Alternatived Products of [ 877402-82-9 ]
Product Details of [ 877402-82-9 ]
| CAS No. : | 877402-82-9 |
MDL No. : | MFCD09835000 |
| Formula : |
C7H4F3N3O
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | PLEQTMITFTVUCP-UHFFFAOYSA-N |
| M.W : |
203.12
|
Pubchem ID : | 68519389 |
| Synonyms : |
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Safety of [ 877402-82-9 ]
Application In Synthesis of [ 877402-82-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 877402-82-9 ]
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[ 877402-82-9 ]
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[ 877402-79-4 ]
| Yield | Reaction Conditions | Operation in experiment |
| 81% |
With N,N-dimethyl-formamide; trichlorophosphate for 12h; Reflux; |
Preparation of 4-chloropyrazolo[1,5-a]pyrazines 1a-d (General method).
General procedure: DMF (3 drops) was added to a suspension of compound 7a-d (4 mmol) in POCl3 (10 ml) and refluxed for 10 h (compound 1a), 12 h (compounds 1b,d), or 15 h (compound 1c). The excess of POCl3 was removed by distillation at reduced pressure, the residue was mixed with ice (10 g) and Na2CO3 (1 g), the mixture was then extracted with CH2Cl2 (3×10 ml). The organic layer was separated, dried over anhydrous Na2SO4, evaporated, and the residue was recrystallized from a mixture hexane-benzene, 3:1. Products 1a-d were isolated as yellow powders. |
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With DEA; trichlorophosphate for 15h; Heating / reflux; |
39.C
A mixture of 60 mg (0.295 mmol) of 2-(trifluoromethyl)pyrazolo[l,5-a]pyrazin-4(5/f)-one, 0.149 mL (140 mg, 0.94 mmol) of W,./V-diethylaniline, and 3 mL of phosphorus oxychloride wasstirred at reflux for 15 h. The cooled solution was partitioned between ethyl acetate and 2N aqueoushydrochloric acid. The organic phase was washed with an additional portion of 2N aqueous hydrochloricacid and then with saturated sodium carbonate aqueous solution. The ethyl acetate solution was driedover sodium sulfate, filtered, and concentrated. Purification of the residue by flash chromatography onsilica gel (5-20% ethyl acetate in hexanes) afforded the title compound as a pale yellow solid.LC-MS 222 (M+l). |
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With <i>N</i>,<i>N</i>-dimethyl-aniline; trichlorophosphate In toluene for 0.25h; Reflux; |
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Reference：
[1]Hrynyshyn, Yevhenii V.; Tsizorik, Nazar M.; Musiychuk, Anna R.; Bol’but, Andriy V.; Vovk, Mykhailo V.
[Chemistry of Heterocyclic Compounds, 2017, vol. 53, # 11, p. 1242 - 1247][Khim. Geterotsikl. Soedin., 2017, vol. 53, # 11, p. 1242 - 1247,6]
[2]Current Patent Assignee: MERCK & CO INC - WO2006/23750, 2006, A2
Location in patent: Page/Page column 63
[3]Liu, Meihuan; Su, Hui; Cheng, Weiren; Yu, Feifan; Li, Yuanli; Zhou, Wanlin; Zhang, Hui; Sun, Xuan; Zhang, Xiuxiu; Wei, Shiqiang; Liu, Qinghua
[Small, 2022, vol. 18, # 27]
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[ 129768-28-1 ]
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[ 877402-82-9 ]
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