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Chemical Structure| 7512-17-6 Chemical Structure| 7512-17-6

Structure of N-Acetyl-D-glucosamine
CAS No.: 7512-17-6

Chemical Structure| 7512-17-6

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N-Acetylglucosamine is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases.

Synonyms: N-Acetyl-2-amino-2-deoxy-D-glucose; GlcNAc; NSC 400525

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Product Citations

Product Citations

Tan, Junjun ; Liu, Qiong ; Liu, Zhiping ; Cao, Yanli ; Yu, Xiaomin ; Zhao, Qianjun , et al.

Abstract: Small heat shock proteins are evolutionarily conserved molecular chaperones with diverse cellular roles. However, our understanding of their functions in pathogenic microorganisms remains limited. In this study, we identified and characterized Fmp28, a novel small heat shock protein that enhances virulence in Candida albicans, and explored its regulatory mechanism. The expression of Fmp28 was significantly upregulated at both transcriptional and translational levels when C. albicans was subjected to physiological temperature (37°C), osmotic stress, or cell wall stress. Deletion of Fmp28 significantly impaired growth, adhesion, biofilm formation, invasive growth, and virulence at physiological temperature (37°C), respectively. Transcriptome analysis identified Als3 as a key downstream target of Fmp28. Notably, Als3 overexpression substantially rescued the impairments in adhesion, biofilm formation, invasion, and virulence caused by FMP28 deletion. Deletion of FMP28 also led to downregulated expression of genes in the cAMP-PKA pathway, as well as reduced intracellular ATP and cAMP levels. By adding exogenous cAMP analogs, the adhesion and biofilm formation in the fmp28Δ/Δ mutant could be partially restored. In conclusion, the findings in this study demonstrated that Fmp28 maintained C. albicans virulence at physiological temperature by regulating Als3 expression through the cAMP-PKA signaling pathway, establishing Fmp28 as a potential therapeutic target for treating C. albicans infections.

Keywords: small heat shock protein ; Fmp28 ; Candida albicans ; Als3 ; virulence

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Product Details of N-Acetyl-D-glucosamine

CAS No. :7512-17-6
Formula : C8H15NO6
M.W : 221.21
SMILES Code : O=C[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O)O)O
Synonyms :
N-Acetyl-2-amino-2-deoxy-D-glucose; GlcNAc; NSC 400525
MDL No. :MFCD00136044
InChI Key :MBLBDJOUHNCFQT-LXGUWJNJSA-N
Pubchem ID :1738118

Safety of N-Acetyl-D-glucosamine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.52mL

0.90mL

0.45mL

22.60mL

4.52mL

2.26mL

45.21mL

9.04mL

4.52mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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