[ CAS No. 758699-74-0 ] {[proInfo.proName]}

Name: 758699-74-0|4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|98%
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Quality Control of [ 758699-74-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 758699-74-0 ]

Product Details of [ 758699-74-0 ]

CAS No. :	758699-74-0	MDL No. :	MFCD07367561
Formula :	C₁₂H₁₈BNO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FVHUFNSLTSKBDN-UHFFFAOYSA-N
M.W :	235.09	Pubchem ID :	44118676
Synonyms :

Safety of [ 758699-74-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 758699-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 758699-74-0 ]

[ 758699-74-0 ] Synthesis Path-Downstream 1~4

1
[ 758699-74-0 ]
tert-butyl rac-exo-[6-(2-bromophenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate [ No CAS ]
tert-butyl rac-exo-[6-(2-(4-methoxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 4749 - 4752

2
[ 758699-74-0 ]
[ 1403396-20-2 ]
[ 1403396-68-8 ]

Yield	Reaction Conditions	Operation in experiment
63%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; at 130.0℃; for 1.5h;Microwave irradiation;	A solution of the compound (508 mg, 1.0 mmol) obtained in Example 16-4), <strong>[758699-74-0]4-methoxypyridine-3-boronic acid pinacol ester</strong> (321 mg, 1.5 mmol), tetrakis(triphenylphosphine)palladium(0) (231 mg, 0.2 mmol), and potassium carbonate (276 mg, 2 mmol) in dimethoxyethane (4 mL) and water (1 mL) was stirred at 130C for 1.5 h under microwave irradiation. The reaction mixture was cooled to room temperature, saturated aqueous sodium hydrogencarbonate was added to the reaction mixture, the mixture was extracted with dichloromethane, and the organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (Isco Combiflash, 40 g, methanol:ethyl acetate = 0:100 to 20:80, gradient) to obtain the title compound (337 mg, 63%) as a colorless solid. 1H-NMR (400 MHz, CDCl3) delta: 0.05 (3H, s), 0.07 (3H, s), 0.91 (9H, s), 1.20 (3H, s), 1.44-1.60 (2H, m), 1.62-1.69 (2H, m), 2.57 (1H, ddd, J = 15.5, 8.1, 2.2 Hz), 2.71 (1H, ddd, J = 15.5, 7.9, 2.1 Hz), 3.40 (2H, s), 3.51 (1H, d, J = 10.2 Hz), 3.55 (1H, d, J = 10.2 Hz), 3.87 (3H, s), 4.10 (1H, ddd, J = 14.5, 7.9, 2.1 Hz), 4.35 (1H, ddd, J = 14.5, 8.1, 2.2 Hz), 6.90 (1H, dd, J = 11.5, 5.9 Hz), 7.14 (2H, d, J = 8.6 Hz), 7.44 (2H, d, J = 8.6 Hz), 7.52 (1H, d, J = 3.1 Hz), 8.48 (1H, dd, J = 11.5, 5.9 Hz)

Reference： [1]Patent: EP2700643,2014,A1 .Location in patent: Paragraph 0327

3
[ 79762-54-2 ]
[ 758699-74-0 ]
6-(4-methoxypyridin-3-yl)-1H-indazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium carbonate; In 1,4-dioxane; water; at 110.0℃;	A mixture of 6-bromo-lH-indazole (500 mg, 2.54 mmol), 4-methoxy-3-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)pyridine (895 mg, 3.81 mmol), Pd(dppf)C12 (414 mg, 0.51 mmol) and K2C03 (701 mg, 5.08 mmol) in dioxane (10 mL) and water (0.5 mL) was heated tol lO C and stirred overnight. The filtration removed the solid. After washing with DCM, the combined filtrate was concentrated in vacuo. The residue was purified by ISCO flash chromatography (eluted with 0-100% EtOAc / hexane) to provide 6-(4-methoxypyridin-3-yl)-lH-indazole.

Reference： [1]Patent: WO2016/36586,2016,A1 .Location in patent: Page/Page column 40; 41

4
[ 79762-54-2 ]
[ 758699-74-0 ]
4-(4-(6-(4-methoxypyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)morpholine [ No CAS ]

Reference： [1]Patent: WO2016/36586,2016,A1

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[ 758699-74-0 ]

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Related Parent Nucleus of
[ 758699-74-0 ]

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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
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P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P370 + P378	In case of fire:
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
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H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H226	Flammable liquid and vapour
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
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H261	In contact with water releases flammable gas
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
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H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 758699-74-0 ] {[proInfo.proName]}

Quality Control of [ 758699-74-0 ]

Related Doc. of [ 758699-74-0 ]

Product Details of [ 758699-74-0 ]

Safety of [ 758699-74-0 ]

Application In Synthesis of [ 758699-74-0 ]

[ 758699-74-0 ] Synthesis Path-Downstream 1~4

Related Functional Groups of [ 758699-74-0 ]

Organoboron

Ethers

Related Parent Nucleus of [ 758699-74-0 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 758699-74-0 ]

Related Parent Nucleus of
[ 758699-74-0 ]