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CAS No. : | 79421-44-6 | MDL No. : | MFCD05864666 |
Formula : | C12H15NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XORVVRSWELVXLH-UHFFFAOYSA-N |
M.W : | 205.25 | Pubchem ID : | 12717446 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 37 h; Inert atmosphere | 4-Hydroxypiperidine (6.24 g, 0.06 mol),4-Fluorobenzaldehyde (5 g, 0.04 mol)And K2CO3 (8.44 g, 0.06 mol)Was dissolved in dimethylformamide (150 mL)And stirred at 70 & lt; 0 & gt; C for 37 hours under a nitrogen atmosphere,K2CO3 was removed by suction filtration and the dimethylformamide was vaporized.Then, it was dried in a vacuum oven at 80 for 12 hours and then purified by a chromatographic method to obtain 4- (4-hydroxypiperidin-1-yl) benzaldehyde. [Yield = 61percent. |
52% | With sodium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 8 h; | Dimethylformamide (15 mL) was added to 4-fluorobenzaldehyde (1.5 g, 0.012 mol) and sodium carbonate (2.5 g, 0.018 mol). Piperidin-4-ol (1.47 g, 0.015 mol) was slowly added dropwise thereto, followed by stirring for 8 hours at 70 to 80°C. Dichloromethane was added to the reaction solution, and the mixture was washed with an aqueous solution of saturated sodium bicarbonate. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and distilled under reduced pressure. The resulting residue was crystallized with n-hexane to obtain the title compound (1 .5 g, yield: 52percent). 'H-NMR(300 MHZ, DMSO-d6) δ 1 .40 (m, 2H), 1.79 (m, 2H), 3.10 (m, 2H), 3.75 (m, 3H), 4.77 (d, 1H), 7.02 (d, 2H), 7.68 (d, 2H), 9.67 (s, 1 H) |
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