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[ CAS No. 741687-07-0 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 741687-07-0
Chemical Structure| 741687-07-0
Structure of 741687-07-0 *Storage: {[proInfo.prStorage]}

Quality Control of [ 741687-07-0 ]

Related Doc. of [ 741687-07-0 ]

SDS

Product Details of [ 741687-07-0 ]

CAS No. :741687-07-0MDL No. :MFCD12408566
Formula : C12H24N2O2 Boiling Point : 300.561°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :228.33Pubchem ID :45095672
Synonyms :

Computed Properties of [ 741687-07-0 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 741687-07-0 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 741687-07-0 ]

  • Downstream synthetic route of [ 741687-07-0 ]

[ 741687-07-0 ] Synthesis Path-Downstream   1~10

  • 1
  • 4-ethyl-4-isocyanato-piperidine-1-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]
  • [ 741687-07-0 ]
YieldReaction ConditionsOperation in experiment
With potassium trimethylsilonate; In tetrahydrofuran; at 18 - 25℃; for 18h; Step B. To a solution of the above solid from step A (3.28g) in THF (50ml) was addedpotassium trimethylsilanolate (3.68g) and the resulting mixture was stirred at roomtemperature for 18 hours. The reaction mixture was partitioned between dichloromethane andsaturated sodium bicarbonate. The organic extracts were dried (MgSO4) and evaporated todryness to give the sub-title compound (2.42g) as an orange oil which was used withoutfurther purification. NMR(d6 DMSO): 0.75 (t, 3H), 1.1-1.4 (m, 6H), 1.3 (s, 9H), 3.1 (m, 2H),3.45(m,2H).
  • 2
  • [ 91419-52-2 ]
  • [ 741687-07-0 ]
  • 3
  • [ 5798-75-4 ]
  • [ 741687-07-0 ]
  • C21H32N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos; In toluene; at 100℃; A. solution of the compound 4 (1.0 g, 4.4 mmoi). ethyl 4-bromobenzoar.e (943 nig, 4.4 mmol), Pd2(dba)3 (202 mg, 0.22 mmol), Ruphos (103 mg, 0.22 nunol) arid Cs2CO3 (2.9 g, 8.8 inmol) in toluene (25 in) was stirred at 100C overnight. The mixture was concentrated and purified by silica gel column with EA:PE = 1:5 to affbrd compound 5 (1.0 g, 59%) as a light yellow solid.
  • 4
  • [ 741687-07-0 ]
  • C29H35N5O3S [ No CAS ]
  • 5
  • [ 741687-07-0 ]
  • C24H28N4OS*ClH [ No CAS ]
  • 6
  • [ 741687-07-0 ]
  • C34H44N4O5S [ No CAS ]
  • 7
  • [ 741687-07-0 ]
  • C19H28N2O4 [ No CAS ]
  • 8
  • [ 741687-07-0 ]
  • C29H36N6O2S [ No CAS ]
  • 9
  • [ 741687-07-0 ]
  • C34H44N6O4S [ No CAS ]
  • 10
  • C13H24N2O3 [ No CAS ]
  • [ 741687-07-0 ]
YieldReaction ConditionsOperation in experiment
55% With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium hydroxide; In acetonitrile; at 20℃; To a solution of the compound 3 (20.5 g, 80 rnmoi) in CH3CN (200 ml) and 5N KOH (10() nil) was added i,3-dibromo-5,5-dimethylimidazohdine-2,4-diorie (11.1 g, 40nunol). The mixture was stirred overnight at room temperature. Afier completion, the mixture was concentrated to remove CH3CN. Adjustment of the pH of the water phase to 5 was with 2N HC1 in ice bath, the mixture was extracted with EA and separated i1en adjustment of the pH of water phase to 10. The precipitate was collected to afford the compound 4 (10 g, 55%) as a white solid.
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