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Chemical Structure| 848695-25-0 Chemical Structure| 848695-25-0

Structure of BIIB021
CAS No.: 848695-25-0

Chemical Structure| 848695-25-0

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BIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.

Synonyms: CNF2024

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Product Details of BIIB021

CAS No. :848695-25-0
Formula : C14H15ClN6O
M.W : 318.76
SMILES Code : COC1=C(C)C(CN2C=NC3=C2N=C(N)N=C3Cl)=NC=C1C
Synonyms :
CNF2024
MDL No. :MFCD15528939
InChI Key :QULDDKSCVCJTPV-UHFFFAOYSA-N
Pubchem ID :16736529

Safety of BIIB021

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of BIIB021

DNA

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Molt-4 cells 50–800 mM 48 and 72 hours BIIB021 dose-dependently inhibited the growth of Molt-4 cells and induced G0/G1 phase arrest and apoptosis. PMC4002565

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00412412 Breast Cancer Phase 1 Completed - United States, Florida ... More >> Research Site Tampa, Florida, United States, 33612 United States, New York Research Site New York, New York, United States, 10021 United States, Texas Research site Houston, Texas, United States, 77030 Less <<
NCT00345189 Tumors|Lymphoma PHASE1 COMPLETED 2025-04-09 Research site, Scottsdale, Ari... More >>zona, 85258, United States|Research site, New Haven, Connecticut, 06520, United States|Research site, San Antonio, Texas, 78245, United States|Research site, Sutton, Surrey, SM2 5PT, United Kingdom Less <<
NCT00344786 B-Cell Chronic Lymphocytic Leu... More >>kemia Less << Phase 1 Terminated(Sponsor's decision) - United States, California ... More >> Research Site San Diego, California, United States, 92093 United States, New York Research site New York, New York, United States, 10021 United States, Texas Research site Houston, Texas, United States, 77030 Less <<
NCT00618735 Advanced Solid Tumors Phase 1 Completed - United States, California ... More >> Research Site Encinitas, California, United States, 92024 Research Site Santa Monica, California, United States, 90404 United States, Texas Research Site San Antonio, Texas, United States, 78229 Less <<
NCT01004081 Breast Cancer Phase 2 Completed - -
NCT01017198 Advanced Solid Tumors Phase 1 Completed - United States, Arizona ... More >> Reseach Facility Scottsdale, Arizona, United States United States, California Reseach Facility Encinitas, California, United States United States, Texas Reseach Facility San Antonio, Texas, United States Less <<
NCT00618319 GIST PHASE2 COMPLETED 2025-04-10 Reseach Facility, Encinitas, C... More >>alifornia, United States|Research Site, Santa Monica, California, 90404, United States|Reseach Facility, San Antonio, Texas, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.69mL

3.14mL

1.57mL

31.37mL

6.27mL

3.14mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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