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Chemical Structure| 7362-39-2 Chemical Structure| 7362-39-2

Structure of p-Coumaric Acid Ethyl Ester
CAS No.: 7362-39-2

Chemical Structure| 7362-39-2

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p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties.

Synonyms: Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate

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Product Citations

Chang Min Oh ; Joon Yong Choi ; In Ah Bae ; Hong Taek Kim ; Seong Su Hong ; ay Kyun Noah , et al.

Abstract: Hemp (Cannabis sativa L.) contains a variety of secondary metabolites, including cannabinoids, such as psychoactive (−)-trans-Δ⁹-tetrahydrocannabinol. The present study was conducted to identify the major phenolic components contained in hemp root, which has been relatively under-researched compared to other parts of hemp. The aqueous ethanol extract of hemp roots was fractionated into methylene chloride (MC), ethyl acetate (EA), and water (WT) fractions, and high-performance liquid chromatography with photodiode array detection (HPLC-DAD) analysis was performed. The main ultraviolet (UV)-absorbing phenolic compound contained in the EA fraction was identified as p-coumaric acid by comparing the retention time and UV absorption spectrum with a standard. Silica gel column chromatography was performed to isolate a hydrophobic derivative of p-coumaric acid contained in the MC fraction. Nuclear magnetic resonance (NMR) analysis identified the isolated compound as ethyl p-coumarate. For comparative purposes, ethyl p-coumarate was also chemically synthesized by the esterification reaction of p-coumaric acid. The content of p-coumaric acid and ethyl p-coumarate in the total extract of hemp root was estimated to be 2.61 mg g−1 and 6.47 mg g−1, respectively, by HPLC-DAD analysis. These values correspond to 84 mg Kg−1 dry root and 216 mg Kg−1 dry root, respectively. In conclusion, this study identified p-coumaric acid and ethyl p-coumarate as the main phenolic compounds contained in the hemp roots.

Keywords: hemp root ; Cannabis sativa ; p-coumaric acid ; ethyl p-coumarate ; phenolic compounds

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Product Details of p-Coumaric Acid Ethyl Ester

CAS No. :7362-39-2
Formula : C11H12O3
M.W : 192.21
SMILES Code : CCOC(=O)\C=C\C1=CC=C(O)C=C1
Synonyms :
Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate
MDL No. :MFCD00210460

Safety of p-Coumaric Acid Ethyl Ester

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P261-P305+P351+P338

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.20mL

1.04mL

0.52mL

26.01mL

5.20mL

2.60mL

52.03mL

10.41mL

5.20mL

 

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