Home Cart Sign in  
Chemical Structure| 76547-98-3 Chemical Structure| 76547-98-3

Structure of Lisinopril
CAS No.: 76547-98-3

Chemical Structure| 76547-98-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Lisinopril is angiotensin-converting enzyme inhibitor that blocks the formation of angiotensin I with an IC50 value of 1.2 nM (ovine) and displays ID50 values of 2.3 and 6.5 µg/kg in rat and canine, respectively. It is used in treatment of hypertension, congestive heart failure, and heart attacks.

Synonyms: MK-521; MK-522

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Roth, Lukas ; Gotsbacher, Michael P. ; Codd, Rachel ;

Abstract: Immobilized metal-ion affinity chromatog. (IMAC) used to purify recombinant proteins features a resin-bound 1:1 Ni(II)-iminodiacetic acid (IDA) complex. This hemi-saturated Ni(II)-IDA system containing exchangeable sites at the metal ion is re-cast as a surrogate of a coordinatively-unsaturated metalloenzyme active site, with utility for selecting compounds with metal-binding groups from mixtures as potential metalloenzyme inhibitors. Exchanging Ni(II) for other metal ions could broaden the scope of metalloenzyme target. This work examined the performance of Cu(II)-, Fe(III)-, Ga(III)-, Ni(II)-, or Zn(II)-IMAC resins to reversibly bind exptl. or clin. metalloenzyme inhibitors of Zn(II)-ACE1, Zn(II)-HDAC, Fe(II)/(III)-5-LO or Cu(II)-tyrosinase from a curated mixture (1-17). Each IMAC system gave a distinct selection profile. The Zn(II)-IMAC system selectively bound the thiol-containing Zn(II)-ACE1 inhibitors captopril and omapatrilat, and the Fe(III)-IMAC system selectively bound the Fe(II)/(III)-5-LO inhibitor licofelone, demonstrating a remarkable IMAC-metalloenzyme metal ion match. IMAC provides a simple, water-compatible platform, which could accelerate metalloenzyme inhibitor discovery.

Purchased from AmBeed: ; ; ; 76420-72-9 ;

Alternative Products

Product Details of Lisinopril

CAS No. :76547-98-3
Formula : C21H31N3O5
M.W : 405.49
SMILES Code : O=C([C@H]1N(CCC1)C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(O)=O)CCCCN)=O)O
Synonyms :
MK-521; MK-522
MDL No. :MFCD00214086

Safety of Lisinopril

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H361-H373
Precautionary Statements:P201-P202-P260-P280-P308+P313-P405-P501

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00567307 Cardiovascular Disease Phase 2 Completed - Sri Lanka ... More >> The National Hospital of Sri Lanka Colombo, Sri Lanka, Colombo10 Teaching (General) Hospital Kandy Kandy, Sri Lanka Teaching (General) Hospital Kegalle Kegalle, Sri Lanka Less <<
NCT00292162 Chronic Heart Failure ... More >> Atrial Fibrillation Less << Not Applicable Completed - United Kingdom ... More >> Glasgow Royal Infirmary Glasgow, Scotland, United Kingdom, G31 2ER Less <<
NCT03461003 Pediatric Hypertension Phase 4 Recruiting January 2020 United States, Texas ... More >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joyce P Samuel, MD, MS    713-500-5670    joyce.p.samuel@uth.tmc.edu Less <<
NCT00123903 Heart Failure, Congestive and ... More >>Microalbuminuria Less << Phase 3 Terminated - -
NCT01774656 Heart Failure NYHA Class III ... More >> Heart Failure NYHA Class IV Less << Phase 4 Recruiting December 2017 United States, Kentucky ... More >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Terry Blanton, BSN, RN       mtblan02@louisville.edu    Principal Investigator: Emma Birks, MD, PhD          United States, Nebraska University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Stacy Flickbohm, RN    402-559-5127    stacy.fickbohm@unmc.edu    Contact: Natalie Kamtz    402-559-3293    natalie.kamtz@unmc.edu    Principal Investigator: Brian D Lowes, MD, PhD          United States, New York Montefiore Medical Center Recruiting New York, New York, United States, 10467 Contact: Auris Brown       aubrowne@montefiore.org    Contact: Johanna Oviedo    718-920-8780    joviedo@montefiore.org    Principal Investigator: Snehal Patel, MD          United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Barb Gus, RN BSN CCRC    216-445-6552    GUSB@ccf.org    Principal Investigator: Maria Mountis, D.O.          United States, Pennsylvania University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19140 Contact: Judith Marble       Judith.Marble@uphs.upenn.edu    Principal Investigator: J E Rame, MD          United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Ashley Elmer       ashley.elmer@hsc.utah.edu    Principal Investigator: Craig Selzman, MD Less <<
NCT02774460 Hypertension Phase 4 Not yet recruiting November 2020 Sweden ... More >> Uppsala University hospital, Internal medicine research, Oscar II Not yet recruiting Uppsala, Sweden, SE-752 37 Contact: Kerstin Marttala, Study nurse    004618-6113632    kerstin.marttala@akademiska.se    Principal Investigator: Johan Sundstrom, Professor Less <<
NCT01901549 Acute Coronary Syndrome ... More >> Arterial Hypertension Less << Phase 2 Unknown June 2016 Russian Federation ... More >> State Research Institute of Circulation Pathology Recruiting Novosibirsk, Russian Federation, 630055 Contact: Evgeny Pokushalov, MD, PhD    +79139254858    E.Pokushalov@gmail.com    Principal Investigator: Evgeny Pokushalov, MD, PhD          Sub-Investigator: Alexander Romanov, MD          Sub-Investigator: Alexander Osiev, MD PhD          Sub-Investigator: Igor Grazhdankin, MD Less <<
NCT01575652 Disorders Associated With Peri... More >>toneal Dialysis Less << Phase 4 Completed - -
NCT00567307 - Completed - -
NCT02232880 Hypertension Phase 2 Terminated(failure to recruit) - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-6602 Less <<
NCT02232880 - Terminated(failure to recruit) - -
NCT00292162 - Completed - -
NCT00605072 - Completed - -
NCT00283686 - Completed - -
NCT00605072 Cognitive Impairment ... More >> Hypertension Aging Less << Phase 2 Completed - United States, California ... More >> University of Southern California Los Angeles, California, United States, 90033 United States, Massachusetts Hebrew SeniorLife Boston, Massachusetts, United States, 02131 Less <<
NCT00994253 Hypertension ... More >>Diabetes Type 2 Less << Phase 4 Withdrawn(Due to safety concer... More >>ns re the concomitant use of aliskiren with an ACEi or ARB.) Less << December 2012 United States, Michigan ... More >> William Beaumont Hospital Royal Oak, Michigan, United States, 48073 Less <<
NCT00283686 Kidney, Polycystic Phase 3 Completed - United States, Colorado ... More >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Less <<
NCT00171535 Hypertension Phase 3 Completed - United States, New Jersey ... More >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Less <<
NCT00555217 Kidney Disease ... More >> Nephropathy Type 2 Diabetes Less << Phase 3 Terminated(It was stopped prim... More >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Less << - -
NCT02412761 Essential Hypertension Not Applicable Completed - United States, Texas ... More >> University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics Houston, Texas, United States, 77030 Less <<
NCT01837069 Osteoarthritis ... More >> Cardiovascular Disease Less << Phase 4 Suspended(Low recruitment / DS... More >>MB approval to halt recruitment) Less << December 2018 United States, New York ... More >> NYU Hospital for Joint Diseases New York, New York, United States, 10003 Less <<
NCT00555217 - Terminated(It was stopped prim... More >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Less << - -
NCT01437371 Heart Failure Phase 3 Completed - France ... More >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Less <<
NCT02412761 - Completed - -
NCT00006294 - Completed - United States, Kentucky ... More >> University of Kentucky Lexington, Kentucky, United States, 40536 Less <<
NCT01313702 Cardiovascular Disease Phase 3 Unknown July 2014 Brazil ... More >> Instituto de Ensino e Pesquisa - IEP - HCor Not yet recruiting Sao Paulo, Brazil, 04005-000 Contact: Otavio Berwanger, PhD    +55 11 30536611 ext 8203    oberwanger@hcor.com.br    Principal Investigator: Otavio Berwanger, PhD Less <<
NCT02847338 Hypertension Phase 4 Recruiting November 2021 United Kingdom ... More >> Cambridge University Hospitals NHS Foundation Trust Recruiting Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Contact: Ella James    01223 349762       Principal Investigator: Joseph Cheriyan          Queen Elizabeth Hospital Recruiting Birmingham, United Kingdom, B15 2TH Principal Investigator: Una Martin          Sandwell & West Birmingham Hospitals NHS Trust Recruiting Birmingham, United Kingdom, B18 7QH Contact: Ronnie HAYNES    0121 507 5113    ronnie.haynes@nhs.net    Contact: Rebecca Brown    0121 507 6657    Rebecca.brown15@nhs.net    Principal Investigator: Gregory Lip          University Hospital Llandough Recruiting Cardiff, United Kingdom, CF64 2XX Contact: Maggie Munnery    029 20416278    MMunnery@cardiffmet.ac.uk    Contact: Barry McDonnell    029 206827    bmcdonnell@cardiffmet.ac.uk    Principal Investigator: James Coulson          University of Glasgow Recruiting Glasgow, United Kingdom, G12 8TA Principal Investigator: Sandosh Padmanabhan          Leicester General Hospital Not yet recruiting Leicester, United Kingdom, LE5 4PW Principal Investigator: Kamlesh Khunti          William Harvey Research Institute, Barts and the London Medical School Recruiting London, United Kingdom, EC1M 6BQ Principal Investigator: David Collier          St. Thomas Hospital Recruiting London, United Kingdom, SE1 7EH Principal Investigator: Phil Chowienczyk          Sub-Investigator: Luca Faconti          Imperial College Healthcare NHS Trust St. Marys Hospital Not yet recruiting London, United Kingdom, W2 1NY Principal Investigator: Simon Thom          University College London Not yet recruiting London, United Kingdom, WC1E 7HB Principal Investigator: Alun Hughes          Manchester Royal Infirmary Recruiting Manchester, United Kingdom, M13 9WL Principal Investigator: Tony Heagerty          Newcastle Hospital NHS Foundation Trust Not yet recruiting Newcastle, United Kingdom, NE2 4HH Principal Investigator: Simon Thomas Less <<
NCT00874432 Cardiovascular Disease ... More >> Chronic Kidney Disease Less << Not Applicable Completed - United States, Wisconsin ... More >> University of Wisconsin-Madison Hospitals and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT00151138 Hypertension Not Applicable Completed - United States, Pennsylvania ... More >> Dept of Psychiatry, University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00814255 - Completed - -
NCT02603809 Essential Hypertension Phase 2 Completed - -
NCT02641899 Healthy Phase 1 Completed - United States, Kansas ... More >> Quintiles Overland Park, Kansas, United States, 66211 Less <<
NCT00814255 Focal Segmental Glomeruloscler... More >>osis Less << Phase 2 Completed - United States, Florida ... More >> University of Miami Miami, Florida, United States, 33136 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55901 United States, Missouri Children's Mercy Hospital Kansas City, Missouri, United States, 64108 Cardinal Glennon Children's Medical Center Saint Louis, Missouri, United States, 63104 United States, New York Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040 NYU Langone Medical Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States, 28207 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Ohio State University Columbus, Ohio, United States, 43205 United States, Oregon Doernbecher Children's Hospital Portland, Oregon, United States, 97239 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Texas Tech University El Paso, Texas, United States, 79905 Canada, Alberta University of Alberta Edmonton, Alberta, Canada, T6G 2R7 Less <<
NCT03195023 Renal Insufficiency, Chronic ... More >> Proteinuria Less << Phase 4 Recruiting June 2021 Spain ... More >> Gregorio Maranon Hospital Recruiting Madrid, Spain, 28007 Contact: Maria Angeles Goicoechea, PhD, MD    0034609838684    marian.goicoechea@gmail.com    Contact: Ana María García, MD    0034676611045    anamgarciaprieto@gmail.com Less <<
NCT01535235 HIV Phase 4 Completed - United States, California ... More >> San Francisco General Hospital San Francisco, California, United States, 94110 Less <<
NCT01535235 - Completed - -
NCT00280215 Hyperoxaluria Phase 3 Withdrawn(Inadequate number of... More >> patients, lack of funding) Less << - -
NCT03422705 Pacemakers, Heart Failure Phase 2 Not yet recruiting September 1, 2021 -
NCT01885559 Kidney, Polycystic Phase 3 Completed - United States, Colorado ... More >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Less <<
NCT00219167 Hypertension Phase 3 Completed - Switzerland ... More >> Novartis Pharmaceuticals Basel, Switzerland Less <<
NCT02358642 Pneumonia Neu... More >>rological Dysphagia Less << Phase 4 Terminated(The interim analysi... More >>s suggested that low dose lisinopril given to be tube fed older patients with neuroligical dysphagia had increased mortality.) Less << - Hong Kong ... More >> Prince of Wales Hospital Hong Kong, Hong Kong Less <<
NCT00004266 Diabetic Nephropathy Phase 3 Completed - United States, Minnesota ... More >> Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415 Less <<
NCT00982189 HIV Infection ... More >> Cardiovascular Disease Risk Less << Not Applicable Completed - United States, Minnesota ... More >> Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415 Less <<
NCT01506505 Cardiovascular Disease ... More >> Cerebrovascular Disease Peripheral Arterial Disease Less << Not Applicable Completed - Netherlands ... More >> UMC Utrecht Utrecht, Netherlands, 3508 GA Less <<
NCT01885559 - Completed - -
NCT00118976 Diabetes Mellitus, Type I ... More >> Diabetic Nephropathy Less << Not Applicable Completed - Denmark ... More >> Steno Diabetes Center Gentofte, Denmark, 2820 Less <<
NCT03201939 HIV/AIDS Albu... More >>minuria Kidney Diseases Genetic Predisposition Less << Phase 2 Recruiting August 31, 2022 Nigeria ... More >> Aminu Kano Teaching Hospital Recruiting Kano, Nigeria Contact: Baba M Musa, MBBS, MPH    +234-803-347-2311    babamaiyaki2000@yahoo.co.uk    Contact: Faisal S. Danikshiya, MBBS    234-806-129-7871    fdankishiya@yahoo.com Less <<
NCT00982189 - Completed - -
NCT00837590 Pre-diabetes ... More >>Obesity Less << Not Applicable Completed - United States, Indiana ... More >> Indiana Clinical Research Center Indianapolis, Indiana, United States, 46202 Less <<
NCT00657241 Hypertension Phase 3 Completed - United States, New York ... More >> Erie County Medical Center Buffalo, New York, United States, 14215 Less <<
NCT01518166 Diabetes Heal... More >>thy Less << Phase 1 Completed - Sweden ... More >> Novo Nordisk Investigational Site Uppsala, Sweden, 75323 Less <<
NCT00108082 Hypertrophy, Left Ventricular Phase 3 Completed - -
NCT02441842 Perioperative Hypertension Phase 4 Completed - -
NCT02682459 Extracapillary Glomerulonephri... More >>tis Less << Phase 2 Recruiting December 2019 Italy ... More >> Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò Recruiting Ranica, Bergamo, Italy, 24020 Sub-Investigator: Barbara Ruggiero, MD          ASST Papa Giovanni XXIII Recruiting Bergamo, Italy, 24147 Principal Investigator: Giuseppe Remuzzi, MD          Sub-Investigator: Ettore Sabadini, MD          Sub-Investigator: Piero Ruggenenti, MD Less <<
NCT00108082 - Completed - -
NCT00582114 Hemodialysis ... More >>Hypertension Left Ventricular Hypertrophy Less << Phase 3 Terminated(Stopped by data saf... More >>ety monitoring board) Less << - United States, Indiana ... More >> Indiana University Indianapolis, Indiana, United States, 46202 Less <<
NCT00537043 Hypertension Phase 1 Completed - United States, New Jersey ... More >> GSK Investigational Site Hackensack, New Jersey, United States, 07601 United States, Texas GSK Investigational Site Austin, Texas, United States, 78704 Less <<
NCT00582114 - Terminated(Stopped by data saf... More >>ety monitoring board) Less << - -
NCT01234922 - Terminated(slow accrual) - -
NCT02336607 Hypertension Not Applicable Completed - -
NCT01234922 Hypertension ... More >>Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 2 Terminated(slow accrual) - United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less <<
NCT00311870 Diabetic Nephropathy Phase 4 Completed - Denmark ... More >> Steno Diabetes Center Gentofte, Denmark, DK-2820 Less <<
NCT00219050 Hypertension Phase 3 Completed - Germany ... More >> Investigative Site Berlin, Germany Hungary Investigative Site Budapest, Hungary Spain Investigative Site Madrid, Spain Switzerland Novartis Pharmaceuticals Basel, Switzerland Less <<
NCT00773084 Diastolic Heart Failure Not Applicable Withdrawn(Difficulty in recrui... More >>ting patients and then the PI left the institution) Less << August 2009 United States, Texas ... More >> Texas Tech University Health Sciences Center Lubbock, Texas, United States, 79430 Less <<
NCT00430040 Diabetes Mellitus, Type 2 ... More >> Hypertension Less << Phase 4 Unknown May 2013 United States, New York ... More >> Diabetes - Endocrinology Center of Western New York Buffalo, New York, United States, 14221 Less <<
NCT02336607 - Completed - -
NCT01181284 - Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01691781 - Completed - -
NCT01009944 Hypertension Not Applicable Active, not recruiting March 2018 United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less <<
NCT00556920 Hypertension Phase 1 Completed - United States, New York ... More >> GSK Investigational Site Buffalo, New York, United States, 14202 Less <<
NCT01691781 Hyperparathyroidism Not Applicable Completed - United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less <<
NCT02369926 Multiple Sclerosis, Relapsing-... More >>Remitting Less << Phase 2 Recruiting - United States, New York ... More >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Tarah Gustafson       tarah.gustafson@mssm.edu    Principal Investigator: Fred Lublin, MD Less <<
NCT00241124 Hypertension Phase 4 Completed - Germany ... More >> Investigative Centers, Germany Less <<
NCT01324388 Diabetes Mellitus, Type 2 Phase 1 Completed - United States, Hawaii ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Honolulu, Hawaii, United States, 96813 United States, Indiana For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Evansville, Indiana, United States, 47710 United States, Texas For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dallas, Texas, United States, 75247 Less <<
NCT00337298 Type 1 Diabetes ... More >> Diabetic Retinopathy Eye Diseases Diabetes Complications Less << Not Applicable Completed - Denmark ... More >> Aarhus university hospital Aarhus, Denmark, 8000 Less <<
NCT00171574 Hypertension ... More >>Diabetic Nephropathy Less << Phase 4 Completed - Switzerland ... More >> Novartis Pharmaceuticals Basel, Switzerland Less <<
NCT01324388 - Completed - -
NCT00549510 Hypertension Phase 1 Completed - United States, Texas ... More >> GSK Investigational Site Austin, Texas, United States, 78744 Less <<
NCT00557128 Hypertension Phase 1 Completed - United States, Texas ... More >> GSK Investigational Site Austin, Texas, United States, 78744 Less <<
NCT00553969 - Completed - -
NCT00553969 Pre-hypertension Phase 1 Phase 2 Completed - United States, Minnesota ... More >> University of Minnesota, Variety Club Research Center 102 Minneapolis, Minnesota, United States, 55455 Less <<
NCT02623036 Hypertension, Resistant to Con... More >>ventional Therapy Less << Phase 1 Recruiting April 2018 United States, Georgia ... More >> Memorial Family Medicine Center Recruiting Savannah, Georgia, United States, 31404 Contact: John Bucheit, Pharm.D.    312-350-8404    bucheit_jd@mercer.edu    Principal Investigator: John Bucheit, Pharm.D.          Sub-Investigator: Cindy Gleit, M.D.          Sub-Investigator: Kathryn Momary, Pharm.D.          Sub-Investigator: Angela Kaylor, R.N.          Sub-Investigator: Daniel Gordon, M.D. Less <<
NCT01398267 Diabetes Mellitus Type 2 Phase 1 Completed - United States, California ... More >> Chula Vista, California, United States, 91911 United States, Nebraska Omaha, Nebraska, United States, 68154 United States, Texas Dallas, Texas, United States, 75247 San Antonio, Texas, United States, 78209 Less <<
NCT01101269 Type 2 Diabetes Not Applicable Terminated(Slow Recruitment) - United States, Virginia ... More >> University of Virginia Health System Charlottesville, Virginia, United States, 22908 Less <<
NCT00734630 Hypertension Phase 4 Completed - -
NCT01218100 - Completed - -
NCT00171600 Hypertension ... More >>Early Diabetic Nephropathy Less << Phase 4 Terminated - Switzerland ... More >> Novartis Pharmaceuticals Basel, Switzerland Less <<
NCT01218100 Stage 2 Diastolic Hypertension Phase 4 Completed - -
NCT00883506 Hypertension Phase 1 Completed - -
NCT00171067 Hypertension Phase 3 Completed - Germany ... More >> Investigative Centers, Germany Switzerland Novartis Pharmaceuticals Basel, Switzerland Less <<
NCT00734630 - Completed - -
NCT00508365 Hypertension Phase 1 Completed - United States, Alabama ... More >> GSK Investigational Site Anniston, Alabama, United States, 36207 United States, Arizona GSK Investigational Site Glendale, Arizona, United States, 85308 United States, California GSK Investigational Site Anaheim, California, United States, 92801 GSK Investigational Site Beverly Hills, California, United States, 90211 GSK Investigational Site Long Beach, California, United States, 90806 United States, Florida GSK Investigational Site Coral Gables, Florida, United States, 33134 GSK Investigational Site Miami, Florida, United States, 33169 GSK Investigational Site Sarasota, Florida, United States, 34239 GSK Investigational Site West Palm Beach, Florida, United States, 33409 United States, Idaho GSK Investigational Site Boise, Idaho, United States, 83704 United States, Indiana GSK Investigational Site Indianapolis, Indiana, United States, 46260 United States, Nevada GSK Investigational Site Las Vegas, Nevada, United States, 89119 United States, New Jersey GSK Investigational Site Hackensack, New Jersey, United States, 07601 United States, North Dakota GSK Investigational Site Fargo, North Dakota, United States, 58103 United States, Ohio GSK Investigational Site Cleveland, Ohio, United States, 44122 United States, Oklahoma GSK Investigational Site Oklahoma City, Oklahoma, United States, 73132 United States, Oregon GSK Investigational Site Portland, Oregon, United States, 97239 United States, Texas GSK Investigational Site Austin, Texas, United States, 78704 GSK Investigational Site Houston, Texas, United States, 77081 GSK Investigational Site San Antonio, Texas, United States, 78229 Less <<
NCT00883064 Hypertension Phase 1 Completed - -
NCT00552708 Hypertension Phase 1 Completed - United States, Washington ... More >> GSK Investigational Site Tacoma, Washington, United States, 98418 Less <<
NCT02070510 Diabetes Heal... More >>thy Less << Phase 1 Completed - Germany ... More >> Berlin, Germany, 14050 Less <<
NCT01126697 Duchenne Muscular Dystrophy ... More >> Becker Muscular Dystrophy Limb Girdle Muscular Dystrophy Less << Phase 2 Phase 3 Completed - United States, District of Col... More >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital Chicago, Illinois, United States United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee University of Tennessee Memphis, Tennessee, United States Canada, Alberta Alberta Children's Hospital Calgary, Alberta, Canada Japan National Center of Neurology and Psychiatry Tokyo, Japan Less <<
NCT01009918 Breast Cancer ... More >> Cardiac Toxicity Less << Phase 2 Active, not recruiting November 2018 -
NCT01982695 - Completed - -
NCT00459056 Abdominal Obesity ... More >> Hypertension Less << Phase 3 Completed - United States, Minnesota ... More >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 Less <<
NCT01258764 Hypertension, Grade 1 ... More >> Hypertension Treatment N of 1 Study Design Hypertension Less << Not Applicable Completed - United States, California ... More >> Scripps Clinic La Jolla, California, United States, 92037 Less <<
NCT01982695 Duchenne Muscular Dystrophy (D... More >>MD) Cardiomyopathy Less << Not Applicable Completed - United States, California ... More >> University of California Davis Davis, California, United States United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States United States, Minnesota University of Minnesota St. Paul, Minnesota, United States United States, Missouri St. Louis Children's Hospital St. Louise, Missouri, United States United States, Ohio Nationwide Children's Hospital Columbus, Ohio, United States Less <<
NCT00624065 Hypertension Phase 3 Completed - -
NCT00459056 - Completed - -
NCT01984164 Hypertension ... More >>Mild Cognitive Impairment Less << Phase 3 Active, not recruiting December 15, 2018 United States, Georgia ... More >> Emory Univeristy Atlanta, Georgia, United States, 30329 Less <<
NCT00624065 - Completed - -
NCT01827878 Fed Phase 1 Completed - India ... More >> Accutest Research Lab (I) Pvt. Ltd. Ahmedabad, Gujarat, India, 380059 Less <<
NCT01380431 To Determine Bioequivalence Un... More >>der Fed Conditions Less << Phase 1 Completed - United States, Maryland ... More >> PharmaKinetics Laboratories, Inc. Baltimore, Maryland, United States, 21201 Less <<
NCT02232308 Gastroparesis Phase 1 Completed - United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01831700 Fasting Phase 1 Completed - India ... More >> Accutest Research Lab (I) Pvt. Ltd. Ahmedabad, Gujarat, India, 380059 Less <<
NCT01735318 Fasting Phase 1 Completed - India ... More >> Accutest Research Lab (I) Pvt. Ltd. Navi-Mumbai, Maharashtra, India Less <<
NCT01076140 Hypertension Not Applicable Withdrawn(No participants enro... More >>lled) Less << August 2011 United States, Mississippi ... More >> University of Mississippi Medical Center Jackson, Mississippi, United States, 39216 Less <<
NCT01735344 Fed Phase 1 Completed - India ... More >> Accutest Research Lab (I) Pvt. Ltd. Navi-Mumbai, Gujarat, India Less <<
NCT01066572 Stroke Phase 1 Completed - United Kingdom ... More >> Wansbeck General Hospital Ashington, Northumberland, United Kingdom, NE63 9JJ Royal Victoria Infirmary, Queen Victoria Road Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP North East Ambulance Service NHS Trust Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE15 8NY North Tyneside General Hospital North Shields, Tyne and Wear, United Kingdom, NE29 8NH Less <<
NCT01375244 Healthy Phase 1 Completed - United States, Maryland ... More >> PharmaKinetics Laboratories, Inc. Baltimore, Maryland, United States, 21201 Less <<
NCT03392740 Cardiomyopathy Due to Drug ... More >> Heart Failure, Systolic Less << Phase 4 Not yet recruiting March 15, 2020 United States, Michigan ... More >> Genesys Regional Medical Center Not yet recruiting Grand Blanc, Michigan, United States, 48439 Contact: Andrew A Hinojos    602-399-1174    andrew.hinojos@ascension.org    Contact: Thomas Miller       thomas.miller@ascension.org Less <<
NCT01491919 Hypertension Phase 1 Completed - United States, Alabama ... More >> University of Alabama Birmingham, Alabama, United States, 35233 United States, Arkansas Arkansas Children's Hospital Little Rock, Arkansas, United States, 72202 United States, Georgia Emory University and Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospitals & Clinics Kansas City, Missouri, United States, 64108 United States, New York New York University Langone Medical Center New York, New York, United States, 10016 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Less <<
NCT00347360 Hypertension Phase 3 Completed - -
NCT00347360 - Completed - -
NCT01491919 - Completed - -
NCT02184858 Primary Hypertension ... More >> Secondary Hypertension Less << Phase 4 Completed - Belgium ... More >> Department of Pediatrics and Medical Genetics Ghent, Belgium, 9000 Less <<
NCT01409837 Oligospermia Phase 2 Completed - Nigeria ... More >> University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria, 01129 Less <<
NCT01835418 Hypertension Not Applicable Unknown - -
NCT01880528 Dyspnea Non-s... More >>mall Cell Lung Cancer Small Cell Lung Cancer Less << Not Applicable Active, not recruiting November 1, 2018 United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Nebraska University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less <<
NCT01936012 Healthy Not Applicable Completed - Indonesia ... More >> PT Equilab International Jakarta, Indonesia, 12430 Less <<
NCT03599466 Healthy Phase 1 Not yet recruiting April 2019 -
NCT01409837 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.33mL

2.47mL

1.23mL

24.66mL

4.93mL

2.47mL

References

[1]Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.

[2]Gomez HJ, Cirillo VJ, Moncloa F. The clinical pharmacology of lisinopril. J Cardiovasc Pharmacol. 1987;9 Suppl 3:S27-34.

[3]Song JC. Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. doi: 10.2165/00003088-200241030-00005.

[4]Swaan PW. Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril. Biochim Biophys Acta. 1995 May 24;1236(1):31-8. doi: 10.1016/0005-2736(95)00030-7.

[5]Nemoto S. Differential effects of the angiotensin-converting enzyme inhibitor lisinopril versus the beta-adrenergic receptor blocker atenolol on hemodynamics and left ventricular contractile function in experimental mitral regurgitation. J Am Coll Cardiol. 2002 Jul 3;40(1):149-54. doi: 10.1016/s0735-1097(02)01926-5.

[6]Mantle D. Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension. Clin Chim Acta. 2000 Sep;299(1-2):1-10. doi: 10.1016/s0009-8981(00)00270-9.

[7]Mohammadi-Karakani A, Ghazi-Khansari M, Sotoudeh M. Lisinopril ameliorates paraquat-induced lung fibrosis. Clin Chim Acta. 2006 May;367(1-2):170-4. doi: 10.1016/j.cca.2005.12.012. Epub 2006 Feb 3.

[8]Selim Isbir C. The protective effect of lisinopril on membrane-bound enzymes in myocardial preservation. Cell Biochem Funct. 2000 Jun;18(2):85-91.

 

Historical Records

Categories