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Chemical Structure| 779353-01-4 Chemical Structure| 779353-01-4

Structure of Dinaciclib
CAS No.: 779353-01-4

Chemical Structure| 779353-01-4

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Dinaciclib is a potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.

Synonyms: SCH 727965; PS-095760

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Product Details of Dinaciclib

CAS No. :779353-01-4
Formula : C21H28N6O2
M.W : 396.49
SMILES Code : OCC[C@H]1N(CCCC1)C2=NC3=C(C=NN3C(NCC4=C[N+]([O-])=CC=C4)=C2)CC
Synonyms :
SCH 727965; PS-095760
MDL No. :MFCD16037702

Safety of Dinaciclib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Dinaciclib

Hedgehog

Isoform Comparison

Biological Activity

Target
  • CDK5

    CDK5, IC50:1 nM

  • CDK2

    CDK2, IC50:1 nM

  • CDK9

    CDK9, IC50:4 nM

  • CDK1

    CDK1, IC50:3 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
MCF7-Re cells 0.5 μM 48 h Dinaciclib significantly reduced BRCA1 phosphorylation and expression, induced more DNA damage and apoptosis, and significantly increased the sensitivity to cisplatin in MCF7-Re cells. PMC5913295
BCSphCs 10 nM 6 days To evaluate the effect of Dinaciclib on the cell viability of BCSphCs, results showed that Dinaciclib significantly reduced the cell viability of BCSphCs PMC8993694
CLB-GA cells 10 nM 8 h To investigate the effect of Dinaciclib on TERT mRNA expression and chromatin occupancy of epigenetic modulators at the TERT gene locus, results showed that Dinaciclib significantly inhibited TERT expression and reduced the binding of Brd4 and H3K27Ac at the TERT promoter or gene body. PMC7056551
Kelly cells 10 nM 8 h To investigate the effect of Dinaciclib on TERT mRNA expression, results showed that Dinaciclib significantly inhibited TERT expression. PMC7056551
HB PDX cells 0.1 µM 24 h Dinaciclib significantly inhibited the proliferation of PDX282 and PDX303 cells and induced apoptosis, while having less effect on PDX214 cells with low CDK9 expression. PMC11185924
THP-1 cells 10 nM 21 days Screening for CDK9 inhibitor-resistant cells PMC8567840
HCC PDXOs 1 μM 48 h To evaluate the cytotoxic effects of Dinaciclib on HCC PDXOs, results showed that Dinaciclib significantly reduced cell viability. PMC9377092
THLE-2 1 μM 48 h To evaluate the toxicity of Dinaciclib on non-tumorigenic liver epithelial cells THLE-2, results showed that Dinaciclib had lower toxicity on THLE-2 cells. PMC9377092

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice BCSphCs xenograft model Intraperitoneal injection 25 mg/kg 3 times per week for 3 weeks To evaluate the effect of Dinaciclib on tumor growth in the BCSphCs xenograft model, results showed that Dinaciclib significantly reduced tumor volume PMC8993694
nude mice CLB-GA xenograft model intraperitoneal injection 40 mg/kg daily, continuous treatment To investigate the effect of Dinaciclib on the growth of CLB-GA xenograft tumors, results showed that Dinaciclib significantly inhibited tumor growth, and the effect was enhanced when combined with AZD5153. PMC7056551
mice KrasG12DSetd2–/– lung tumor model intraperitoneal injection 20 mg/kg 3 times weekly for 7 weeks dinaciclib markedly suppressed the growth of KrasG12DSetd2–/– lung tumors and significantly prolonged the survival of mice PMC9977508
Nude mice HB PDX model Intraperitoneal injection 20 mg/kg 3 times per week for 11 days Dinaciclib significantly reduced the volume of PDX282 tumors but also caused some side effects such as weight loss and unexpected death. PMC11185924
Mice HCC PDX model Intraperitoneal injection 5 mg/kg Three times a week until tumors reached endpoint volume To evaluate the tumor suppressive effects of Dinaciclib in combination with Ixazomib on HCC PDX tumors, results showed that the combination treatment significantly inhibited tumor growth and outperformed Sorafenib alone. PMC9377092

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00937937 Acral Lentiginous Melanoma|Cut... More >>aneous Nodular Melanoma|Lentigo Maligna Melanoma|Low-CSD Melanoma|Mucosal Melanoma|Recurrent Melanoma|Stage IV Cutaneous Melanoma AJCC v6 and v7 Less << PHASE2 ACTIVE_NOT_RECRUITING 2025-03-08 Providence Hospital, Mobile, A... More >>labama, 36608, United States|Mercy Hospital Fort Smith, Fort Smith, Arkansas, 72903, United States|University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, United States|Highlands Oncology Group - Rogers, Rogers, Arkansas, 72758, United States|East Bay Radiation Oncology Center, Castro Valley, California, 94546, United States|Eden Hospital Medical Center, Castro Valley, California, 94546, United States|Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California, 94546, United States|Bay Area Breast Surgeons Inc, Emeryville, California, 94608, United States|Valley Medical Oncology Consultants-Fremont, Fremont, California, 94538, United States|Contra Costa Regional Medical Center, Martinez, California, 94553-3156, United States|El Camino Hospital, Mountain View, California, 94040, United States|Highland General Hospital, Oakland, California, 94602, United States|Alta Bates Summit Medical Center - Summit Campus, Oakland, California, 94609, United States|Bay Area Tumor Institute, Oakland, California, 94609, United States|Hematology and Oncology Associates-Oakland, Oakland, California, 94609, United States|Tom K Lee Inc, Oakland, California, 94609, United States|UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, 92868, United States|Valley Care Health System - Pleasanton, Pleasanton, California, 94588, United States|Valley Medical Oncology Consultants, Pleasanton, California, 94588, United States|Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California, 94806, United States|Poudre Valley Hospital, Fort Collins, Colorado, 80524, United States|Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, 06105, United States|Boca Raton Comprehensive Cancer Center, Boca Raton, Florida, 33486, United States|Orlando Health Cancer Institute, Orlando, Florida, 32806, United States|Memorial Health University Medical Center, Savannah, Georgia, 31404, United States|Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, 31405, United States|South Georgia Medical Center/Pearlman Cancer Center, Valdosta, Georgia, 31602, United States|OSF Saint Anthony's Health Center, Alton, Illinois, 62002, United States|Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, 62526, United States|Decatur Memorial Hospital, Decatur, Illinois, 62526, United States|Advocate Good Samaritan Hospital, Downers Grove, Illinois, 60515, United States|Loyola University Medical Center, Maywood, Illinois, 60153, United States|SSM Health Good Samaritan, Mount Vernon, Illinois, 62864, United States|Springfield Memorial Hospital, Springfield, Illinois, 62781, United States|Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana, 46107, United States|Reid Health, Richmond, Indiana, 47374, United States|Cancer Center of Kansas - Chanute, Chanute, Kansas, 66720, United States|Cancer Center of Kansas - Dodge City, Dodge City, Kansas, 67801, United States|Cancer Center of Kansas - El Dorado, El Dorado, Kansas, 67042, United States|Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, 66701, United States|HaysMed, Hays, Kansas, 67601, United States|Hutchinson Regional Medical Center, Hutchinson, Kansas, 67502, United States|Cancer Center of Kansas-Independence, Independence, Kansas, 67301, United States|University of Kansas Cancer Center, Kansas City, Kansas, 66160, United States|Cancer Center of Kansas-Kingman, Kingman, Kansas, 67068, United States|Lawrence Memorial Hospital, Lawrence, Kansas, 66044, United States|Southwest Medical Center, Liberal, Kansas, 67901, United States|Cancer Center of Kansas-Liberal, Liberal, Kansas, 67905, United States|Cancer Center of Kansas - Newton, Newton, Kansas, 67114, United States|Olathe Cancer Center, Olathe, Kansas, 66061, United States|Menorah Medical Center, Overland Park, Kansas, 66209, United States|Saint Luke's South Hospital, Overland Park, Kansas, 66213, United States|Cancer Center of Kansas - Parsons, Parsons, Kansas, 67357, United States|Ascension Via Christi - Pittsburg, Pittsburg, Kansas, 66762, United States|Kansas City NCI Community Oncology Research Program, Prairie Village, Kansas, 66208, United States|Cancer Center of Kansas - Pratt, Pratt, Kansas, 67124, United States|Cancer Center of Kansas - Salina, Salina, Kansas, 67401, United States|Salina Regional Health Center, Salina, Kansas, 67401, United States|Advent Health - Shawnee Mission Medical Center, Shawnee Mission, Kansas, 66204, United States|Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas, 66606, United States|University of Kansas Health System Saint Francis Campus, Topeka, Kansas, 66606, United States|Cancer Center of Kansas - Wellington, Wellington, Kansas, 67152, United States|Associates In Womens Health, Wichita, Kansas, 67208, United States|Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, 67208, United States|Ascension Via Christi Hospitals Wichita, Wichita, Kansas, 67214, United States|Cancer Center of Kansas - Wichita, Wichita, Kansas, 67214, United States|Wichita NCI Community Oncology Research Program, Wichita, Kansas, 67214, United States|Cancer Center of Kansas - Winfield, Winfield, Kansas, 67156, United States|Baton Rouge General Medical Center, Baton Rouge, Louisiana, 70806, United States|Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, 70809, United States|Louisiana State University Health Science Center, New Orleans, Louisiana, 70112, United States|University Medical Center New Orleans, New Orleans, Louisiana, 70112, United States|Boston Medical Center, Boston, Massachusetts, 02118, United States|Michigan Cancer Research Consortium NCORP, Ann Arbor, Michigan, 48106, United States|Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, 48106, United States|University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, United States|Bronson Battle Creek, Battle Creek, Michigan, 49017, United States|Spectrum Health Big Rapids Hospital, Big Rapids, Michigan, 49307, United States|Corewell Health Dearborn Hospital, Dearborn, Michigan, 48124, United States|Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|Henry Ford Health Saint John Hospital, Detroit, Michigan, 48236, United States|Hurley Medical Center, Flint, Michigan, 48503, United States|Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, 48532, United States|Cancer Research Consortium of West Michigan NCORP, Grand Rapids, Michigan, 49503, United States|Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, 49503, United States|Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, 49503, United States|Allegiance Health, Jackson, Michigan, 49201, United States|University of Michigan Health - Sparrow Lansing, Lansing, Michigan, 48912, United States|Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, 48154, United States|Trinity Health Muskegon Hospital, Muskegon, Michigan, 49444, United States|Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan, 48341, United States|Lake Huron Medical Center, Port Huron, Michigan, 48060, United States|MyMichigan Medical Center Saginaw, Saginaw, Michigan, 48601, United States|Munson Medical Center, Traverse City, Michigan, 49684, United States|Henry Ford Health Warren Hospital, Warren, Michigan, 48093, United States|University of Michigan Health - West, Wyoming, Michigan, 49519, United States|Saint Francis Medical Center, Cape Girardeau, Missouri, 63703, United States|University Health Truman Medical Center, Kansas City, Missouri, 64108, United States|Saint Luke's Hospital of Kansas City, Kansas City, Missouri, 64111, United States|Saint Joseph Health Center, Kansas City, Missouri, 64114, United States|North Kansas City Hospital, Kansas City, Missouri, 64116, United States|Heartland Hematology and Oncology Associates Incorporated, Kansas City, Missouri, 64118, United States|Research Medical Center, Kansas City, Missouri, 64132, United States|Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, 64086, United States|Liberty Radiation Oncology Center, Liberty, Missouri, 64068, United States|Heartland Regional Medical Center, Saint Joseph, Missouri, 64506, United States|Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, 63109, United States|Mercy Hospital Saint Louis, Saint Louis, Missouri, 63141, United States|Saint Louis-Cape Girardeau CCOP, Saint Louis, Missouri, 63141, United States|Billings Clinic Cancer Center, Billings, Montana, 59101, United States|Northern Rockies Radiation Oncology Center, Billings, Montana, 59101, United States|Saint Vincent Healthcare, Billings, Montana, 59101, United States|Montana Cancer Consortium NCORP, Billings, Montana, 59102, United States|Saint Vincent Frontier Cancer Center, Billings, Montana, 59102, United States|Bozeman Health Deaconess Hospital, Bozeman, Montana, 59715, United States|Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, 59701, United States|Benefis Sletten Cancer Institute, Great Falls, Montana, 59405, United States|Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, 59405, United States|Great Falls Clinic, Great Falls, Montana, 59405, United States|Northern Montana Hospital, Havre, Montana, 59501, United States|Saint Peter's Community Hospital, Helena, Montana, 59601, United States|Glacier Oncology PLLC, Kalispell, Montana, 59901, United States|Kalispell Medical Oncology, Kalispell, Montana, 59901, United States|Logan Health Medical Center, Kalispell, Montana, 59901, United States|Montana Cancer Specialists, Missoula, Montana, 59802, United States|Saint Patrick Hospital - Community Hospital, Missoula, Montana, 59802, United States|Community Medical Center, Missoula, Montana, 59804, United States|Guardian Oncology and Center for Wellness, Missoula, Montana, 59804, United States|University Medical Center of Southern Nevada, Las Vegas, Nevada, 89102, United States|Nevada Cancer Institute-Summerlin Campus, Las Vegas, Nevada, 89135, United States|University of Rochester, Rochester, New York, 14642, United States|Novant Health Presbyterian Medical Center, Charlotte, North Carolina, 28204, United States|Wayne Memorial Hospital, Goldsboro, North Carolina, 27534, United States|FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, 28374, United States|Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem, North Carolina, 27104, United States|Grandview Hospital, Dayton, Ohio, 45405, United States|Good Samaritan Hospital - Dayton, Dayton, Ohio, 45406, United States|Miami Valley Hospital, Dayton, Ohio, 45409, United States|Miami Valley Hospital North, Dayton, Ohio, 45415, United States|Dayton NCI Community Oncology Research Program, Dayton, Ohio, 45459, United States|Blanchard Valley Hospital, Findlay, Ohio, 45840, United States|Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, 45005-1066, United States|Wayne Hospital, Greenville, Ohio, 45331, United States|Kettering Medical Center, Kettering, Ohio, 45429, United States|Upper Valley Medical Center, Troy, Ohio, 45373, United States|Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington, Ohio, 45177, United States|Greene Memorial Hospital, Xenia, Ohio, 45385, United States|Saint Charles Health System, Bend, Oregon, 97701, United States|Providence Milwaukie Hospital, Milwaukie, Oregon, 97222, United States|Providence Portland Medical Center, Portland, Oregon, 97213, United States|Adventist Medical Center, Portland, Oregon, 97216, United States|Providence Saint Vincent Medical Center, Portland, Oregon, 97225, United States|Salem Hospital, Salem, Oregon, 97301, United States|Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina, 29316, United States|Prisma Health Cancer Institute - Easley, Easley, South Carolina, 29640, United States|McLeod Regional Medical Center, Florence, South Carolina, 29506, United States|Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, 29601, United States|Saint Francis Hospital, Greenville, South Carolina, 29601, United States|Prisma Health Cancer Institute - Butternut, Greenville, South Carolina, 29605, United States|Prisma Health Cancer Institute - Faris, Greenville, South Carolina, 29605, United States|Prisma Health Greenville Memorial Hospital, Greenville, South Carolina, 29605, United States|Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, 29615, United States|Self Regional Healthcare, Greenwood, South Carolina, 29646, United States|Prisma Health Cancer Institute - Greer, Greer, South Carolina, 29650, United States|Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, 29672, United States|Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee, 37660, United States|Thompson Cancer Survival Center, Knoxville, Tennessee, 37916, United States|Medical City Dallas Hospital, Dallas, Texas, 75230, United States|Scott and White Memorial Hospital, Temple, Texas, 76508, United States|Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, 84112, United States|Danville Regional Medical Center, Danville, Virginia, 24541, United States|Sovah Health Martinsville, Martinsville, Virginia, 24112, United States|Ballad Health Cancer Care - Norton, Norton, Virginia, 24273, United States|PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, 98225, United States|Kadlec Clinic Hematology and Oncology, Kennewick, Washington, 99336, United States|Skagit Valley Hospital, Mount Vernon, Washington, 98274, United States|Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, 98370, United States|Harborview Medical Center, Seattle, Washington, 98104, United States|Minor and James Medical PLLC, Seattle, Washington, 98104, United States|Fred Hutchinson Cancer Center, Seattle, Washington, 98109, United States|Kaiser Permanente Washington, Seattle, Washington, 98112, United States|Swedish Medical Center-First Hill, Seattle, Washington, 98122, United States|University of Washington Medical Center - Montlake, Seattle, Washington, 98195, United States|Saint Michael Cancer Center, Silverdale, Washington, 98383, United States|Cancer Care Northwest - Spokane South, Spokane, Washington, 99202, United States|Evergreen Hematology and Oncology PS, Spokane, Washington, 99218, United States|PeaceHealth Southwest Medical Center, Vancouver, Washington, 98664, United States|Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, 98801, United States|Rocky Mountain Oncology, Casper, Wyoming, 82609, United States|Welch Cancer Center, Sheridan, Wyoming, 82801, United States Less <<
NCT00871663 Solid Tumors|Lymphoma, Non-Hod... More >>gkin|Multiple Myeloma|Leukemia, Lymphocytic, Chronic. B-Cell Less << PHASE1 COMPLETED 2025-10-12 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL

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