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[ CAS No. 74443-00-8 ]

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3d Animation Molecule Structure of 74443-00-8
Chemical Structure| 74443-00-8
Chemical Structure| 74443-00-8
Structure of 74443-00-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 74443-00-8 ]

CAS No. :74443-00-8 MDL No. :MFCD27979283
Formula : C9H8N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :VQGMRETZBGIACU-UHFFFAOYSA-N
M.W :192.17 Pubchem ID :12631995
Synonyms :

Safety of [ 74443-00-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P270-P301+P312-P330-P501 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 74443-00-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74443-00-8 ]

[ 74443-00-8 ] Synthesis Path-Downstream   1~4

  • 1
  • amino 2-cyanoacetate [ No CAS ]
  • [ 141-52-6 ]
  • [ 4869-46-9 ]
  • [ 74443-00-8 ]
  • 2
  • [ 4869-46-9 ]
  • [ 107-91-5 ]
  • [ 74443-00-8 ]
  • 3
  • [ 4869-46-9 ]
  • [ 74443-00-8 ]
  • 4
  • [ 74443-00-8 ]
  • [ 856165-97-4 ]
YieldReaction ConditionsOperation in experiment
Stage #1: ethyl 5-cyano-6-hydroxynicotinate With thionyl chloride; N,N-dimethyl-formamide Heating / reflux; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate 22.B Step B: Ethyl 6-chloro-5-cyanonicotinate; To a solution of 222 mg (1.16 mmol) of ethyl 5-cyano-6-hydroxynicotinate (from Step A) in 5 mL of SOC12 was added 500 IIL of DMF. After refluxing overnight, the mixture was cooled to rt and concentrated. The residue was dissolved in EtOAc (20 mL) and washed with brine (10 mL), saturated NaHCO3 (10 mL), and brine (10 mL), dried over Na2S04, and concentrated. Chromatography on a Biotage 40M cartridge using 1: 9 v/v EtOAc/hexanes gave 145 mg of the title compound :'H NMR (500 MHz, CDC13) 8 1.44 (d, J = 7.1, 3H), 4.46 (q, J = 7.1, 2H), 8. 58 (d, J = 2. 1, 1H), 9.15 (d, J = 2. 1, 1H).
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