[ CAS No. 7757-21-3 ]

Name: (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride
Brand: Ambeed
SKU: A174443
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Quality Control of [ 7757-21-3 ]

COA GC NMR CNMR HPLC/UPLC LC-MS

Related Doc. of [ 7757-21-3 ]

SDS

Product Details of [ 7757-21-3 ]

CAS No. :	7757-21-3	MDL No. :	MFCD00050617
Formula :	C₈H₁₀ClN₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	183.64	Pubchem ID :	22000837
Synonyms :

Computed Properties of [ 7757-21-3 ]

TPSA :Topological Polar Surface Area	54.7	H-Bond Acceptor Count :	2
XLogP3 :	-	H-Bond Donor Count :	3
SP3 :	0.13	Rotatable Bond Count :	1

Safety of [ 7757-21-3 ]

Signal Word:	Warning	Class	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 7757-21-3 ]

Upstream synthesis route of [ 7757-21-3 ]
Downstream synthetic route of [ 7757-21-3 ]

[ 7757-21-3 ] Synthesis Path-Upstream 1~1

1
[ 95-54-5 ]
[ 56-40-6 ]
[ 7757-21-3 ]

Reference： [1] Journal of the American Chemical Society, 1984, vol. 106, # 6, p. 1801 - 1808
[2] Journal of the Chemical Society, Dalton Transactions, 2001, # 6, p. 828 - 837

[ 7757-21-3 ] Synthesis Path-Downstream 1~10

1
[ 106-93-4 ]
[ 7757-21-3 ]
[ 4744-53-0 ]

Yield	Reaction Conditions	Operation in experiment
50.4%		In a 100 mL three-necked flask, NaOH (15 g, 0.38 mol) and 15 mL of water were added, mechanically stirred, and after clearing, III-1 (2.63 g, 14.32 mmol) was added.Tetrabutylammonium bromide (185 mg, 0.57 mmol) was stirred at 25 C for 1 hour, and a solution of 1,2-dibromoethane (5.38 g, 28.64 mmol) dissolved in 50 mL of DMF was added dropwise.After the completion of the dropwise addition, the reaction was carried out at 25 C for 4 hours, and filtered by suction.Inorganic salt, concentrated under reduced pressure to give a white solid.Column chromatography (dichloromethane:methanol:aqueous ammonia = 50:1: 0.05 to 40:1:0.05) was purified to afford product (IV-1) 1.25 g, yield 50.4%.
50.4%		In a 100 mL three-necked flask, NaOH (15 g, 0.38 mol) and 15 mL of water were added, mechanically stirred, and after clearing, III-1 (2.63 g, 14.32 mmol), tetrabutylammonium bromide (185 mg, 0.57 mmol), The reaction was stirred at 25 C for 1 hour.A solution of 1,2-dibromoethane (5.38 g, 28.64 mmol) dissolved in 50 mL of DMF was added dropwise.After the dropwise addition, the reaction was carried out at 25 C for 4 hours, and the inorganic salt was removed by suction filtration, and concentrated under reduced pressure to give a white solid.Column chromatography (dichloromethane: methanol: ammonia = 50:1: 0.05 to 40:1:0.05),Compound IV-1The mass was 1.25 g and the yield was 50.4%.

Reference： [1]Patent: CN109251204,2019,A.Location in patent: Paragraph 0047; 0050; 0051
[2]Patent: CN109748923,2019,A.Location in patent: Paragraph 0057; 0061-0062

2
[ 128071-98-7 ]
[ 7757-21-3 ]
N-((1H-benzo[d]imidazol-2-yl)methyl)-4-(2-chloro-4-methoxyphenoxy)pyridin-2-amine [ No CAS ]

Reference： [1]Patent: WO2016/29146,2016,A1

3
[ 128071-98-7 ]
[ 7757-21-3 ]
N-((1H-benzo[d]imidazol-2-yl)methyl)-4-bromopyridin-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate; In N,N-dimethyl-formamide; at 90℃; for 0.166667h;Microwave irradiation;	A solution of 4-bromo-2-iluoropyridine (17.6 mg, 0.1 mmol), (IH- benzo[d]imidazol-2~yl)methanamine HCl salt (2.6.4 mg, 0.12 mmol), cesium carbonate (0.25 mmol) in DMF (1.0 mL) was microwave irradiated at 90 C for lOmin. The solvent wras then removed under vacuum. The residue was dissolved in EtOAc (25 mL), filtered. The organic layer was washed with brine (25 mL), dried and concentrated under vacuum. Purification by chromatography afforded the N-((l H-benzo[d]imidazol-2-yl)methyl)-4-bromopyridin-2- amine.

Reference： [1]Patent: WO2016/29146,2016,A1.Location in patent: Paragraph 0388

4
C₁₂H₉Cl₂NO₃ [ No CAS ]
[ 7757-21-3 ]
3-[(1H-benzoimidazol-2-ylmethyl)amino]-4-(2,4-dichlorobenzylamino)cyclobut-3-ene-1,2-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; In methanol; water; at 20℃;	2,4-Dichloro-benzylamine (47.3mg 0.269mmol) and 3,4-diraethoxy-3- cyiclobutene-l,2-dione (38.2mg, 0.269mmol) were combined in MeOH (2 ml) and water 104 (2ml) and stirred for 2h. C-(lH-benzoimidazol-2-yl)-methylamine HCI (59.4 mg, 0.269mmol) and sat. aHC( (lml) was added in situ. The mixture was stirred at room temperature overnight. After the mixture was extracted with ethyl acetate, washed with brine, concentrated under vacuum and purified via flash column chromatography to yield 3- [(lH-Benzoiniidazol-2-ylmemyl)-amino]-4-(2,4-dicUoro-benzylam dione(1769). LC/MS: (ESI) (M l i s 402.5.

Reference： [1]Patent: WO2016/29146,2016,A1.Location in patent: Paragraph 0149

5
[ 103-82-2 ]
[ 7757-21-3 ]
[ 121766-69-6 ]

Reference： [1]Organic and Biomolecular Chemistry,2015,vol. 13,p. 10888 - 10894

6
[ 95-54-5 ]
[ 56-40-6 ]
[ 7757-21-3 ]

Yield	Reaction Conditions	Operation in experiment
95.1%		O-phenylenediamine (II-1) (2.0 g, 18.49 mmol) was added to a 100 mL reaction flask, and 20 mL of 5.5 mol/L hydrochloric acid was added thereto, stirred and dissolved, and refluxed at 100 C for 1 hour, and glycine (2.77 g, 36.90 mmol) was added. The reaction was heated to reflux for 48 hours.TLC monitoring (dichloromethane: methanol = 10:1), the starting material was completely reacted, cooled to room temperature, a large amount of light green solid was precipitated, and suction filtered.Wash the filter cake with a small amount of ice ethanol and dry it.White solid (III-1) 3.23 g, yield 95.1%.
95.1%		Compound II-1 o-phenylenediamine (2.0 g, 18.49 mmol) was added to a 100 mL reaction flask, and 20 mL of 5.5 mol/L hydrochloric acid was added thereto, stirred and dissolved, and refluxed at 100 C for 1 hour, and glycine (2.77 g, 36.90 mmol) was added. The reaction was heated to reflux for 48 hours.TLC monitoring (dichloromethane: methanol = 10:1) The starting material was completely reacted, cooled to room temperature, a large amount of light green solid was precipitated, filtered, and the filter cake was washed with a small amount of iced ethanol.The white solid (III-1) was dried to 3.23 g, yield 95.1%.

Reference： [1]Patent: CN109251204,2019,A.Location in patent: Paragraph 0047; 0048; 0049
[2]Patent: CN109748923,2019,A.Location in patent: Paragraph 0057-0060
[3]Journal of the American Chemical Society,1984,vol. 106,p. 1801 - 1808
[4]Journal of the Chemical Society, Dalton Transactions,2001,p. 828 - 837

7
[ 7757-21-3 ]
[ 122-59-8 ]
[ 448225-31-8 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 371 - 378

8
[ 930598-37-1 ]
[ 7757-21-3 ]
[ 1351952-57-2 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 371 - 378

9
[ 1121-60-4 ]
[ 1830-54-2 ]
[ 7757-21-3 ]
dimethyl 1-((1H-benzimidazol-2-yl)methyl)-4-hydroxy-2,6-di(pyridin-2-yl)-1,2,3,6-tetrahydropyridine-3,5-dicarboxylate [ No CAS ]

Reference： [1]Zeitschrift fur Naturforschung, B: Chemical Sciences,2011,vol. 66,p. 721 - 728

10
[ 7757-21-3 ]
nickel dichloride [ No CAS ]
[Ni(2-aminomethylbenzimidazole)]⁽²⁺⁾ [ No CAS ]

Reference： [1]Journal of the Chemical Society, Dalton Transactions,1994,p. 3727 - 3732

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Code	Phrase
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P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
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P285	In case of inadequate ventilation wear respiratory protection.
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P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
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P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
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P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
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P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
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P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 7757-21-3 ]

Quality Control of [ 7757-21-3 ]

Related Doc. of [ 7757-21-3 ]

Product Details of [ 7757-21-3 ]

Computed Properties of [ 7757-21-3 ]

Safety of [ 7757-21-3 ]

Application In Synthesis of [ 7757-21-3 ]

[ 7757-21-3 ] Synthesis Path-Upstream 1~1

[ 7757-21-3 ] Synthesis Path-Downstream 1~10

Related Functional Groups of [ 7757-21-3 ]

Amines

Related Parent Nucleus of [ 7757-21-3 ]

Benzimidazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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Related Functional Groups of
[ 7757-21-3 ]

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[ 7757-21-3 ]