Alternatived Products of [ 74443-00-8 ]
Product Details of [ 74443-00-8 ]
CAS No. : | 74443-00-8 |
MDL No. : | MFCD27979283 |
Formula : |
C9H8N2O3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | VQGMRETZBGIACU-UHFFFAOYSA-N |
M.W : | 192.17 |
Pubchem ID : | 12631995 |
Synonyms : |
|
Application In Synthesis of [ 74443-00-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 74443-00-8 ]
- 1
-
amino 2-cyanoacetate
[ No CAS ]

-
[ 141-52-6 ]

-
[ 4869-46-9 ]

-
[ 74443-00-8 ]
- 2
-
[ 4869-46-9 ]

-
[ 107-91-5 ]

-
[ 74443-00-8 ]
- 3
-
[ 4869-46-9 ]

-
[ 74443-00-8 ]
- 4
-
[ 74443-00-8 ]

-
[ 856165-97-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
Stage #1: ethyl 5-cyano-6-hydroxynicotinate With thionyl chloride; N,N-dimethyl-formamide Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate |
22.B
Step B: Ethyl 6-chloro-5-cyanonicotinate; To a solution of 222 mg (1.16 mmol) of ethyl 5-cyano-6-hydroxynicotinate (from Step A) in 5 mL of SOC12 was added 500 IIL of DMF. After refluxing overnight, the mixture was cooled to rt and concentrated. The residue was dissolved in EtOAc (20 mL) and washed with brine (10 mL), saturated NaHCO3 (10 mL), and brine (10 mL), dried over Na2S04, and concentrated. Chromatography on a Biotage 40M cartridge using 1: 9 v/v EtOAc/hexanes gave 145 mg of the title compound :'H NMR (500 MHz, CDC13) 8 1.44 (d, J = 7.1, 3H), 4.46 (q, J = 7.1, 2H), 8. 58 (d, J = 2. 1, 1H), 9.15 (d, J = 2. 1, 1H). |