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[ CAS No. 864776-02-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 864776-02-3
Chemical Structure| 864776-02-3
Structure of 864776-02-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 864776-02-3 ]

CAS No. :864776-02-3 MDL No. :MFCD09879905
Formula : C11H17BO3 Boiling Point : -
Linear Structure Formula :- InChI Key :JMLBPHNESOKSEV-UHFFFAOYSA-N
M.W : 208.06 Pubchem ID :24229547
Synonyms :

Safety of [ 864776-02-3 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 864776-02-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 864776-02-3 ]

[ 864776-02-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 26452-80-2 ]
  • [ 864776-02-3 ]
  • [ 1374310-54-9 ]
YieldReaction ConditionsOperation in experiment
52.5% With sodium carbonate In 1,4-dioxane; water at 85℃; for 4h; Inert atmosphere; Intermediate 31 : 2-Chloro-4-(2-methyl-3-furanyl)pyrimidine2,4-Dichloropyrimidine (1 .0 g, 6.71 mmol), 4,4,5,5-tetramethyl-2-(2-methyl-3-furanyl)- 1 ,3,2-dioxaborolane (1 .397 g, 6.71 mmol), sodium carbonate (1 .067 g, 10.07 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.388 g, 0.336 mmol) were added together in 1 ,4-dioxane (42 mL) and water (7.00 mL) and the resulting mixture was heated at 85 eC under argon for 4 hours. The reaction mixture was allowed to cool to room temperature, diluted with water and extracted with ethyl acetate (x 3). The ethyl acetate layers were combined, dried over magnesium sulfate and evaporated under reduced pressure. The residue was purified by Biotage SP4 column chromatography eluting with a gradient of 0- 30 % ethyl acetate and iso-hexane. Product containing fractions were combined and evaporated under reduced pressure to give the title compound (686 mg, 3.52 mmol, 52.5 % yield) as a white solid. LC/MS [M+H]+ = 195/197
  • 2
  • [ 864776-02-3 ]
  • [ 1005-37-4 ]
  • 4-N-methyl-6-(2-methylfuran-3-yl)pyrimidine-2,4-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; at 80 - 100℃; General procedure: General procedure 17: A mixture of the corresponding 6-chloro-4-N-(alkyl)- pyrimidine-2,4-diamine compound (1.0 equiv.), the appropriate arylboronic ester (1.5 equiv.), Pd(OAc)2 (0.10 equiv.), SPhos (0.20 equiv), and K3P03 (3.0 equiv.) was stirred in a suitable solvent (ethanol or a 5:2 mixture of 1-butanol and water) at 80 - 100 C until LCMS indicated full conversion. The crude mixture was then diluted with NaHC03 (aq) and extracted with DCM *3. The crude material was purified by preparative LC or by silica gel chromatography.
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