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[ CAS No. 83-12-5 ]

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Cat. No.: {[proInfo.prAm]}
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type HazMat fee
Excepted Quantity Free
Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
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2D
Chemical Structure| 83-12-5
Chemical Structure| 83-12-5
Structure of 83-12-5 *Storage: {[proInfo.prStorage]}

Quality Control of [ 83-12-5 ]

Related Doc. of [ 83-12-5 ]

SDS
Alternatived Products of [ 83-12-5 ]
Alternatived Products of [ 83-12-5 ]

Product Details of [ 83-12-5 ]

CAS No. :83-12-5MDL No. :MFCD00003782
Formula : C15H10O2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :222.24Pubchem ID :4760
Synonyms :

1. Phenindione

Computed Properties of [ 83-12-5 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 83-12-5 ]

Signal Word:DangerClass:6.1
Precautionary Statements:P280-P301+P310UN#:2811
Hazard Statements:H301-H317Packing Group:
GHS Pictogram:

Application In Synthesis of [ 83-12-5 ]

  • Downstream synthetic route of [ 83-12-5 ]

[ 83-12-5 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 87-41-2 ]
  • [ 100-52-7 ]
  • [ 83-12-5 ]
YieldReaction ConditionsOperation in experiment
88% With sodium methylate; In methanol; ethyl acetate; at 80℃; for 5h;Cooling; General procedure: In a 2-neck round bottom flask, phthalide (3.75 g, 0.028 mol) and 1-trityl-1H-imidazole-4-carboxaldehyde (9.47 g, 0.028 mol) were added to ethyl acetate (25 mL). A cooled solution of sodium methoxide (10%, 50 mL) was added dropwise to the reaction mixture, and the mixture was stirred for 5 h at 80 C. After vacuum removal the solvent, the residue was poured into water and acidified by 1N hydrochloric acid to pH 4.5.The precipitate was filtered and washed with water and recrystallized from ethanol to afford 9.75 g (76 %) of crystalline product 2, mp 212-214 C (lit. 213-215 C).
52% With sodium methylate; In methanol; for 2h;Reflux; A solution of sodium methoxide in methanol (28%, 2.196 g, 11.4 mmol) was added to a suspension of benzaldehyde (307 mg, 2.89 mmol) and phthalide (387 mg, 2.89 mmol) in ethyl propionate (1.2 mL) at 30 C, and the mixture was heated under reflux for 1 h. The reaction mixture was diluted with methanol and, was further heated for 1 h. After concentration in vacuo, water was added to the residue, and was washed with diethyl ether. After acidified with acetic acid, the suspension was stirred for 15 min. The product was collected by filtration, washed with water, and dried in vacuo to afford 12 (331 mg, 52%) as colorless powder. 1H NMR (400 M Hz, CDCl3) delta 8.08 (dd, J = 2.9 Hz, 2H), 7.91 (dd, J = 2.9 Hz, 2H), 7.35-7.26 (m, 3H), 7.19 (dd, J = 8.8, 2.0 Hz, 2H), 4.27 (s, 1H).
  • 5
  • [ 83-12-5 ]
  • [ 106-49-0 ]
  • 2-phenyl-3-(p-tolylamino)-1H-inden-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% at 100 - 110℃; for 1h; General procedure: A mixture of 2-phenyl-indan-1,3-dione PI (1a, 1b; 2.2 mg; 10 mmol), prepared according to literature, [27,28] and the corresponding primary aromatic amines 2 (10 mmol), namely, aniline, p-toluidine, p-anisidine, p-chloroaniline and p-nitroaniline, was fused at 100-110 C for 1 h and left stirring overnight. The condensation of PI with the different aromatic amines proceeded via a nucleophilic attack of the amines followed by elimination of one water molecule [29]. The solid compounds obtained were filtered and recrystallized from the appropriate solvent to give PHI, PMI, PMOI, PCI, and PNI, respectively (3a and 3b, in Scheme 1).
  • 6
  • [ 83-12-5 ]
  • [ 104-94-9 ]
  • 3-(p-anisidino)-2-phenyl-1H-inden-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% at 100 - 110℃; for 1h; General procedure: A mixture of 2-phenyl-indan-1,3-dione PI (1a, 1b; 2.2 mg; 10 mmol), prepared according to literature, [27,28] and the corresponding primary aromatic amines 2 (10 mmol), namely, aniline, p-toluidine, p-anisidine, p-chloroaniline and p-nitroaniline, was fused at 100-110 C for 1 h and left stirring overnight. The condensation of PI with the different aromatic amines proceeded via a nucleophilic attack of the amines followed by elimination of one water molecule [29]. The solid compounds obtained were filtered and recrystallized from the appropriate solvent to give PHI, PMI, PMOI, PCI, and PNI, respectively (3a and 3b, in Scheme 1).
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