Formula : C5H9NO2
M.W : 115.13
SMILES Code : OC(=O)[C@@H]1CCNC1
Synonyms :
(R)-Pyrrolidine-3-carboxylic acid
MDL No. :MFCD08272856
InChI Key :JAEIBKXSIXOLOL-SCSAIBSYSA-N
Pubchem ID :1501970

Safety of H-D-β-Pro-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-D-β-Pro-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72580-54-2 ]

[ 72580-54-2 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 501-53-1 ]
  • [ 72580-54-2 ]
  • [ 192214-06-5 ]
YieldReaction ConditionsOperation in experiment
39% With sodium hydroxide; In water; for 2.0h; To a solution of 103 20a (500mg, 1.616mmol) in 82 MeOH (13mL) 10% 108 Pd/C (179mg) was added and the mixture was allowed to stir for 20h at 25C under H2 atmosphere. The reaction was filtered on Celite and the filtrate was concentrated under reduced pressure quantitatively providing (R)-pyrrolidine-3-carboxylic acid submitted to the next step without further purification. To a solution of this latter (460mg, 3.995mmol) in 2N 109 NaOH (2mL) 110 benzylchloroformate (740muL, 5.194mmol) and 4N NaOH (1.5mL) were added and the mixture was stirred at 0C for 2h. The reaction was extracted with diethyl ether. The aqueous layer was adjusted to pH=2 with 10% HCl at 0C and extracted with EtOAc. The organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (CH2Cl2/MeOH 9:1) affording (R)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid (39%). 1H NMR (300MHz, CDCl3) delta 9.17 (br, 1H), 7.44-7.32 (m, 5H), 5.18 (s, 2H), 4.73 (s, 1H), 3.73-3.47 (m, 3H), 3.19-3.09 (m, 1H), 2.24-2.13 (m, 2H); 13C NMR (75MHz, CDCl3) delta 177.0, 155.0, 136.6, 129.6, 128.6, 128.1, 127.6, 127.1, 67.2, 48.3/47.9, 45.7/45.3, 43.1/42.3, 28.8/28.2.
 

Historical Records

Technical Information

Categories