[ CAS No. 85711-13-3 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 85711-13-3
Chemical Structure| 85711-13-3
Structure of 85711-13-3

Quality Control of [ 85711-13-3 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 85711-13-3 ]

SDS

Product Details of [ 85711-13-3 ]

CAS No. :85711-13-3MDL No. :MFCD04112588
Formula :C8H17NOBoiling Point :273.8°C at 760 mmHg
Linear Structure Formula :C8H17ONInChI Key :-
M.W :143.23Pubchem ID :-
Synonyms :

Computed Properties of [ 85711-13-3 ]

TPSA : 46.2 H-Bond Acceptor Count : 2
XLogP3 : 1 H-Bond Donor Count : 2
SP3 : 1.00 Rotatable Bond Count : 2

Safety of [ 85711-13-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P305+P351+P338UN#:N/A
Hazard Statements:H302-H319Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 85711-13-3 ]

  • Upstream synthesis route of [ 85711-13-3 ]
  • Downstream synthetic route of [ 85711-13-3 ]

[ 85711-13-3 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 14328-52-0 ]
  • [ 85711-13-3 ]
YieldReaction ConditionsOperation in experiment
400 mg With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 80℃; for 4.00 h; Step 1: To a stirred mixture of LiAlH4 (724 mg, 19.08 mmol) in anhydrous THF (20 mL) at rt was addedportionwise 2-cyclohexyl-D-glycine (1 g, 6.36 mmol). The mixture was heated at 80 °C for 4 h. The mixture was cooled to 0 °C and then water (1 mL), 1M aq NaOH (1 mL), and water (3 mL) were added sequentially. The mixture was filteredand the filtrate was partitioned between a mixture of DCM, 1M aq NaOH, and saturated aq sodium potassium tartrate.The organic layer was separated and further washed with 1M aq NaOH. The organic was separated, dried over MgSO4filtered, and concentrated under reduced pressure to afford (R)-2-amino-2-cyclohexylethanol (400 mg) which was notpurified further. LCMS (ESI) m/z 144 (M+H)+.
Reference: [1] Chemische Berichte, 1986, vol. 119, # 7, p. 2191 - 2207
[2] Journal of Organic Chemistry, 1983, vol. 48, # 13, p. 2195 - 2202
[3] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0536
  • 2
  • [ 875-74-1 ]
  • [ 85711-13-3 ]
Reference: [1] Chemische Berichte, 1986, vol. 119, # 7, p. 2191 - 2207
[2] Journal of Organic Chemistry, 1983, vol. 48, # 13, p. 2195 - 2202
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