[ CAS No. 830346-49-1 ] {[proInfo.proName]}

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Quality Control of [ 830346-49-1 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 830346-49-1 ]

CAS No. :	830346-49-1	MDL No. :
Formula :	C₂₆H₂₆BrF₄N₃O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	600.40	Pubchem ID :	-
Synonyms :

Safety of [ 830346-49-1 ]

Signal Word:	Class:	N/A
Precautionary Statements:	UN#:	N/A
Hazard Statements:	Packing Group:	N/A

Application In Synthesis of [ 830346-49-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 830346-49-1 ]

[ 830346-49-1 ] Synthesis Path-Downstream 1~7

1
[ 830346-48-0 ]
(R)-N-(tert-butoxycarbonyl)phenylglycinol [ No CAS ]
[ 830346-49-1 ]

Yield	Reaction Conditions	Operation in experiment
99%	With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 14h;	Add <strong>[830346-48-0]5-bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione</strong> (2.2g, 5.8mmol at 25) )withTetrahydrofuran (35mL) was added to a 100mL single-necked round bottom flask, and (R)-tert-butyl (2-hydroxy-1-phenylethyl) carbamate (1.7g, 7.2mmol) andTriphenylphosphine (2.3g, 8.7mmol), then add diethyl azodicarboxylate (2.0g, 8.5mmol), continue to stir and react for 14 hours;The reaction was stopped, the product was spin-dried under reduced pressure, and separated and purified by column chromatography (petroleum ether/ethyl acetate (v/v)=3/1) to obtain the title compound as a white solid (3.42 g, 99%).
70%	With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In toluene; at 5 - 20℃;	To a stirred solution of 5-bromo-l-[2-fluoro-6-(trifluoromethyl)benzyl]-6- methylpyrimidine-2,4(lH,3H)-dione of Formula V (25 g) in toluene (275 ml) were added N- t-Boc-D-phenylglycinol of Formula VI (R3=OH, PG=Boc) (19.5 g) and triphenylphosphine (25.6 g) followed by slow addition of di tert-butyl azodicarboxylate in toluene solution (22.5 g in 100 ml) at 5-10C and stirred at RT for overnight. The resulting mixture was concentrated under vacuum to get 5-bromo-l-[2-fluoro-6-(trifluoromethyl) benzyl]-6- methyl-3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-pyrimidine-2,4-(lH,3H)-dione which was crystallised in methanol: water (175 ml: 50 ml) to get pure compound of Formula II (27.5g, 70% yield).
	With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran;	To 5-BROMO-1-[2-FLUORO-6-(TRIFLUOROMETHYL) benzyl] -6-methylpyrimidine- 2,4 (1FI, 3H)-DIONE LD (15 g, 39.4 mmol) in 225 mL of THF were added N-T-BOC-D- phenylglycinol (11.7 g, 49.2 mmol) and triphenylphosphine (15.5 g, 59.1 mmol), followed by addition of di-tert-butyl azodicarboxylate (13.6 g, 59.1 mmol). The resulting yellow solution was stirred overnight. The volatiles were evaporated and the residue was purified by silica gel with 3: 7 EtOAc/Hexane to give le as a white solid (23.6 g, 39.4 mmol). MS (CI) m/z 500.0 (MH+-Boc).

	With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran;	To 5-BROMO-1- [2-FLUORO-6- (TRIFLUOROMETHYL) BENZYL]-6-METHYLPYRIMIDINE- 2,4 (1H, 3H)-DIONE LD (15 g, 39.4 mmol) in 225 mL of THF were added N-T-BOC-D- phenylglycinol (11.7 g, 49.2 mmol) and triphenylphosphine (15.5 g, 59.1 mmol), followed by addition of di-tert-butyl azodicarboxylate (13.6 g, 59.1 mmol). The resulting yellow solution was stirred overnight. The volatiles were evaporated and the residue was purified by silica gel with 3: 7 EtOAc/Hexane to give le as a white solid (23.6 g, 39.4 mmol). MS (CI) M/Z 500.0 (MH+-Boc).
	With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 5 - 25℃; for 2.2h;	29.95 g of intermediate N-6, 26.86 g of D-BOC-phenylglycinol, 30.92 g of triphenylphosphine and 299 mL of tetrahydrofuran are loaded in that order into a round- bottom flask. It is cooled to 5 C and a solution of di-tert-butyl azodicarboxylate (27.19 g) dissolved in 150 mL of tetrahydrofuran is dripped in about 40 minutes. The system is brought to 25 C and kept in agitation for 1.5 hours. (0088) At the end of the reaction (HPLC control) the solvent is removed by distillation at reduced pressure at 45 C. The residue is added with 377 mL of isopropyl acetate and kept in agitation at 5-10 C for 1 hour. The suspension is filtered by washing the solid with 20 mL of isopropyl acetate. (0089) The liquid phase obtained by filtration is concentrated at reduced pressure at 45 C until a yellow oil is obtained that is reacted as such in the subsequent reaction. (0090) The compound N-6, used as a starting reactant of the method, has the appearance of a white solid; its purity, determined with HPLC, is 99%. 1H-NMK (400MHz, DMSO-d6): 511.91 (s, 1H); 7.66 (d, 1H, J = 7.6 Hz); 7.59-7.51 (m, 2H); 5.34 (s, 2H); 2.46 (s, 3H); (0091) A sample of the intermediate N-5 obtained in the test of the example, purified exclusively for analytical purposes, is analysed and identified through 1H-NMR and mass spectroscopy. 1H-NMK (400MHZ, DMSO-d6): 7.66 (d, 1H, J = 7.6 Hz); 7.61-7.48 (m, 2H); 7.36-7,21 (m, 5H); 5.35 (dd, 2H, J = 22,0/17.0 Hz); 4.93-4.88 (m, 1H); 4.10-3.99 (m, 2H); 2.53 (s, 3H); 1.35 (s, 9H).

Reference： [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 7478 - 7485
[2]Patent: CN111333587,2020,A .Location in patent: Paragraph 0138; 0143; 0156-0159
[3]Patent: WO2020/194115,2020,A1 .Location in patent: Page/Page column 25
[4]Patent: WO2005/7164,2005,A1 .Location in patent: Page 27
[5]Patent: WO2005/7165,2005,A1 .Location in patent: Page 28
[6]Patent: WO2021/44230,2021,A1 .Location in patent: Page/Page column 12

2
[ 830346-49-1 ]
[ 352303-67-4 ]
[ 830346-51-5 ]

Yield	Reaction Conditions	Operation in experiment
83%	With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 90℃;	To 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2 (R) - tert-butoxycarbonylamino-2-phenylethyl] -pyrimidine-2, 4 (1H, 3H)-dione le (15 g, 25 mmol) in 30 mL/90 mL of H2O/DIOXANE in a pressure tube were added 2-fluoro-3- methoxyphenylboronic acid (4.25 g, 25 mmol) and sodium carbonate (15.75 g, 150 mmol). N2 gas was bubbled through for 10 min. Tetrakis (triphenylphosphine) palladium (2.9 g, 2.5 mmol) was added, the tube was sealed and the resulting mixture was heated at 90 C overnight. After cooling to ambient temperature, the precipitate was removed by filtration. The volatiles were removed by evaporation and the residue was partitioned between EtOAc/sat. NAHC03. The organic solvent was evaporated and the residue was chromatographed with 2: 3 EtOAc/Hexane to give 13.4 g (20.8 mmol, 83 %) yellow solid. This yellow solid (6.9 g, 10.7 mmol) was dissolved in 20 ML/20 mL CH2C12/TFA. The resulting yellow solution was stirred at room temperature for 2 hours. The volatiles were evaporated and the residue was partitioned between EtOAc/ sat. NAHC03. The organic phase was dried over NA2S04. Evaporation gave lf as a yellow oil (4.3 g, 7.9 mmol, 74%). 1H NMR (CDC13) 8 2.031 (s, 3H), 3.724-4. 586 (m, 6H), 5.32-5. 609 (m, 2H), 6.736-7. 558 (m, 11H) ; MS (CI) M/Z 546.0 (MH+). 3- [2 (R)-AMINO-2-PHENYLETHYL]-5- (2-FLUORO-3-METHOXYPHENYL)-L- [2, 6- DIFLUOROBENZYL]-6-METHYL-PYRIMIDINE-2, 4 (1H, 3I)-DIONE LF. L was made using the same procedure described in this example.
83%	With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 90℃;	To 5-bromo-l- [2-fluoro-6- (trifluoromethyl) benzyl]-6-methyl-3- [2 (R) - tert-butoxycarbonylamino-2-phenylethyl] -pyrimidine-2, 4 (1H, 3H )-DIONE LE (15 g, 25 mmol) in 30 mL/90 mL of H2O/dioxane in a pressure tube were added 2-fluoro-3- methoxyphenylboronic acid (4.25 g, 25 mmol) and sodium carbonate (15.75 g, 150 mmol). N2 gas was bubbled through for 10 min. Tetrakis (triphenylphosphine) palladium (2.9 g, 2.5 mmol) was added, the tube was sealed and the resulting mixture was heated with stirring at 90 C overnight. After cooling to ambient temperature, the precipitate was removed by filtration. The volatiles were removed by evaporation and the residue was partitioned between EtOAc/sat. NAHC03. The organic solvent was evaporated and the residue was chromatographed with 2: 3 EtOAc/Hexane to give 13.4 g (20.8 mmol, 83 %) yellow solid. This yellow solid (6.9 g, 10.7 mmol) was dissolved in 20 mL/20 mL CH2C12/TFA. The resulting yellow solution was stirred at room temperature for 2 hours. The volatiles were evaporated and the residue was partitioned between EtOAc/ sat. NAHC03. The organic phase was dried over NA2S04. Evaporation gave If as a yellow oil (4.3 g, 7.9 mmol, 74%). 'H NMR (CDC13) 8 2.03 (s, 3H), 3.72-4. 59 (m, 6H), 5.32-5. 61 (m, 2H), 6.74-7. 56 (M, 11H) ; MS (CI) M/Z 546.0 (MH+).
83%		To 5-BROMO-1- [2-FLUORO-6- (TRIFLUOROMETHYL) BENZYL]-6-METHYL-3- [2 (R) - TERT-BUTOXYCARBONYLAMINO-2-PHENYLETHYL]-PYRIMIDINE-2, 4 (1H, 3H)-DIONE 4e (15 g, 25 mmol) in 30 mL/90 mL of H2O/DIOXANE in a pressure tube were added 2-fluoro-3- methoxyphenylboronic acid (4.25 g, 25 mmol) and sodium carbonate (15.75 g, 150 mmol). N2 gas was bubbled through for 10 min. Tetrakis (triphenylphosphine) palladium (2.9 g, 2. 5 mmol) was added, the tube was sealed and the resulting mixture was heated at 90 oC overnight. After cooling to ambient temperature, the precipitate was removed by filtration. The volatiles were removed by evaporation and the residue was partitioned between EtOAc/sat. NAHC03. The organic solvent was evaporated and the residue was chromatographed with 2: 3 EtOAc/Hexane to give 13.4 g (20.8 mmol, 83 %) yellow solid

67%	With palladium diacetate; potassium carbonate; XPhos; In toluene; at 110℃; for 16h;Inert atmosphere;	The (R)-tert-butyl (2-(5-bromo-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2, 3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate (5.1g, 16.7mmol),(2-Fluoro-3-methoxy-phenyl)boronic acid (4.25g, 25.0mmol), potassium carbonate (6.98g, 50.0mmol),2-Dicyclohexylphosphorus-2',4',6'-triisopropylbiphenyl (810mg, 1.67mmol), palladium acetate (190mg, 0.83mmol) andToluene (160mL) was added to a 250mL single-necked round bottom flask, and reacted at 110C for 16 hours under nitrogen protection;The reaction was stopped, after cooling to room temperature, filtered, and the filtrate was spin-dried under reduced pressure.Separation and purification by column chromatography (petroleum ether/ethyl acetate (v/v)=4/1) gave the title compound as a white solid (7.25 g, 67%).
	With potassium phosphate; (2?dicyclohexylphosphino?2?,4?,6??triisopropyl?1,1??biphenyl)[2?(2??methylamino?1,1??biphenyl)]palladium(II) methanesulfonate; In 1,4-dioxane; water; at 70℃; for 3.5h;	6 g of tert-butyl (R)-(2-(5-bromo-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo- 3,6-dihydropyrimidin-l(2H)-yl)-l-phenylethyl)carbamate and 2.2 g of 2-fluoro-3- methoxyphenyl)boronic acid were dissolved in 80 ml of dioxane. To the mixture a solution of 6.36 g of potassium phosphate tribasic in 20 ml of water was added. Obtained clear solution was degassed for 10 min at room temperature. Then, 8.6 mg of Pd-Xphos-G4 was added. The solution was stirred at 70 C for 3.5 hours. Reaction mixture was cooled down to approx 45 C and approx 50 ml of the solvent was removed by evaporation. The residue was diluted with 70 ml of ethyl acetate and 70 ml of saturated aqueous solution of NaHCCfi. The phases were separated and the aqueous phase was extracted once more with 70 ml of ethyl acetate. The combined organic extracts were dried over MgS04, filtered and concentrated to provide 5.9 g (91% of theoretical yield) of compound (7) (purity 91% HPLC IN).

Reference： [1]Patent: WO2005/7164,2005,A1 .Location in patent: Page 27-28
[2]Journal of Medicinal Chemistry,2008,vol. 51,p. 7478 - 7485
[3]Patent: WO2005/7165,2005,A1 .Location in patent: Page 28-29
[4]Patent: WO2005/7633,2005,A1 .Location in patent: Page 39-40
[5]Patent: CN111333587,2020,A .Location in patent: Paragraph 0138; 0143; 0160-0162
[6]Patent: WO2019/115019,2019,A1 .Location in patent: Page/Page column 23-24

3
[ 476493-27-3 ]
[ 830346-49-1 ]
[ 1308380-86-0 ]

Yield	Reaction Conditions	Operation in experiment
33%	In acetonitrile at 120℃; for 3h; Microwave irradiation;	22.A Step A. {(R)-2-[5-(4-benzyl-3-hydroxymethyl-piperazin-1-yl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester (1-Benzyl-piperazin-2-yl)-methanol (200 mg, 0.97 mmol), {(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester (50 mg, 0.083 mmol), and acetonitrile (1 mL) were placed in a microwave vessel and stirred at 120° C. for 3 hrs with microwave irradiation. After concentration of the solution, the residue was purified using silica gel chromatography (eluent: hexane/ethyl acetate/dichloromethane, 1/1/1) and dried in a vacuum to afford 20 mg of a colorless oil (yield 33%) . 1H NMR (300 MHz, CDCl3) δ 1.37 (9H, s), 2.23 (1H, m), 2.34 (3H, s), 2.41-2.66 (2H, m), 2.85 (1H, m), 3.16 (1H, m), 3.49 (1H, m), 3.72 (1H, m), 3.93-4.15 (3H, m), 4.21 (1H, m), 5.03 (1H, m), 5.42 (2H, dd), 5.74 (1H, m), 7.21 (2H, m), 7.18-7.26 (10H, m), 7.54 (1H, d)
	In acetonitrile at 120℃; for 3h; microwave irradiation;	22.A (1-Benzyl-piperazin-2-yl)-methanol (200 mg, 0.97 mmol), {(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethylbenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester (50 mg, 0.083 mmol), and acetonitrile (1 mL) were placed in a microwave vessel and stirred at 120°C for 3 hrs with microwave irradiation. After concentration of the solution, the residue was purified using silica gel chromatography(eluent: hexane/ethyl acetate/dichloromethane, 1/1/1) and dried in a vacuum to afford 20 mg of a colorless oil (yield 330) [Show Image] 1H NMR (300MHz, CDCl3) δ 1.37(9H, s), 2.23(1H, m), 2.34(3H, s), 2.41-2.66(2H, m), 2.85(1H, m), 3.16(1H, m), 3.49(1H, m), 3.72(1H, m), 3.93-4.15(3H, m), 4.21(1H, m), 5.03(1H, m), 5.42(2H, dd), 5.74(1H, m), 7.21(2H, m), 7.18- 7.26(10H, m), 7.54(1H, d)

Reference： [1]Current Patent Assignee: TIUMBIO - US2013/137661, 2013, A1 Location in patent: Paragraph 0191
[2]Current Patent Assignee: TIUMBIO - EP2390250, 2011, A2 Location in patent: Page/Page column 82

4
[ 830346-49-1 ]
[ 352303-67-4 ]
[ 830346-51-5 ]
2,2'-difluoro-3,3'-dimethoxy-1,1'-biphenyl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide; In acetone; for 5h;Inert atmosphere; Reflux;	12 g of compound VI and 9.53 g of <strong>[352303-67-4]2-fluoro-3-methoxybenzeneboronic acid</strong> were added to the reaction flask.4.48g sodium hydroxide, 3.24g tetrakistriphenylphosphine palladium and 200mL acetone, nitrogen protection,Heat to reflux, after 5 hours, Add 3.32 g of acetic acid and continue to reflux for 1 hour. The mixture was cooled to room temperature, filtered, and the filtrate was concentrated under reduced pressure. 0.34 g of a white solid was obtained.Its structural identification data is as follows:

Reference： [1]Patent: CN109293634,2019,A .Location in patent: Paragraph 0035; 0036

5
[ 830346-47-9 ]
[ 830346-49-1 ]

Reference： [1]Patent: WO2019/115019,2019,A1

6
[ 830346-46-8 ]
[ 830346-49-1 ]

Reference： [1]Patent: CN111333587,2020,A

7
[ 830346-48-0 ]
[ 102089-75-8 ]
[ 830346-49-1 ]

Yield	Reaction Conditions	Operation in experiment
90 g	With tetrabutylammomium bromide; potassium carbonate; In water; toluene; at 25 - 60℃; for 4h;	Toluene (600 ml), water (300.0 ml) were added to 5-bromo-1-(2-fluoro-6- (trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione (100 gms) at 25-30C. Potassium carbonate (92 gms), tetrabutylammonium bromide (42 gms) and the compound of example-4 were added to the above reaction mixture at 25-30C. Heated the reaction mixture to 55-60C and stirred for 4 hrs at same temperature. Separated the organic layer and washed the organic layer with water. Distilled off the solvent from the organic layer. Dissolved the obtained crude in ethyl acetate and added to pre-cooled n-heptane, stirred for about 2 hrs. Filtered the precipitated solid and added to ethyl acetate and methanol followed by heating the reaction mixture to 55-60C and stirred for about 1 hr at same temperature. Cooled the reaction mixture to 25-30C and stirred for about 1 hr at same temperature. Filtered the obtained solid, washed with the mixture of ethylene glycol and methanol followed by water and then dried to get the title compound. (0088) (Yield: 90 gms, purity: 99.29% by HPLC, Impurity-la: 0.28%, Impurity-2a: 0.20%, Impurity- 3a: Not detected).

Reference： [1]Patent: WO2021/130776,2021,A1 .Location in patent: Page/Page column 18

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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 830346-49-1 ] {[proInfo.proName]}

Quality Control of [ 830346-49-1 ]

Related Doc. of [ 830346-49-1 ]

Product Details of [ 830346-49-1 ]

Safety of [ 830346-49-1 ]

Application In Synthesis of [ 830346-49-1 ]

[ 830346-49-1 ] Synthesis Path-Downstream 1~7

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry