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[ CAS No. 790667-68-4 ] {[proInfo.proName]}

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Chemical Structure| 790667-68-4
Chemical Structure| 790667-68-4
Structure of 790667-68-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 790667-68-4 ]

CAS No. :790667-68-4 MDL No. :MFCD11849730
Formula : C16H24N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :292.37 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 790667-68-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 790667-68-4 ]

[ 790667-68-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21900-54-9 ]
  • [ 790667-68-4 ]
  • [ 790668-62-1 ]
YieldReaction ConditionsOperation in experiment
98% With pyridine In dichloromethane at 0 - 20℃; for 1.5h; 77 Add pyridine (0.66 mL, 8.21 mmol) to a solution of 4- (3-amino-phenoxy)- PIPERIDINE-1-CARBOXYLIC acid TERT-BUTYL ester (preparation 30,2. 0 g, 6.84 mmol) in dichloromethane (35 mL) at 0°C. Stir and add 2-chloro-4-fluorobenzoyl chloride dropwise (1.45 g, 7. 52 mmol). Stir at 0°C for 30 min and 1 HR. at room temperature. Dilute with dichloromethane (30 mL) and wash with sodium hydroxide (IN, 2x25 mL). Combine the organic layers, dry over sodium sulfate and concentrate under reduced pressure. Purification by flash chromatography, eluting with ethyl acetate/hexanes [20- 40%] to give the title compound (3.0 g, 98%). Mass spectrum (ion spray): m/z = 449.0 (M+1) ; H NMR (CDC13) : 7.87 (bs, N-H), 7.80 (dd, J = 6.1 Hz, 8.6 Hz, 1H), 7.48 (s, 1H), 7. 28-7. 24 (m, 1H), 7.21 (dd, J = 2. 5 HZ, 8. 4 Hz, 1H), 7.11 (td, J= 2. 2 HZ, 8. 4 HZ, 1H), 7.03 (d, J= 8.4 Hz, 1H), 6.73 (dd, J= 2.2 Hz, 8.4 Hz, 1H), 4.52 (septet, J = 3.6 Hz, 1H), 3.69 (ddd, J= 3.7 Hz, 7. 7 Hz, 13. 6 Hz, 2H), 3. 3-5 (DDD,-J= 3. 9 Hz, 7.7 Hz, 1-3. 6 Hz, 2H), 1.97-1. 89 (m, 2H), 1.81-1. 72 (m, 2H), 1.46 (s, 9H).
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