* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
To a stirred solution of the crude 4-(2-methylimidazol-1-yl)benzaldehyde (1.0 g) in methanol(15 ml) cooled to 0° C. was added NaBH4 (0.2 g, 5.2 mmol) in portions over 15 min and the whole stirred for 1 h. A saturated aqueous NH4 Cl solution (50 ml) was added to the reaction mixture and the whole extracted with ethyl acetate (100 ml*2). The organic layer was washed with water (100 ml), brine (50 ml), dried over MgSO4, and solvent removed under reduced pressure. The crude product was washed with an Et2 O/ethyl acetate mixture (3:1, 15 ml) to give the title compound (0.51 g, 50 percent) as a white powder. 1 H NMR (CDCl3) δ: 7.5 (d, 2H, J=8 Hz), 7.28 (d, 2H, J=8 Hz), 7.01 (d, 1H, J=1 Hz), 6.99 (d, 1H, J=1 Hz), 4.78 (s, 2H), 2.35 (s, 3H).
Reference：
[1] Patent: US5753682, 1998, A,
2
[ 693-98-1 ]
[ 459-57-4 ]
[ 88427-96-7 ]
Reference：
[1] Patent: US5753682, 1998, A,
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1107 - 1111
With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
Working Example 34 4-(6-Chloronaphthanlene-2-sulfonyl)-1-[4-(2-methyl-1H-imidazol-1-yl)benzyl]-2-piperazinone To a solution of N-(tert-butoxycarbonyl)ethylenediamine (431 mg) and <strong>[88427-96-7]4-(2-methyl-1H-imidazol-1-yl)benzaldehyde</strong> (500 mg) in dichloromethane (10 ml) was added acetic acid (323 mg), and the mixture was stirred at room temperature for 1 hour. To the mixture was added, under ice-cooling, sodium triacetoxyborohydride (855 mg), and the mixture was stirred at room temperature for 15 hours. The reaction solution was concentrated, and the residue was dissolved in ethyl acetate. The solution was extracted with water, and the aqueous layer was made alkaline with sodium hydroxide solution. The mixture was extracted with dichloromethane and dried with sodium sulfate, and sodium sulfate was filtered off. To the filtrate was added triethylamine (543 mg) and then was added at 0 C. chloroacetyl chloride (455 mg), and the mixture was stirred at room temperature for 30 minutes. The reaction solution was washed with sodium bicarbonate solution and brine, dried and concentrated, and the residue was dissolved in DMF (15 ml). To the solution was added sodium hydride in oil (129 mg), and the mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated, and the residue was dissolved in ethyl acetate. The solution was washed with water and brine, dried and concentrated, and the residue was purified with column chromatography (ethyl acetate) to give 4-(tert-butoxycarbonyl)-1-[4-(2-methyl-1H-imidazol-1-yl)benzyl]-2-piperazinone.
To a stirred solution of the crude 4-(2-methylimidazol-1-yl)benzaldehyde (1.0 g) in methanol(15 ml) cooled to 0 C. was added NaBH4 (0.2 g, 5.2 mmol) in portions over 15 min and the whole stirred for 1 h. A saturated aqueous NH4 Cl solution (50 ml) was added to the reaction mixture and the whole extracted with ethyl acetate (100 ml*2). The organic layer was washed with water (100 ml), brine (50 ml), dried over MgSO4, and solvent removed under reduced pressure. The crude product was washed with an Et2 O/ethyl acetate mixture (3:1, 15 ml) to give the title compound (0.51 g, 50 %) as a white powder. 1 H NMR (CDCl3) delta: 7.5 (d, 2H, J=8 Hz), 7.28 (d, 2H, J=8 Hz), 7.01 (d, 1H, J=1 Hz), 6.99 (d, 1H, J=1 Hz), 4.78 (s, 2H), 2.35 (s, 3H).
a. 4(2-Methylimidazol-1-yl)benzyl alcohol To a suspension of NaH (0.612 g, 15.3 mmol: 60% suspension of mineral oil) of in dry DMF (10 ml) cooled to 10 C. was added a DMF (8 ml) solution of 2-methylimidazole (1.23 g, 15 mmol) under a nitrogen atmosphere, and the mixture was stirred for 30 min at room temperature. 4-Fluorobenzaldehyde (1.90 g, 15.3 mmol) was added to the reaction mixture, and the resulting solution was stirred for 14 h. The reaction mixture was poured into an ice-cold saturated aqueous NH4 Cl solution (100 ml) and extracted with ethyl acetate (100 ml*2). The organic layer was washed with water (100 ml) and brine (80 ml), dried over MgSO4 and the solvent removed under reduced pressure. The resultant residue was purified by column chromatography (SiO2; hexane:ethyl acetate=1:1 then ethyl acetate) to give crude 4-(2-methylimidazol-1-yl)-benzaldehyde (1.0 g), which was used without further purification.
2-methyl-1[4-(2-nitro-1-propenyl)-phenyl]-imidazole[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
(a) 2-methyl-1[4-(2-nitro-1-propenyl)-phenyl]-imidazole Similar to example 4(a), the reaction is carried out with 66 g <strong>[88427-96-7]4-(2-methyl-1-imidazolyl)-benzaldehyde</strong> (DE-OS No. 33 06 196), 31.7 g nitroethane, 3.2 g beta-alanine and 250 ml n-butanol. Yield: 30 g. melting point 164-166 C. IR (in KBr): 1605, 15,06, 1323 cm-1. MS [m/e]: 243 (M+, 100%), 196 (16%), 169 (14%), 154 (12%), 129 (21%), 128 (20%), 115 (33%).
4-[4-(2-Methyl-1-imidazolyl)phenyl]-3-methyl-4-oxobutyronitrile[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
In N-methyl-acetamide; water;
(a) 4-[4-(2-Methyl-1-imidazolyl)phenyl]-3-methyl-4-oxobutyronitrile To a mixture of 33.6 g of <strong>[88427-96-7]4-(2-methyl-1-imidazolyl)benzaldehyde</strong> and 400 ml of dimethylformamide under a nitrogen atmosphere was added 0.78 g of sodium cyanide and then with stirring at 30 C. 10.7 g of 2-butenenitrile was added dropwise. The reaction mixture was stirred at 25 C. under nitrogen for another 16 hours. Following the addition of one liter of water the mixture was extracted with chloroform, and the chloroform phase was washed with water, dried over sodium sulfate, and concentrated. The residue was purified by column chromatography (silica gel/chloroform) and then reprecipitated with chloroform/hexane. Yield: 30.5 g (75% of theoretical) Mp 97-98 C. IR (in KBr): 2242, 1680 cm-1 MS [m/e]: 253 (M+, 42%), 185 (100%), 157 (27%), 116 (18%).
A mixture of malonitrile (110 mg, 1.66 mmol) and 4-(2-methyl-1H-imidazol-1- yl)benzaldehyde (309 mg, 1.66 mmol) in 8 mL of anhydrous ethanol was charged with N- methylmorpholine (0.18 mL, 1.66 mmol) for 10 min. To the mixture was added 1,3-dimethyl- 1H-pyrazol-5(4H)-one (186 mg, 1.66 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The suspension was filtered under vacuum and a pink solid was obtained. The solid was gently washed with hexanes (20 mL) and chilled ethanol (10 mL) and further dried under high vacuum to provide compound 16 as a bright yellow powder (260 mg, 44%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 7.74 (d, J = 8.4 Hz, 2H), 7.67 (d, J = 8.4 Hz, 2H), 7.63 (s, 1H), 7.49 (brs, 2H), 7.24 (s, 1H), 5.05 (s, 1H), 3.96 (s, 3H), 2.61 (s, 3H), 2.07 (s, 3H). MS (ESI): Calcd for C19H18N6O: 346, found: 347 (M+H)+.
3-(benzofuran-2-yl)-1-methyl-1H-pyrazol-5(4H)-one[ No CAS ]
[ 109-77-3 ]
C26H20N6O2[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
45%
A mixture of malonitrile (109 mg, 1.65 mmol) and 4-(2-methyl-1H-imidazol-1- yl)benzaldehyde (309 mg, 1.65 mmol) in 8 mL of anhydrous ethanol was charged with N- methylmorpholine (0.18 mL, 1.65 mmol) for 10 min. To the mixture was added 3- (benzofuran-2-yl)-1-methyl-1H-pyrazol-5(4H)-one (353 mg, 1.65 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The reaction mixture was concentrated on rotavapor to dryness and the resulting crude product was purified by Teledyne-Isco flash system by using CH2Cl2/MeOH, 0 to 7% of methanol in dichloromethane to provide compound 40 as a viscous brownish solid (100 mg, 45%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 7.59-7.54 (m, 3H), 7.44 (s, 1H), 7.30 (d, J = 8.4 Hz, 2H), 7.16 (d, J = 8.2 Hz, 2H), 6.98-6.92 (m, 4H), 5.22 (s, 1H), 4.25 (s, 1H), 2.93 (s, 3H), 2.28 (s, 3H). MS (ESI): Calcd for C26H20N6O2: 448, found: 449 (M+H)+.
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