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[ CAS No. 855531-22-5 ] {[proInfo.proName]}

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Chemical Structure| 855531-22-5
Chemical Structure| 855531-22-5
Structure of 855531-22-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 855531-22-5 ]

CAS No. :855531-22-5 MDL No. :MFCD11986872
Formula : C11H7F3N2O3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :304.25 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 855531-22-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 855531-22-5 ]

[ 855531-22-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1113-59-3 ]
  • [ 142229-74-1 ]
  • [ 855531-22-5 ]
YieldReaction ConditionsOperation in experiment
53% In ethanol at 60℃; for 1h; 1.S A mixture of 12.9 g (54.6 mmol) [4- (trifluoromethoxy) phenyl]-thiourea, and 9.3 g (55.7 mmol) bromopyruvic acid in 70 ml ethanol was heated to 60 °C for 1 h. The precipitate was filtered off and washed with small portions of cold ethanol to yield after drying 8.9 g (53 %) of the title compound as crystalline solid. MS (m/e): 303.1 (M-H)
  • 2
  • [ 855531-22-5 ]
  • [ 21900-54-9 ]
  • 2-[(2-chloro-4-fluorobenzoyl)-(4-trifluoromethoxyphenyl)amino]-thiazole-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In tetrahydrofuran at 50℃; for 48h; 1.U A mixture of 2.0 g (6.6 mmol) 2- (4- (trifluoromethoxy) phenylamino) -thiazole-4- carboxylic acid, 3.17 g (16.4 mmol) 2-chloro-4-fluorobenzoyl chloride and 0.92 g (6.6 mmol) potassium carbonate in 50 mL THF was stirred at 50°C for 48 h. After evaporation of the volatiles the residue was partitioned between water and ethyl acetate. Organic phases were pooled, dried with MgS04 and the solvent was removed in vacuo. Crystallisation from n-heptane/ethyl acetate yielded 3.4 g of the title compound which was used without further purification. MS (m/e): 459.0, 461.0 (M-H)
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