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[ CAS No. 82961-52-2 ] {[proInfo.proName]}

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Chemical Structure| 82961-52-2
Chemical Structure| 82961-52-2
Structure of 82961-52-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 82961-52-2 ]

CAS No. :82961-52-2 MDL No. :MFCD08458263
Formula : C8H9ClS Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 172.68 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 82961-52-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82961-52-2 ]

[ 82961-52-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 87-60-5 ]
  • [ 5188-07-8 ]
  • [ 82961-52-2 ]
YieldReaction ConditionsOperation in experiment
75.1% In a 2L four-necked flask fitted with a reflux condensation device, 3-chloro-2-methylaniline was added 200g (1.42mol), water 380g (21mol), concentrated hydrochloric acid was added dropwise 425g (4mol), maintaining the reaction temperature did not exceed 15 deg.] C, was added dropwise with hydrochloric acid to precipitate a white solid, after the addition was complete stirring was continued for 20min, then cooled back down 5 , aqueous solution of sodium nitrite (containing NaNO2102g, H2O290g), maintaining the reaction temperature did not exceed 10 , with the aqueous solution of sodium nitrite as a white solid gradually dissolved, the reaction solution becomes reddish brown, stirring was continued for 0.5h, the reaction solution was set aside; In a 2L four-necked flask with a condensed reflux device,600 g (1.70 mol) of 20% sodium methanethiolate, 56 g (1.4 mol) of sodium hydroxide and 61 g (0.45 mol) of potassium carbonateMol), stirring until the solid is completely dissolved, dropping the above-mentioned solution to keep the reaction temperature not exceeding 10 , dropping finished, continue to reaction 24h. After completion of the reaction, the mixture was extracted with 300 mL of dichloroethane, and then dichloroethane was distilled off under reduced pressure to obtain 180 g of a yellow solution in a yield of 75.1% and a purity of 99.5%.
  • 2
  • [ 82961-52-2 ]
  • [ 106904-09-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 1,2-dichloro-ethane / 24 h / 20 °C 2: sodium tungstate; dihydrogen peroxide / acetic acid / 1 h / 80 °C 3: sodium hypochlorite / 1,4-dioxane / 80 °C
  • 3
  • [ 74-93-1 ]
  • [ 118-69-4 ]
  • [ 82961-52-2 ]
YieldReaction ConditionsOperation in experiment
93.4% General procedure: Powdered potassium hydroxide (19.5 g, 0.313 mol)Put 200ml of toluene for beating,And pass the methyl mercaptan gas,The temperature of the reaction system was controlled at 5 C and aeration for 0.5 hours.Then, triethylenediamine (1.7 g, 0.015 mol),<strong>[118-69-4]2,6-dichlorotoluene</strong> (50 g, 0.307 mol),The temperature was raised to 52 C for 5 hours, and the temperature was lowered to room temperature.Add 100ml of water for washing and stratification.After layering, the oil layer is obtained.The oil layer is first concentrated with a water ring vacuum pump to remove toluene.The residue is extracted with 2-chloro-6-methylthiotoluene using a high vacuum oil pump.49.4 g of a pale yellow oily liquid,The content of 2-chloro-6-methylthiotoluene was determined to be 99.1%.The yield was 92.3%.
  • 4
  • [ 118-69-4 ]
  • [ 5188-07-8 ]
  • [ 82961-52-2 ]
YieldReaction ConditionsOperation in experiment
With 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate; In water; at 100℃; under 600.06 Torr; for 3h; To 400ml of 1-butyl-2,3-dimethylimidazole hexafluorophosphate was added 650g 20%Aqueous solution of sodium methyl mercaptan, heated to a reduced pressure and distilled to 100C/0.08MPa, keeping no distillate flowing out, then suspending heating, adding 200g of <strong>[118-69-4]2,6-dichlorotoluene</strong> to the system, maintaining at 100C for 3 hours, then cooling to 35 , 30g of methyl chloride gas was introduced into the kettle, kept for 1 hour, and atmospheric distillation was started. After 55 and no distillate flowed out, it was changed to another receiving bottle and vacuum distillation was started. It stopped after 180/0.09MPa heating,A total of 205 g of distillate was received, which was 2-methylthio-6-chlorotoluene with a yield of 97.3%; after the vacuum distillation was completed, the remaining ionic liquid solution was filtered to remove inorganic salts for recovery
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