Alternatived Products of [ 863870-88-6 ]
Product Details of [ 863870-88-6 ]
| CAS No. : | 863870-88-6 |
MDL No. : | MFCD08166322 |
| Formula : |
C6H4BrIO
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | QJLSNAHXGXLMLR-UHFFFAOYSA-N |
| M.W : | 298.90 g/mol |
Pubchem ID : | 11415311 |
| Synonyms : |
|
Safety of [ 863870-88-6 ]
Application In Synthesis of [ 863870-88-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 863870-88-6 ]
- 1
-
[ 74128-84-0 ]
-
[ 863870-88-6 ]
| Yield | Reaction Conditions | Operation in experiment |
| 86% |
With boron tribromide; In dichloromethane; at 0 - 20℃; for 2h; |
<strong>[74128-84-0]2-bromo-1-iodo-3-methoxybenzene</strong> (0.88 g, 2.81 mmol) obtained in Step B was dissolved in DCM (4 mL) andcooled to 0-5C. 1M BBr3 (8.4 mL, 8.43 mmol) was slowly added dropwise thereto, and the mixture was stirred at 0-5Cfor 1 hour and additionally stirred at room temperature for 1 hour. After termination of the reaction, the reaction solutionwas cooled to -20C and diluted by slowly adding methanol. The mixture was stirred at room temperature for 30 minutes.After addition of saturated NaHCO3 aqueous solution, the reaction solution was extracted with DCM. The organic layerwas dried with anhydrous magnesiumsulfate, concentrated under reduced pressure and purified by column chromatography(eluent, EtOAc/Hex = 1/5) to obtain the title compound (0.723 g, 86%).1H NMR (500 MHz, CDCl3) delta 7.43-7.39(m, 1H), 7.02-6.92 (m, 2H), 5.61 (s, 1H) |
- 2
-
[ 863870-88-6 ]
-
[ 74-88-4 ]
-
[ 74128-84-0 ]
| Yield | Reaction Conditions | Operation in experiment |
| 88% |
With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 14.5h; |
An oven-dried 10 mL round bottom flask which was equipped with a magnetic stir bar and fitted with a septum and argon filled balloon was charged with 2-bromo-3-iodophenol (150 mg, 0.5 mmol) and anhydrous DMF (0.3 mL). To the reaction mixture, K2CO3 (173 mg, 1.25 mmol) was added and the reaction mixture was stirred at room temperature for 30 min before adding MeI (0.16 mL, 2.5 mmol). The reaction mixture was allowed to stir at room temperature for 14 h and water (10 mL) was added. The mixture was extracted with diethyl ether (3×20 mL) and the combined organic extracts were washed with brine, dried over Na2SO4, filtered and the solvent was removed with the aid of a rotary evaporator. The crude material was purified by flash chromatography (silica gel, 2:98 EtOAc:hexanes) to afford an off-white colored solid (0.138 g, 88% yield). 1H NMR (600 MHz, CDCl3) delta 7.48-7.46 (m, 1H), 6.99 (t, 3JH,H=8.1 Hz, 1H), 6.85-6.83 (m, 1H), 3.86 (s, 3H) ppm. |
- 3
-
[ 863870-88-6 ]
-
[ 7462-74-0 ]
-
[ 1287791-72-3 ]
- 4
-
[ 863870-88-6 ]
-
[ 86-58-8 ]
-
2-bromo-3-(quinolin-8-yl)phenol
[ No CAS ]
- 5
-
[ 101935-40-4 ]
-
[ 863870-88-6 ]
- 6
-
[ 100367-36-0 ]
-
[ 863870-88-6 ]
- 7
-
[ 67853-37-6 ]
-
[ 863870-88-6 ]
- 8
-
[ 112970-44-2 ]
-
[ 863870-88-6 ]
- 9
-
[ 863870-88-6 ]
-
halomethane
[ No CAS ]
-
[ 74128-84-0 ]
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
Life Science
For Research Only
100K+ Compounds
Competitive Price
1-2 Day Shipping
