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[ CAS No. 856851-48-4 ]

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2D
Chemical Structure| 856851-48-4
Chemical Structure| 856851-48-4
Structure of 856851-48-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 856851-48-4 ]

Related Doc. of [ 856851-48-4 ]

SDS

Product Details of [ 856851-48-4 ]

CAS No. :856851-48-4MDL No. :MFCD09835252
Formula : C7H8ClNO Boiling Point : 230.9±20.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :157.60Pubchem ID :23437036
Synonyms :

Computed Properties of [ 856851-48-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 856851-48-4 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 856851-48-4 ]

  • Upstream synthesis route of [ 856851-48-4 ]
  • Downstream synthetic route of [ 856851-48-4 ]

[ 856851-48-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 41288-96-4 ]
  • [ 75-03-6 ]
  • [ 856851-48-4 ]
YieldReaction ConditionsOperation in experiment
90% With potassium carbonate In N,N-dimethyl-formamide at 0 - 40℃; for 2.00 h; To a stirred solution of 6-chloropyridin-3-ol (3.0 g, 23.2 mmol) in N,N-dimethylformamide (30 mL) was added iodoethane (4.33 g, 27.8 mmol, 2.22 mL), and potassium carbonate (9.60 g, 69.6 mmol) at 0°C. The reaction was warmed and stirred at 40 00 for 2 h. The reaction mixture was quenched by addition of water (30 mL) then the mixture was extracted with ethyl acetate (60 mL x 3). The combined organicphases were washed with saturated aqueous sodium chloride solution (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give 2-chloro-5-ethoxypyridine (3.30 g, 20.9 mmol, 90 percent) as a yellow solid. 1H NMR (400 MHz, ODd3) O 7.97(d, J2.9 Hz, 1H), 7.17- 7.07(m, 2H), 3.99 (q, J7.0 Hz, 2H), 1 .36 (t, J7.0 Hz, 3H).
Reference: [1] Patent: WO2018/81167, 2018, A1. Location in patent: Page/Page column 231; 232; 241
Historical Records

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