Home Cart 0 Sign in  
X

[ CAS No. 73275-96-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 73275-96-4
Chemical Structure| 73275-96-4
Chemical Structure| 73275-96-4
Structure of 73275-96-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 73275-96-4 ]

Related Doc. of [ 73275-96-4 ]

Alternatived Products of [ 73275-96-4 ]
Product Citations

Product Details of [ 73275-96-4 ]

CAS No. :73275-96-4 MDL No. :MFCD24687675
Formula : C7H5ClO3 Boiling Point : -
Linear Structure Formula :- InChI Key :NIQHATXAPFWWKO-UHFFFAOYSA-N
M.W : 172.57 Pubchem ID :21924862
Synonyms :

Safety of [ 73275-96-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 73275-96-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73275-96-4 ]

[ 73275-96-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 54314-84-0 ]
  • [ 73275-96-4 ]
  • [ 1364686-66-7 ]
YieldReaction ConditionsOperation in experiment
94% To a solution of 5-chloro-2,3-dihydroxy-benzaldehyde (3.1 g, 17.7 mmol) in anhydrous DMSO (20 mL) was added NaH (60percent in mineral oil, 1.50 g, 35.4 mmol) portion-wise and the mixture was stirred for 30 minutes. The solution was cooled to 0 °C and a solution of 3-benzyloxy-l-bromopropane (3.1 mL, 17.7 mmol) in DMSO (3 mL) was added dropwise over 10 minutes period. The ice bath was removed. After overnight, the solution was diluted with EtOAc (100 mL), washed with water, brine, dried over Na2S04, filtered and concentrated under reduced pressure. The product was purified by silica gel column chromatography (2: 1 hexanes-EtOAc mobile phase) generating the title compound (5.3 g, 16.6 mmol, 94percent) as a light yellow oil. 1H NMR (400 MHz, CHLOROFORM-;/) delta ppm 10.81 (s, 1 H), 9.87 (s, 1 H), 7.42 - 7.28 (m, 5 H), 7.17 (s, 1 H), 7.08 (s, 1 H), 4.53 (s, 2 H), 4.17 (t, J=6.2 Hz, 2 H), 3.69 (t, J=5.8 Hz, 2 H), 2.15 (t, J=6.2 Hz, 2 H).
  • 2
  • [ 7740-05-8 ]
  • [ 73275-96-4 ]
YieldReaction ConditionsOperation in experiment
96% With boron tribromide In dichloromethane at 0 - 20℃; 1.O To a solution of 5-chloro-2-hydroxy-3-methoxy-benzaldehyde (7 g, 37.5 mmol) in anhydrous CH2CI2 (200 mL) at 0 °C was added a solution of BBr3 in CH2CI2 (1 M, 93.7 mL, 93.7 mmol) and the reaction mixture was stirred overnight at room temperature. The solution was diluted with CH2CI2 (200 mL), washed with water, brine, dried over Na2S04, filtered and concentrated under reduced pressure generating the title compound (6.2 g, 36.0 mmol, 96%) as a light yellow solid. 1H NMR (400 MHz, CHLOROFORM- ) δ ppm 11.02 (s, 1 H), 9.83 (s, 1 H), 7.18 (s, 1 H), 7.14 (d, J=2.3 Hz, 1 H), 5.71 (s, 1 H).
With boron tribromide In dichloromethane at 0 - 20℃; 34 Weigh compound 34-2 (6.83 g, 36.6 mmol) in dichloromethane (40 mL), Boron tribromide (2M in DCM, 46 mL) was added dropwise through a dropping funnel under ice bath conditions, After the addition was completed, the temperature was raised to room temperature and reacted overnight. After the reaction is over, Pour the system slowly into ice water (100 mL), Stationary layers, collection of organic phases, The aqueous phase was extracted with ethyl acetate (40 mL x 3), Combined organic phases, The organic phase was washed with saturated sodium chloride (50 mL x 2), Dried over anhydrous sodium sulfate, The solvent was distilled off under reduced pressure, The residue containing compound 34-3 was used in the next reaction without further purification.
Recommend Products
Same Skeleton Products
Historical Records