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[ CAS No. 81777-47-1 ] {[proInfo.proName]}

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Chemical Structure| 81777-47-1
Chemical Structure| 81777-47-1
Structure of 81777-47-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 81777-47-1 ]

CAS No. :81777-47-1 MDL No. :
Formula : C10H11ClN4O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 270.67 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 81777-47-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 81777-47-1 ]
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[ 81777-47-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 81777-47-1 ]
  • [ 31383-66-1 ]
YieldReaction ConditionsOperation in experiment
78% With ammonia In methanol at 150℃; for 24 h; A solution of compound 15 (0.65 g, 2.4 mmol) in saturated methanolic ammonia (15 mL) was sealed in a steel bomb which was then placed in an oil bath maintained at 150°C for 24 h. On cooling, the mixture was removed from the bomb, concentrated to dryness and purified by silica gel column chromatography (eluent: CH2Cl2/MeOH 90/10, v/v) to afford desiderated compound 16 as white solid (yield 78percent). 1H-NMR (200MHz, DMSO-d6) d: 3.46-3.53 (4H, m, 2 x CH2); 4.67 (1H, t, OH); 5.55 (2H, s, OCH2N); 7.28 (2H, br s, NH2); 8.17 (1H, s, H-2); 8.27 (1H, s, H-8). ESI MS: m/z 210.1 Da [M+H]+, C8H11N5O2 Mol. Wt. 209.21.
Reference: [1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 202 - 209
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