[ CAS No. 7299-86-7 ]

Name: 7299-86-7|2-(5,5-Dimethyl-1,3-dioxan-2-yl)-2-methylpropan-1-ol|95%
Brand: Ambeed
SKU: A1015109
Rating: 96 (28 reviews)

{[proInfo.proName]} ,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 7299-86-7

Structure of 7299-86-7 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Bulk Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 88K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 7299-86-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 7299-86-7 ]

SDS

Alternatived Products of [ 7299-86-7 ]

Product Details of [ 7299-86-7 ]

CAS No. :	7299-86-7	MDL No. :	MFCD22378746
Formula :	C₁₀H₂₀O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	188.26 g/mol	Pubchem ID :	-
Synonyms :

Calculated chemistry of of [ 7299-86-7 ]

Physicochemical Properties

Num. heavy atoms :	13
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	50.88
TPSA :	38.69 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.34 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.45
Log Po/w (XLOGP3) :	1.56
Log Po/w (WLOGP) :	1.4
Log Po/w (MLOGP) :	1.05
Log Po/w (SILICOS-IT) :	1.8
Consensus Log Po/w :	1.65

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.86
Solubility :	2.61 mg/ml ; 0.0139 mol/l
Class :	Very soluble
Log S (Ali) :	-1.98
Solubility :	1.96 mg/ml ; 0.0104 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.66
Solubility :	4.15 mg/ml ; 0.022 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.96

Safety of [ 7299-86-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 7299-86-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 7299-86-7 ]

[ 7299-86-7 ] Synthesis Path-Downstream 1~13

1
5,5-dimethyl-2-(1',1'-dimethyl-2'-hydroxyethyl)-4-hydroxy-1,3-dioxane [ No CAS ]
[ 126-30-7 ]
[ 7299-86-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride

Reference： [1]Spaeth; v. Szilagyi [Chemische Berichte, 1943, vol. 76, p. 949,954]

2
5,5-dimethyl-2-(1',1'-dimethyl-2'-hydroxyethyl)-4-hydroxy-1,3-dioxane [ No CAS ]
[ 7299-86-7 ]

Yield	Reaction Conditions	Operation in experiment
	With diethyl ether; hydrogen bromide Behandeln des Reaktionsprodukts in Essigsaeure mit Zink-Pulver und mit Bromwasserstoff in Essigsaeure;

Reference： [1]Spaeth; Pallan-Raschik [Monatshefte fur Chemie, 1948, vol. 79, p. 447]

3
[ 141-30-0 ]
[ 126-30-7 ]
[ 7299-86-7 ]
[ 117144-83-9 ]
[ 108288-02-4 ]

Yield	Reaction Conditions	Operation in experiment
0.84 g	With ammonium peroxydisulfate; sulfuric acid In water at 100℃; for 2h; Yields of byproduct given;

Reference： [1]Hackler, Ronald E.; Dreikorn, Barry A.; Johnson, George W.; Varie, David L. [Journal of Organic Chemistry, 1988, vol. 53, # 24, p. 5704 - 5709]

4
[ 597-31-9 ]
[ 126-30-7 ]
[ 7299-86-7 ]

Yield	Reaction Conditions	Operation in experiment
	In toluene at 95 - 130℃; for 4h;	7 By the similar procedure as in Example 1, 104 g of neopentyl glycol, 100 g of hydroxypivalilaldehyde and 400 g of toluene were charged, and the solution was heated while agitating. The dehydration reaction was continued at 95 to 130° C. for about 4 hours and terminated when 18 g of water formed were obtained and condensing of water stopped. The main component of the reaction product was confirmed to be the compound represented by the following structural formula from the results of NMR and LCMS analysis.
	With nafion In benzene Dean-Stark;	1 A synthesis of a 2-(5,5-dimethyl- 1,3-dioxane 2-yl)-2-methylpropan-1-oar 131.3 g of 2,2-dimethyl- 3-hydroxy-propionaldehyde (hydroxypivalaldehyde, the MITSUBISHI GAS CHEMICAL COMPANY INC. make, 99.8% of purity), 136.0 g of 2,2-dimethyl- 1,3-propanediol, and the benzene 705g, 3.0 g of granular Nafion (made by trade name "NR-50" sigma Aldrich) is stored in a 2-liter round bottom flask, it extracts out of a system using the Dean Stark trap, carrying out azeotropy of the water generated under ordinary pressure to benzene, and it was made to react until the distillate of water stopped. After filtering this, it was made to recrystallize by condensed and cooling, and the crystal of the 2-(5,5-dimethyl- 1,3-dioxane 2-yl)-2-methylpropan-1-oar was obtained. [Chemical formula 10]
	With Nafion NR-50 In benzene Dean-Stark;	1 Synthesis of 2-(5,5-dimethyl-1 ,3-dioxan-2-yl)-2-methylpropan-1 -ol In a 2 L round-bottom flask, 131.3 g of 2,2- dimethyl-3-hydroxy-propionaldehyde (hydroxypivalaldehyde, manufactured by MITSUBISHI GAS CHEMICAL COMPANY, INC., purity: 99.8%), 136.0 g of 2,2-dimethyl- 1,3-propanediol, 705 g of benzene, and 3.0 g of a particulate Nafion (product name: “NR-50”, manufactured by SigmaAldrich Co.) were contained, and allowed to react while water generated was azeotroped with the benzene under normal pressure to remove from the system by using a Dean-Stark trap until distillation of water was ceased. The resultant was filtered and then concentrated and cooled for recrystallization to afford a crystal of 2-(5,5-dimethyl-1 ,3- dioxan-2-yl)-2-methylpropan-1 -ol. The reaction formula of the reaction is shown in the formula (4)

Reference： [1]Current Patent Assignee: NIPPON KAYAKU CO LTD - US7169829, 2007, B2 Location in patent: Page/Page column 20
[2]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - JP2016/13989, 2016, A Location in patent: Paragraph 0041
[3]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - US2017/158855, 2017, A1 Location in patent: Paragraph 0085

5
[ 7299-86-7 ]
[ 55750-53-3 ]
[ 558483-53-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydroquinone In toluene at 95 - 130℃; for 5h;	7 Subsequently, the reaction mixture was added with 211 g of maleimide caproic acid, 3 g of sulfuric acid and 3 g of hydroquinone and heated while agitating. The dehydration reaction was continued at 95 to 130° C. for about 5 hours and terminated when 18 g of water formed were obtained. The reaction mixture was transferred to a 2-liter separating funnel, dissolved in 500 g of toluene, neutralized with 100 g of a 20% aqueous solution of NaOH and then washed three times with 200 g of a 15% aqueous solution of NaCl. The solvent was distilled off under a reduced pressure to obtain 360 g of a reaction product. The refractive index (25° C.) of the reaction product was 1.493 and the viscosity thereof was 1.3 Pa.s at 25° C. The main component of the reaction product was confirmed to be the compound represented by the following structural formula from the results of NMR and LCMS analysis.

Reference： [1]Current Patent Assignee: NIPPON KAYAKU CO LTD - US7169829, 2007, B2 Location in patent: Page/Page column 20-21

6
[ 7299-86-7 ]
[ 16090-01-0 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen In 1,4-dioxane at 230℃; for 3.5h;	5 Example 1 Reactions were performed in the same manner as in Example 2 except that reaction solvents and reaction conditions were changed. Catalysts, reaction solvents, reaction conditions, and reaction results are shown in Table 1.
	With hydrogen In 1,4-dioxane at 230℃; for 5h; Inert atmosphere;	2 A synthesis of 4-oxa 2-butyl-2-ethyl-6,6-dimethylheptan 1,7-diol In the 500-mL reactor made from SUS, the catalyst A3.0g, the 2-(5,5-dimethyl- 1,3-dioxane 2-yl)-2-methylpropan-1-oar 60.0g, and 240 g of 1,4-dioxane were put in, and nitrogen gas replaced the inside of a reactor. Then, the 8.5MPa filling of the hydrogen gas is carried out into a reactor, and it was made to react for 5 hours, carrying out a temperature rise to 230 degrees C which is reaction temperature, and maintaining hydrogen pressure at 13MPa. After having cooled after that, filtering the contents of the reactor and separating a catalyst, the object was obtained by carrying out recrystallization refining.
	With palladium on zirconium oxide; hydrogen In 1,4-dioxane at 230℃; for 5h; Inert atmosphere;	2 Synthesis of4-oxa-2,2,6,6-tetramethylheptane-1 ,7-diol(dineopentyl glycol) In a 500 mL SUS reactor, 3.0 g of the catalyst A,60.0 g of 2-(5,5-dimethyl-1 ,3-dioxan-2-yl)-2-methylpropan-1-ol obtained in Synthesis Example 1, and 240 g of 1,4- dioxane were contained, and the inside of the reactor was purged with nitrogen gas. Thereafier, the inside of the reactor was filled with hydrogen gas to a pressure of 8.5 MPa, and the temperature was elevated to the reaction temperature of 230° C., and a reaction was performed at 230° C. for 5 hours while the hydrogen pressure was retained at 13 MPa. Thereafter, the reactor was cooled and the content of the reactor was filtered to separate the catalyst, and then subjected to recrystallization purification to afford the intended product. The reaction formula of the reaction is shown in formula (5)

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - EP2939997, 2015, A1 Location in patent: Paragraph 0130
[2]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - JP2016/13989, 2016, A Location in patent: Paragraph 0045
[3]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - US2017/158855, 2017, A1 Location in patent: Paragraph 0091

7
[ 7299-86-7 ]
[ 16090-01-0 ]
[ 112548-49-9 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen In diethyl ether at 230℃; for 2h;	3 Example 3 Examples 3 to 6> Reactions were performed in the same manner as in Example 2 except that reaction solvents and reaction conditions were changed. Catalysts, reaction solvents, reaction conditions, and reaction results are shown in Table 1 Example 1> (0125) 0.60 g of an A1 catalyst, 2.40 g of 2-(5,5-dimethyl-[1,3]dioxane-2-yl)-2-methyl-propane-1-ol of raw material preparation example 1, and 24.0 g of diisopropylether were placed in a 100 mL SUS reactor vessel, and the reactor vessel was purged with nitrogen gas. Then, the reactor vessel was filled with hydrogen gas at 8.5 MPa. The temperature was increased to a reaction temperature of 230°C for the reaction for 2 hours. Then, the reactor vessel was cooled. The contents in the reactor vessel were sampled, and gas-chromatographically analyzed. (0126) As a result, the conversion of a compound (1) was 95.8%. The selectivity of 3-(3-hydroxy-2,2-dimethyl-propoxy)-2,2-dimethyl-propane-1-ol (hereinafter, represented as a "compound MMMM") of a compound (2) was 89.6%; the selectivity of 3-[3-(3-hydroxy-2,2-dimethyl-propoxy)-2,2-dimethyl-propoxy]-2,2-dimethyl-propane-1-ol (hereinafter, represented as a "compound MMMMMM") of a compound (3) was 4.2%; and the total of both the selectivities was 93.8%. (0127) The product materials were identified by the following method. The obtained reaction liquid was filtered to separate the catalyst. Then, the reaction liquid was recrystallized to obtain a product material. The structure of the product material was confirmed by subjecting the product material to NMR analysis. 1H NMR (500 MHz, CDCl3) δ 0.91 (3H x 2, 2s, Me2C x 2), 2.50-2.68 (2H, bs, OH x 2), 3.26 (4H, s, -CH2-O- x 2), 3.43 (4H, s, -CH2OH x2); 13C NMR (125 MHz, CDCl3) δ 21.8, 36.4, 70.8, 79.7. The obtained reaction liquid was subjected to chromatography to isolate a product material. The structure of the product material was confirmed by subjecting the product material to NMR analysis. 1H NMR (500 MHz, CDCl3) δ 0.89, 0.91 (3H x 6, 2s, Me2C x 3), 3.16, 3.25 (4H x 2, 2s, -CH2-O- x 4), 3.42 (4H, s, -CH2OH x2) 3.46 (2H, bs, OH x 2); 13C NMR (125 MHz, CDCl3) δ 21.8, 22.4, 36.0, 36.3, 71.5, 77.5, 80.1. (0128) From these results, when a polyether diol having a ring-opening structure formed by adding one hydrogen molecule to the compound (1) was generated, the compound (3) in which a neo skeleton included in the generated compound (2) was further added to the compound (2) was also confirmed to be simultaneously generated. Hereinafter, a reaction scheme in Example 1 will be shown.

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - EP2939997, 2015, A1 Location in patent: Paragraph 0125-0129; 0130

8
[ 122404-83-5 ]
[ 126-30-7 ]
[ 7299-86-7 ]

Yield	Reaction Conditions	Operation in experiment
	With Nafion ("NR-50") In benzene Dean-Stark; Reflux;	1 Preparation of 2-(5,5-Dimethyl-[1,3]dioxane-2-yl)-2-methyl-propane-1-ol (Preparation of 2-(5,5-Dimethyl-[1,3]dioxane-2-yl)-2-methyl-propane-1-ol) (0098) 131.3 g of 2,2-dimethyl-3-hydroxy-propionaldehyde (hydroxypivalaldehyde, manufactured by Mitsubishi Gas Chemical Company, Inc., purity: 99.8%), 136.0 g of 2,2-dimethyl-1,3-propanediol (neopentyl glycol (reagent) manufactured by Tokyo Chemical Industry Co., Ltd.), 705 g of benzene, and 3.0 g of granular Nafion ("NR-50" (trade name) manufactured by Sigma-Aldrich Corporation) were placed in a 2 L round bottom flask. Water generated under normal pressure was extracted out of a system using a Dean-Stark trap by an azeotrope together with benzene, and the reaction was performed until the distillation of the water stopped. This was filtered, and then recrystallized by condensing and cooling, to obtain a crystal of 2-(5,5-dimethyl-[1,3]dioxane-2-yl)-2-methyl-propane-1-ol. This synthetic reaction scheme will be shown below.

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - EP2939997, 2015, A1 Location in patent: Paragraph 0098-0099

9
[ 7299-86-7 ]
bis(pivalic acid)4-oxa 2,2,6,6-tetramethylheptane-1,7-diyl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ; hydrogen / 1,4-dioxane / 5 h / 230 °C / 63756.4 - 97509.8 Torr / Inert atmosphere 2: toluene-4-sulfonic acid / m-xylene / 150 - 160 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - JP2016/13989, 2016, A

10
[ 7299-86-7 ]
bis(2-ethylhexanoic acid) 4-oxa-2,2,6,6-tetramethylheptane-1,7-diyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ; hydrogen / 1,4-dioxane / 5 h / 230 °C / 63756.4 - 97509.8 Torr / Inert atmosphere 2: toluene-4-sulfonic acid / m-xylene / 160 - 170 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - JP2016/13989, 2016, A

11
[ 7299-86-7 ]
bis(3,5,5-trimethylhexanoic acid) 2,2,6,6-tetramethyl-4-oxaheptane-1,7-diyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ; hydrogen / 1,4-dioxane / 5 h / 230 °C / 63756.4 - 97509.8 Torr / Inert atmosphere 2: toluene-4-sulfonic acid / toluene / 135 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - JP2016/13989, 2016, A

12
[ 7299-86-7 ]
dineopentyl glycol diacrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydrogen; palladium on zirconium oxide / 1,4-dioxane / 5 h / 230 °C / 63756.4 - 97509.8 Torr / Inert atmosphere 2: 4-methoxy-phenol; dimethyltin dichloride; sodium methylate / 26 h / 85 - 105 °C / Heating

Reference： [1]Current Patent Assignee: MITSUBISHI GAS CHEMICAL COMPANY INC - US2017/158855, 2017, A1

13
[ 763-32-6 ]
[ 597-31-9 ]
[ 7299-86-7 ]
2-methyl-2-(4-methylenetetrahydropyran-2-yl)propan-1-ol [ No CAS ]
C₁₀H₂₀O₃ [ No CAS ]
C₁₀H₁₈O₂ [ No CAS ]
C₁₀H₁₈O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With methanesulfonic acid In toluene at 40 - 113℃; for 4h; Dean-Stark;	1.3 Example 3: Synthesis of 2-methyl-2-(4-methylenetetrahydropyran-2-yl)propan-1-ol and its double bond isomers (using methanesulfonic acid as catalyst) A mixture of isoprenol 1 (72.60 g, 0.853 mol) and a 23.6% HPA 2 solution in toluene (750 g, 0.71 mol) was stirred at 40°C. At this temperature, 10 drops of methanesulfonic acid were added to the reaction mixture. The mixture was stirred at reflux (113°C) for 4h while water was being distilled during the reaction. After this time 10 drops of me- thanesulfonic acid were added and the reaction was stirred for 2.5h at reflux, then an other 20 drops of methanesulfonic acid were added. At this point, water started to dis till. The reaction was left at this temperature for 9 more hours. After this time, the reac tion mixture was set to RT. To the mixture 300ml_ of water were added and the organic phase was washed with a 5% solution of NaHCCh and with water. The organic extracts were combined and dried with sodium sulfate and the solvent was removed under re duced pressure. The crude product was subjected to a distillative separation and two major fractions were collected. According to NMR, one of the fractions (fraction 1) proved to be a mixture of two of the elimination products G-1 (55%) and G-3 (20%) and the two acetals II’.1 (15%) and IG.2 (5%). This fraction was used to prepare the propionate in example 8. Also according to NMR, the other fraction (fraction 2) proved to be a mixture of the three elimination products G-1 (30%), G-2 (35%) and G-3 (15%) and the acetal II’.1 (5%). This fraction was used to prepare the methyl ether in example 10. ll‘.1-Isomer: 13C NMR (125 MHz, CDCI3): d = 19.93, 21.68, 22.82, 30.25, 38.95, 69.17, 77.14, 107.57. Il‘.2-Isomer: 13C NMR (125 MHz, CDCI3): d = 19.82, 20.39, 21.44, 31.69, 35.89, 38.68, 63.16, 69.49, 71.67, 101.41.

Reference： [1]Current Patent Assignee: BASF SE - WO2021/122558, 2021, A1 Location in patent: Page/Page column 76-77

Related Products

Historical Records

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 7299-86-7 ]

Quality Control of [ 7299-86-7 ]

Related Doc. of [ 7299-86-7 ]

Product Details of [ 7299-86-7 ]

Calculated chemistry of of [ 7299-86-7 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 7299-86-7 ]

Application In Synthesis of [ 7299-86-7 ]

[ 7299-86-7 ] Synthesis Path-Downstream 1~13

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry