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Chemical Structure| 877874-85-6 Chemical Structure| 877874-85-6

Structure of KG5
CAS No.: 877874-85-6

Chemical Structure| 877874-85-6

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KG5 is an orally active dual conformational inhibitor of PDGFRβ and B-Raf with anti-cancer and anti-angiogenic effects. It also inhibits Flt3, KIT, and c-Raf, suitable for research in various cancers treatment, especially in angiogenesis-related tumors.

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Product Details of KG5

CAS No. :877874-85-6
Formula : C20H16F3N7OS
M.W : 459.45
SMILES Code : FC(F)(F)C=1C=CC=C(C1)NC2=NN=C(N2)C=3C=CC(OC4=NC(=NC(N)=C4)SC)=CC3
MDL No. :MFCD27665470

Safety of KG5

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of KG5

RTK
MAPK

Isoform Comparison

Biological Activity

Description
KG5 is an orally active dual inhibitor of PDGFRβ and B-Raf through allosteric mechanisms. Additionally, KG5 exhibits inhibitory activity against Flt3, KIT, and c-Raf. The compound possesses anticancer and antiangiogenic properties [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.88mL

2.18mL

1.09mL

21.77mL

4.35mL

2.18mL

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