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[ CAS No. 82683-51-0 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 82683-51-0
Chemical Structure| 82683-51-0
Structure of 82683-51-0 *Storage: {[proInfo.prStorage]}

Quality Control of [ 82683-51-0 ]

Related Doc. of [ 82683-51-0 ]

SDS

Product Details of [ 82683-51-0 ]

CAS No. :82683-51-0MDL No. :MFCD03844397
Formula : C10H14O2 Boiling Point : 314°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :166.22Pubchem ID :4831594
Synonyms :

Computed Properties of [ 82683-51-0 ]

TPSA : 34.1 H-Bond Acceptor Count : 2
XLogP3 : 1.7 H-Bond Donor Count : 0
SP3 : 0.80 Rotatable Bond Count : 0

Safety of [ 82683-51-0 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 82683-51-0 ]

  • Upstream synthesis route of [ 82683-51-0 ]
  • Downstream synthetic route of [ 82683-51-0 ]

[ 82683-51-0 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 933-02-8 ]
  • [ 105-53-3 ]
  • [ 82683-51-0 ]
YieldReaction ConditionsOperation in experiment
56%
Stage #1: Reflux
Stage #2: for 24.00 h; Reflux
Stage #3: With hydrogenchloride In water
A mixture of 1 -cyclopentylidene-propan-2-one (1 g, 9.4 mmol) and diethyl malonate (1 .75 g, 1 1 mmol) is added dropwise to a slution of sodium methoxide prepared by dissolving sodium (0.25 g, 1 1 mmol) in MeOH (3 ml_). The mixture is heated to reflux for 2 h, then a hot solution of barium hydroxide (1 1 .23 g, 73 mmol) in 100 ml_ of water is added and the mixture is refluxed for 24 h, then neutralized to pH 6 with diluted hydrochloric acid while still hot and filtered. The filtrate is cooled and acidified to pH 1 with diluted hydrochloric acid, refluxed for 15 min, filtered while hot and then cooled. The formed precipitate is filtered, washed with water and dried to give 0.87 g (56percent) of spiro[4.5]decane-7,9-dione.
46%
Stage #1: With sodium In methanol at 20℃; for 2.00 h; Reflux
Stage #2: With barium(II) hydroxide In methanol; water for 24.00 h; Reflux
Step ii: spiro[4.51decane-7,9-dione
To a 250 mL round bottom flask, was added methanol (3 mL). To the same flask, sodium metal (0.25 g, 0.008 mol) was added portion wise. The reaction mixture was stirred at room temperature until all sodium metal had dissolved. To the same flask, 1 -cyclopentylidenepropan- 2-one (1 g, 0.008 mol) and diethyl malonate (1.75 g, 0.0096 mol) were added drop wise. The resulting mixture was stirred at reflux temperature for 2 h. To the reaction mixture, a solution of barium hydroxide (11.23 g, 0.064 mol) in water (100 mL) was added. The hot reaction mixture was stirred at reflux temperature for 24 h and acidified to pH 6.0 with dil. hydrochloric acid to get the suspension. The hot suspension was filtered to get a clear filtrate. The filtrate was acidified to pH 1.0 with dil. hydrochloric acid and stirred at reflux temperature for 15 min. The hot reaction mixture was filtered to get the filtrate. The filtrate was cooled to room temperature and extracted with ethyl acetate. The organic layer was separated, washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to get the title compound [0.65 g, 46 percent]. NMR (300 MHz, CDC13): δ 3.63 (s, 2H), 2.61 (s, 4H), 1.73 - 1.67 (m, 4H), 1.49-1.45 (m, 4H); LC-MS: 167.2 [M+H]+.
Reference: [1] Helvetica Chimica Acta, 2001, vol. 84, # 7, p. 2071 - 2088
[2] Patent: WO2012/52451, 2012, A1. Location in patent: Page/Page column 48
[3] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 115; 116
  • 2
  • [ 67570-15-4 ]
  • [ 82683-51-0 ]
Reference: [1] Helvetica Chimica Acta, 2001, vol. 84, # 7, p. 2071 - 2088
  • 3
  • [ 38134-31-5 ]
  • [ 82683-51-0 ]
Reference: [1] Helvetica Chimica Acta, 2001, vol. 84, # 7, p. 2071 - 2088
  • 4
  • [ 120-92-3 ]
  • [ 82683-51-0 ]
Reference: [1] Patent: WO2015/101928, 2015, A1
  • 5
  • [ 823-91-6 ]
  • [ 82683-51-0 ]
Reference: [1] Journal of the Chemical Society, 1921, vol. 119, p. 1206
  • 6
  • [ 141-52-6 ]
  • [ 82683-51-0 ]
Reference: [1] Journal of the Chemical Society, 1929, p. 719
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